Kornblith, Aaron E Singh, Chandan Devlin, Gabriel Addo, Newton Streck, Christian J Holmes, James F Kuppermann, Nathan Grupp-Phelan, Jacqueline Fineman, Jeffrey Butte, Atul J
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Objective The Pediatric Emergency Care Applied Research Network (PECARN) has developed a clinical-decision instrument (CDI) to identify children at very low risk of intra-abdominal injury. However, the CDI has not been externally validated. We sought to vet the PECARN CDI with the Predictability Computability Stability (PCS) data science framework,...
Pagano, Livio Salmanton-García, Jon Marchesi, Francesco Blennow, Ola Gomes da Silva, Maria Glenthøj, Andreas van Doesum, Jaap Bilgin, Yavuz M López-García, Alberto Itri, Federico
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Limited data are available on breakthrough COVID-19 in patients with hematologic malignancy (HM) after anti-severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccination. Adult patients with HM, ≥1 dose of anti-SARS-CoV-2 vaccine, and breakthrough COVID-19 between January 2021 and March 2022 were analyzed. A total of 1548 cases were incl...
Bender Ignacio, Rachel A Wohl, David A Arends, Rosalin Pilla Reddy, Venkatesh Mu, Ying Javan, Arzhang Cyrus Hughes, Michael D Eron, Joseph J Currier, Judith S Smith, Davey
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AZD7442 (Evusheld) is a combination of two human anti-severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) monoclonal antibodies (mAbs), tixagevimab (AZD8895) and cilgavimab (AZD1061). Route of administration is an important consideration to improve treatment access. We assessed pharmacokinetics (PKs) of AZD7442 absorption following 600 mg ...
Santos, Lucianna H Kronenberger, Thales Almeida, Renata G Silva, Elany B Rocha, Rafael EO Oliveira, Joyce C Barreto, Luiza V Skinner, Danielle Fajtová, Pavla Giardini, Miriam A
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The worldwide COVID-19 pandemic caused by the coronavirus SARS-CoV-2 urgently demands novel direct antiviral treatments. The main protease (Mpro) and papain-like protease (PLpro) are attractive drug targets among coronaviruses due to their essential role in processing the polyproteins translated from the viral RNA. In this study, we virtually scree...
Koenig, Kristi L Beÿ, Christian K Marty, Aileen M
Monkeypox 2022, a zoonotic virus similar to smallpox, presented as a rapidly escalating human outbreak with community transmission outside endemic regions of Africa. In just over one month of detection, confirmed cases escalated to over 3300, with reports of patients in at least 43 non-African nations. Mechanisms of transmission in animals and the ...
Shmeleva, Evgeniya V Syafiq, Danial Moldoveanu, Ana L Ferguson, Brian J Smith, Geoffrey L
Vaccinia virus (VACV) protein N1 is an intracellular immunomodulator that contributes to virus virulence via inhibition of NF-κB. Intradermal infection with a VACV lacking gene N1L (vΔN1) results in smaller skin lesions than infection with wild-type virus (WT VACV), but the impact of N1 deletion on the local microbiota as well as the innate and cel...
Vogelsang, Eric M Polonijo, Andrea N
BackgroundAlthough more than half of older adults receive the annual influenza vaccine (flu shot), only about one-third have ever been vaccinated for shingles. With this in mind, our study examines how the associations between sociodemographic characteristics, health behaviors, and vaccine uptake differ between these two viruses. In doing so, it al...
Hettle, David Hutchings, Stephanie Muir, Peter Moran, Ed (cog-uk) consortium, uk covid-19 genomic...
BACKGROUND: Most patients with SARS-CoV-2 are non-infectious within 2 weeks, though viral RNA may remain detectable for weeks. However there are reports of persistent SARS-CoV-2 infection, with viable virus and ongoing infectivity months after initial detection. Beyond individuals, viral evolution during persistent infections may be accelerated, dr...
Choudhary, Manish C Chew, Kara W Deo, Rinki Flynn, James P Regan, James Crain, Charles R Moser, Carlee Hughes, Michael D Ritz, Justin Ribeiro, Ruy M
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SARS-CoV-2 mutations that cause resistance to monoclonal antibody (mAb) therapy have been reported. However, it remains unclear whether in vivo emergence of SARS-CoV-2 resistance mutations alters viral replication dynamics or therapeutic efficacy in the immune-competent population. As part of the ACTIV-2/A5401 randomized clinical trial (NCT04518410...
Chiang, En-Pei Isabel Syu, Jia-Ning Hung, Hung-Chang Rodriguez, Raymond L Wang, Wei-Jan Chiang, En-Rung Chiu, Shao-Chih Chao, Che-Yi Tang, Feng-Yao
Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2) is a novel coronavirus that infects many types of cells and causes cytokine storms, excessive inflammation, acute respiratory distress to induce failure of respiratory system and other critical organs. In this study, our results showed that trimethylamine-N-oxide (TMAO), a metabolite gener...