Silva, Diogo Sousa, Ana Catarina Robalo, M Paula Martins, Lígia O
Published in
New biotechnology
Lignin is the second most abundant natural polymer next to cellulose and by far the largest renewable source of aromatic compounds on the planet. Dye-decolourising peroxidases (DyPs) are biocatalysts with immense potential in lignocellulose biorefineries to valorize emerging lignin building blocks for environmentally friendly chemicals and material...
Hasan, Nurain Shahera Ling, Jonathan Guyang Bakar, Mohd Faizal Abu Seman, Wan Mohd Khairulikhsan Wan Murad, Abdul Munir Abdul Bakar, Farah Diba Abu Khalid, Rozida Mohd
Published in
Applied biochemistry and biotechnology
Enzymatic halogenation captures scientific interest considering its feasibility in modifying compounds for chemical diversity. Currently, majority of flavin-dependent halogenases (F-Hals) were reported from bacterial origin, and as far as we know, none from lichenized fungi. Fungi are well-known producers of halogenated compounds, so using availabl...
Gardner, Eric D Johnson, Bryce P Dimas, Dustin A McClurg, Heather E Severance, Zachary C Burgett, Anthony W Singh, Shanteri
Published in
ChemCatChem
Aza-substitution, the replacement of aromatic CH groups with nitrogen atoms, is an established medicinal chemistry strategy for increasing solubility, but current methods of accessing functionalized azaindoles are limited. In this work, indole-alkylating aromatic prenyltransferases (PTs) were explored as a strategy to directly functionalize azaindo...
Eom, Tokla Isanapong, Jantiya Kumnorkaew, Pisist Songthanasak, Krisanavej Pornwongthong, Peerapong
Published in
E3S Web of Conferences
The consumption of fossil fuels to fulfill the global energy demand can cause global warming issues. Renewable energy, i.e., bioethanol, from lignocellulosic biomass, is a promising source of alternative energy to fossil fuels. The conversion of lignocellulosic biomass into bioethanol requires the release of fermentable sugars during the saccharifi...
Ju, Shuyun Kuzelka, Kaylee Guo, Rui Krohn-Hansen, Benjamin Wu, Jianping Nair, Satish Yang, Yang
Catalytic asymmetric α-alkylation of carbonyl compounds represents a long-standing challenge in synthetic organic chemistry. Herein, we advance a dual biocatalytic platform for the efficient asymmetric alkylation of α-keto acids. First, guided by our recently obtained crystal structures, we develop SgvMVAV as a general biocatalyst for the enantiose...
Zhang, Yong Chu, Jia-Min
Published in
Chembiochem : a European journal of chemical biology
Engineered heme proteins were developed to possess numerous excellent biocatalytic nitrenoid C-H functionalizations. Computational approaches such as density functional theory (DFT), hybrid quantum mechanics/molecular mechanics (QM/MM), and molecular dynamics (MD) calculations were employed to help understand some important mechanistic aspects of t...
spalletta;, alexis
Surfactants are amphiphilic molecules with the ability to modify the surface tension between two surfaces. They can be obtained by various methods, the main one being synthetic, from petroleum-based substrates. Their universal use in a wide range of fields has created a global market and, consequently, ecological, and economic expectations for thei...
Sursin, Emmanuel Flourat, Amandine Akissi, Z. Martinez, Agathe Borie, Nicolas Peyrot, Cedric Courot, Eric Nuzillard, Jean-Marc Renault, Jean-Hugues Voutquenne-Nazabadioko, Laurence
...
Resveratrol dimers are of great interest for pharmaceutical and cosmetic applications. Nevertheless, the yield of their bioproduction is limited by both the competition between the possible radical–radical coupling pathways and complex isolation procedures. Alternative organic synthesis methods do not afford higher yields. Although enzymatic routes...
Reyre, Jean-Lou Grisel, Sacha Haon, Mireille Xiang, Ruite Gaillard, Jean-Charles Armengaud, Jean Guallar, Victor Margeot, Antoine Arragain, Simon Berrin, Jean-Guy
...
Lytic polysaccharide monooxygenases (LPMOs) are taxonomically widespread copper-enzymes boosting biopolymers conversion (e.g. cellulose, chitin) in Nature. White-rot Polyporales, which are major fungal wood decayers, may possess up to 60 LPMO-encoding genes belonging to the auxiliary activities family 9 (AA9). Yet, the functional relevance of such ...
Cascelli, Nicoletta Lettera, Vincenzo Sannia, Giovanni Gotor-Fernández, Vicente Lavandera, Iván
Published in
ChemSusChem
Laccases are oxidative enzymes with high synthetic potential. In this work, their value in biocatalysis is shown through the green and selective oxidation of furfuryl alcohol into furfural with the aid of mediators. The influence of different parameters, such as pH, enzyme/mediator composition, buffer type, cosolvent tolerance, and reaction times, ...
