Genera, Mariano Quioc-Salomon, Barbara Nourisson, Antonin Colcombet-Cazenave, Baptiste Haouz, Ahmed Mechaly, Ariel Matondo, Mariette Duchateau, Magalie König, Alexander Windisch, Marc P.
...
Published in
Scientific Reports
Interactions between the hepatitis B virus core protein (HBc) and host cell proteins are poorly understood, although they may be essential for the propagation of the virus and its pathogenicity. HBc has a C-terminal PDZ (PSD-95, Dlg1, ZO-1)-binding motif (PBM) that is responsible for interactions with host PDZ domain-containing proteins. In this wo...
Abbasi, Bilal Haider Khan, Taimoor Khurshid, Razia Nadeem, Muhammad Drouet, Samantha Hano, Christophe
Published in
Scientific Reports
Fagonia indica (L.) is an important medicinal plant with multitude of therapeutic potentials. Such application has been attributed to the presence of various pharmacological important phytochemicals. However, the inadequate biosynthesis of such metabolites in intact plants has hampered scalable production. Thus, herein, we have established an in vi...
Zhang, Yingyi Dijkman, Patricia M. Zou, Rongfeng Zandl-Lang, Martina Sanchez, Ricardo M. Eckhardt-Strelau, Luise Köfeler, Harald Vogel, Horst Yuan, Shuguang Kudryashev, Mikhail
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Published in
Nature Communications
Pentameric ligand-gated ion channels (pLGICs) are key players in neurotransmission and have been shown to be modulated by the lipid environment, however the underlying mechanism is not well understood. Here, the authors report structures of the pLGIC 5-HT3A serotonin receptor reconstituted into lipid bilayer discs and reveal lipid–protein interacti...
Rocha, Thais Bastos da Cruz Paulino, Ruan Soares, Diego Moraes Policarpo, Wendel Adelino da Silva Filho, Ednaldo Monteiro, Maria Vivina Barros de Macedo, Michelly Fernandes de Moraes Pereira, Helder
Published in
Tropical Animal Health and Production
This research aimed to obtain a hematological and biochemical profile of buffalos (Bubalus bubalis) bred in a region of the Brazilian Legal Amazon. A total of 73 animals of mixed races, divided into three groups, were studied: group 1 (G1) comprised animals up to 11 months old; in group 2 (G2), subjects were 12 to 23 months old; and, in group 3 (G3...
Cabiles, Ma. Monica Lira, Brandon Cyril Janairo, Jose Isagani; De La Salle Unive...
Biomineralization is a bio-inspired technique of creating inorganic nanostructures using peptides or proteins. An important consideration in selecting a biomineralization agent is the overall shape or geometry of the protein since this can influence the properties of the produced nanostructures. The green fluorescent protein (GFP) from the jellyfis...
Villa, Luca Gazzonis, Alessia Libera Zanzani, Sergio Aurelio Mazzola, Silvia Giordano, Alessia Manfredi, Maria Teresa
Published in
Parasites & Vectors
BackgroundBesnoitia besnoiti is an Apicomplexan protozoa causative of bovine besnoitiosis, a chronic and debilitating disease of cattle, with a variety of pathological findings that could alter some laboratory parameters. A study was conducted in a bovine besnoitiosis endemically infected dairy herd located in Italy characterized by high intra-herd...
Rodrigo, Miguel Angel Merlos Michalkova, Hana Strmiska, Vladislav Casar, Berta Crespo, Piero de los Rios, Vivian Ignacio Casal, J. Haddad, Yazan Guran, Roman Eckschlager, Tomas
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Published in
Scientific Reports
Metallothionein-3 has poorly characterized functions in neuroblastoma. Cisplatin-based chemotherapy is a major regimen to treat neuroblastoma, but its clinical efficacy is limited by chemoresistance. We investigated the impact of human metallothionein-3 (hMT3) up-regulation in neuroblastoma cells and the mechanisms underlying the cisplatin-resistan...
Groveman, Bradley R. Ferreira, Natalia C. Foliaki, Simote T. Walters, Ryan O. Winkler, Clayton W. Race, Brent Hughson, Andrew G. Zanusso, Gianluigi Haigh, Cathryn L.
Published in
Scientific Reports
Creutzfeldt–Jakob Disease (CJD) is a fatal, currently incurable, neurodegenerative disease. The search for candidate treatments would be greatly facilitated by the availability of human cell-based models of prion disease. Recently, an induced pluripotent stem cell derived human cerebral organoid model was shown to take up and propagate human CJD pr...
Sheng, Jie Gadella, Bart M. Olrichs, Nick K. Kaloyanova, Dora V. Helms, J. Bernd
Published in
Scientific Reports
Cysteine-rich secretory proteins (CRISPs) are a subgroup of the CRISP, antigen 5 and PR-1 (CAP) superfamily that is characterized by the presence of a conserved CAP domain. Two conserved histidines in the CAP domain are proposed to function as a Zn2+-binding site with unknown function. Human CRISP1 is, however, one of the few family members that la...
Guo, Hanze Chi, Yan Chi, Naiyu
Published in
Scientific Reports
Inflammatory bowel disease (IBD) is a chronic, recurrent inflammatory disease of the gastrointestinal (GI) tract. Ulcerative colitis (UC) is a type of IBD. Pregnane X Receptor (PXR) is a member of the nuclear receptor superfamily. In order to deepen understanding and exploration of the molecular mechanism of regulation roles of PXR on UC, biologica...
