Abbasi, Bilal Haider Khan, Taimoor Khurshid, Razia Nadeem, Muhammad Drouet, Samantha Hano, Christophe
Published in
Scientific Reports
Fagonia indica (L.) is an important medicinal plant with multitude of therapeutic potentials. Such application has been attributed to the presence of various pharmacological important phytochemicals. However, the inadequate biosynthesis of such metabolites in intact plants has hampered scalable production. Thus, herein, we have established an in vi...
Shushan, Avital Kosloff, Mickey
Published in
Scientific Reports
The interactions of the antibiotic proteins colicins/pyocins with immunity proteins is a seminal model system for studying protein–protein interactions and specificity. Yet, a precise and quantitative determination of which structural elements and residues determine their binding affinity and specificity is still lacking. Here, we used comparative ...
Wigner, Paulina Zielinski, Krzysztof Michlewska, Sylwia Danielska, Paulina Marczak, Agnieszka Ricci, Eduardo Junior Santos-Oliveira, Ralph Szwed, Marzena
Published in
Scientific Reports
Even though application of nanoparticles in medicine seems to provide unique solutions for drug delivery and diagnosis diseases, understanding interactions between nanoscale materials and biological systems is imperative. Therefore, this study determined the effect of different types of nanoparticles (NPs) on human endothelial cells and examined th...
Milo, Scarlet Heylen, Rachel A. Glancy, John Williams, George T. Patenall, Bethany L. Hathaway, Hollie J. Thet, Naing T. Allinson, Sarah L. Laabei, Maisem Jenkins, A. Toby A.
...
Published in
Scientific Reports
Infection and blockage of indwelling urinary catheters is significant owing to its high incidence rate and severe medical consequences. Bacterial enzymes are employed as targets for small molecular intervention in human bacterial infections. Urease is a metalloenzyme known to play a crucial role in the pathogenesis and virulence of catheter-associa...
Saccò, Mattia Blyth, Alison J. Humphreys, William F. Cooper, Steven J. B. White, Nicole E. Campbell, Matthew Mousavi-Derazmahalleh, Mahsa Hua, Quan Mazumder, Debashish Smith, Colin
...
Published in
Scientific Reports
Groundwaters host vital resources playing a key role in the near future. Subterranean fauna and microbes are crucial in regulating organic cycles in environments characterized by low energy and scarce carbon availability. However, our knowledge about the functioning of groundwater ecosystems is limited, despite being increasingly exposed to anthrop...
Gonzalez, Abner Mannen, Taro Çağatay, Tolga Fujiwara, Ayano Matsumura, Hiroyoshi Niesman, Ashley B. Brautigam, Chad A. Chook, Yuh Min Yoshizawa, Takuya
Published in
Scientific Reports
Mutations in the RNA-binding protein FUS cause familial amyotropic lateral sclerosis (ALS). Several mutations that affect the proline-tyrosine nuclear localization signal (PY-NLS) of FUS cause severe juvenile ALS. FUS also undergoes liquid–liquid phase separation (LLPS) to accumulate in stress granules when cells are stressed. In unstressed cells, ...
Yeliseev, Alexei Iyer, Malliga R. Joseph, Thomas T. Coffey, Nathan J. Cinar, Resat Zoubak, Lioudmila Kunos, George Gawrisch, Klaus
Published in
Scientific Reports
Signaling through integral membrane G protein-coupled receptors (GPCRs) is influenced by lipid composition of cell membranes. By using novel high affinity ligands of human cannabinoid receptor CB2, we demonstrate that cholesterol increases basal activation levels of the receptor and alters the pharmacological categorization of these ligands. Our re...
Karami, Sajedeh Doroodmand, Mohammad Mahdi Taherianfar, Mahnaz Mutabi-Alavi, Amir Nagshgar, Nahid
Published in
Scientific Reports
Probable mechanism behind the neuronal ephaptic coupling is investigated based on the introduction of “Brain”-triggered potential excitation signal smartly with a specific very low frequency ( VLF ) waves as a neuronal motor toolkit. Detection of this electric motor toolkit is attributed to in-vitro precise analyses of a neural network of snail, al...
Gaudreault, Jimmy Liberelle, Benoît Durocher, Yves Henry, Olivier De Crescenzo, Gregory
Published in
Scientific Reports
Surface plasmon resonance-based biosensors have been extensively applied to the characterization of the binding kinetics between purified (bio)molecules, thanks to robust data analysis techniques. However, data analysis for solutions containing multiple interactants is still at its infancy. We here present two algorithms for (1) the reliable and ac...
Chen, Mei Wu, Dongming Tu, Shihua Yang, Chaoyin Chen, DeJie Xu, Ying
Published in
Scientific Reports
Long non-coding RNAs (lncRNAs) have been proposed as diagnostic biomarkers for the screening of non-small cell lung cancer and monitoring disease progression. Accordingly, new, rapid, and cost-effective lncRNA biosensors that can be used clinically are urgently needed. Herein, a novel effective and ultrasensitive electrochemical biosensor was devel...
