The Ewing Sarcoma breakpoint region 1 protein (EWSR1) is a member of the FET (FUS, EWSR1, and TAF15) family of proteins, implicated in several aspects of cell biology and found mutated in multiple diseases. Primarily, EWSR1 attracted broad attention as one of the most susceptible genes to breakage/translocation, originally identified because of the...
Natural variation in living organisms is essential in stress responses and adaptation to new environments. Many of the traits presenting natural variation are regulated by a complex genetic architecture of genes with small to moderate effects. Consequently, understanding which variants impact traits of medical, industrial or agronomical interest is...
peer reviewed / BackgroundAsthma is characterized by morphological modifications of the airways (inflammation and remodelling) and bronchial hyperresponsiveness. Mechanisms linking these two key features of asthma are still poorly understood. ADAM28 (a disintegrin and metalloproteinase 28) might play a role in asthma pathophysiology. ADAM28 exists ...
Evaluating the risks and benefits of using traditional medicinal plants is of utmost importance for a huge fraction of the human population, particularly in Northern Vietnam, which is home to one of the largest repertoires of tropical biota, both in terms of plants and of microorganisms. Ten to fifteen plants were selected based on their traditiona...
The rhizosphere is the narrow zone where interactions between plant roots, soil and a myriad of microorganisms affect nutrients biogeochemical cycling (including phosphorus (P)) and crop productivity. Given the dependency of today’s agriculture and food production on external P inputs, exploring the ability of roots and their microbial symbionts to...
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peer reviewed / Solid tumors consist of tumor cells associated with stromal and immune cells, secreted factors and extracellular matrix (ECM), that together constitute the tumor microenvironment. Among stromal cells, activated fibroblasts, known as cancer-associated fibroblasts (CAFs) are of particular interest. CAFs secrete a plethora of ECM compo...
peer reviewed / Distinctive structural, chemical, and physical properties make the diarylmethane scaffold an essential constituent of many active biomolecules nowadays used in pharmaceutical, agrochemical, and material sciences. In this work, 33 novel diarylmethane molecules aiming to target colorectal cancer were designed. Two series of functional...
peer reviewed / The rising concerns about controversial food additives’ potential hazardous properties require extensive yet animal-minimized testing strategies. Zebrafish embryos are the ideal in vivo model representing both human and environmental health. In this study, we exposed zebrafish embryos to eight controversial food additives. Our resul...
The management of light energy during photosynthesis requires the concerted participation of multiple cellular processes, being the regulation of light absorption and the electron transfer in the photosynthetic machinery in the frontline. Due to the high diversity and divergence of microalgae groups, different molecular components can be found in t...
