Pony, Pauline Rapisarda, Chiara Terradot, Laurent Marza, Esther Fronzes, Rémi
Published in
Nature Communications
Acetaldehyde–alcohol dehydrogenase (AdhE) converts acetyl-CoA to ethanol and is a key enzyme in bacterial alcoholic fermentation. AdhE forms spirosomes and, here, the authors present the cryoEM structures of compact and extended E.coli AdhE spirosomes and show that the extended conformation is the catalytically active form of the enzyme and discuss...
Jafari Eshlaghi, Mohammadreza D'Haese, Arnout Zlopasa, J. Cornelissen, Emile Vrouwenvelder, J.S. Verbeken, Kim Verliefde, Arne van Loosdrecht, M.C.M. Picioreanu, C.
Cobos, Marianela Pérez, Sheyla Braga, Janeth Vargas-Arana, Gabriel Flores, Leenin Paredes, Jae D. Maddox, J. Dylan Marapara, Jorge L. Castro, Juan C.
Published in
World Journal of Microbiology and Biotechnology
A plausible strategy to mitigate socioeconomic problems in the Peruvian Amazon is through the sustainable exploitation of biodiversity resources, such as native microalgae. Several studies worldwide affirm that these microorganisms are excellent sources of higher value products for human nutrition and possess health-promoting biochemicals, but thes...
Rusere, Linah Lockbaum, Gordon J. Henes, Mina Lee, Sook-Kyung Spielvogel, Ean Rao, Desaboini Nageswara Kosovrasti, Klajdi Nalivaika, Ellen A. Swanstrom, Ronald Yilmaz, Nese Kurt
...
The design, synthesis, and X-ray structural analysis of hybrid HIV-1 protease inhibitors (PIs) containing bis-tetrahydrofuran (bis-THF) in a pseudo-C2-symmetric dipeptide isostere are described. A series of PIs were synthesized by incorporating bis-THF of darunavir on either side of the Phe-Phe isostere of lopinavir in combination with hydrophobic ...
Padilla-Benavides, Teresita Reyes-Gutierrez, Pablo Imbalzano, Anthony N.
Myogenesis is the biological process by which skeletal muscle tissue forms. Regulation of myogenesis involves a variety of conventional, epigenetic, and epigenomic mechanisms that control chromatin remodeling, DNA methylation, histone modification, and activation of transcription factors. Chromatin remodeling enzymes utilize ATP hydrolysis to alter...
panić, marko jakovetić, dušan vukobratović, dejan crnojević, vladimir pižurica, aleksandra
Reconstruction of magnetic resonance images (MRI) benefits from incorporating a priori knowledge about statistical dependencies among the representation coefficients. Recent results demonstrate that modeling intraband dependencies with Markov Random Field (MRF) models enable superior reconstructions compared to inter-scale models. In this paper, we...
Ejazi, Sarfaraz Ahmad Ghosh, Smriti Bhattacharyya, Anirban Kamran, Mohd Das, Sonali Bhowmick, Sudipta Rahaman, Mehebubar Goswami, Rama Prosad Ali, Nahid
Published in
Parasites & Vectors
BackgroundVisceral leishmaniasis (VL), is a parasitic disease that causes serious medical consequences if treatment is delayed. Despite a decline in the number of VL cases in the Indian subcontinent, the commencement of the disease in newer areas continues to be a major concern. Although serological diagnosis mainly by immunochromatographic tests h...
pieters, olivier de swaef, tom lootens, peter stock, michiel roldán-ruiz, isabel wyffels, francis
The study of the dynamic responses of plants to short-term environmental changes is becoming increasingly important in basic plant science, phenotyping, breeding, crop management, and modelling. These short-term variations are crucial in plant adaptation to new environments and, consequently, in plant fitness and productivity. Scalable, versatile, ...
Eisenstein, Michael
Published in
Nature
Computational approaches help to map the extensive biochemical chatter between bacteria and their human hosts.
lefever, gerlinde snoeck, didier de belie, nele van vlierberghe, sandra van hemelrijck, danny aggelis, dimitrios g.
To mitigate autogenous shrinkage in cementitious materials and simultaneously preserve the material&rsquo / s mechanical performance, superabsorbent polymers and nanosilica are included in the mixture design. The use of the specific additives influences both the hydration process and the hardened microstructure, while autogenous healing of cracks c...
