Huang, Chunlei Wang, Helin Shi, Xinyan Wang, Yanhong Li, Ping Yin, Hanqin Shao, Yixian
Published in
Ecotoxicology (London, England)
Selenium (Se) is an essential element for human health. Se-enriched agricultural products can promote people's intake of Se. Microorganisms play an important role in Se cycling. In this study, two new bacterial strains were isolated from paddy soil and were identified as Chitinophaga sp. and Comamonas testosteroni, respectively. More than 44% and 3...
Remanan, Mejo Kuzhithariel Zhu, Fan
Published in
Food chemistry
Rutin is a polyphenol with excellent therapeutic potential and good safety profile, but the poor bioavailability restricts its application as a functional ingredient. However, this limitation may be mitigated by encapsulation. In this study, promising prospects of starch nanoparticles (SNPs) produced via ultra-sonication for rutin encapsulation was...
Evang, Esther Charlotte Habte, Tsige-Yohannes Owino, Willis Omondi Krawinkel, Michael Bernhardt
Published in
European journal of nutrition
In the rural Kenyan diet, the bioavailability of iron is low and predisposes the population to iron deficiency. Fruit pulp of the indigenous baobab tree contains significant amounts of vitamin C, which enhances non-heme iron bioavailability. We studied the impact of baobab fruit pulp (BFP) consumption on the hemoglobin (Hb) and iron status of Kenya...
Schilling, Kathrin Basu, Anirban Kaplan, Alicia Perkins, William T
Published in
Environmental geochemistry and health
Soils in the Lower Swansea Valley, (United Kingdom) contain elevated level of metals, enough to cause direct or indirect effects on human health. This study assesses the severity of soil pollution and bioavailability of Cu and other metals (Ni, Zn, Co, Pb and Cr) in soils with various distances from a Ni refinery. We compare Cu concentrations in op...
Sinha, Shweta Prakash, Ajay Medhi, Bikash Sehgal, Alka Batovska, Daniela I. Sehgal, Rakesh
Published in
BMC Research Notes
ObjectiveMalaria is a major global health concern with the urgent need for new treatment alternatives due to the alarming increase of drug-resistant Plasmodium strains. Chalcones and its derivatives are important pharmacophores showing antimalarial activity. Determination of the pharmacokinetic variables at the preliminary step of drug development ...
Tung, Nguyen-Thach Tran, Cao-Son Nguyen, Tran-Linh Pham, Thi-Minh-Hue Chi, Sang-Cheol Nguyen, Hoang-Anh Bui, Quang-Dong Bui, Duc-Nhat Tran, Thi-Quyen
Published in
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences
This study aimed to investigate the effect of a surfactant on the liquid-liquid phase separation, dissolution, diffusion, and the oral bioavailability of a weakly basic drug (l-tetrahydropalmatine; l-THP) from an amorphous solid dispersion (ASD). The carrier used in the ASD was optimized by the application of casting film, solvent shift, and pH shi...
Shaaban, Nashwa A. Shreadah, Mohamed A. El-Rayis, Osman A. Hamdan, Amira M.
Published in
Environmental Monitoring and Assessment
Sediments from Lake Mariut, Egypt, after its rehabilitation, and its anoxic diverted polluted drains were subjected to five sequential steps to define different geochemical fractions of eight studied metals. Results cleared out that 30–50% of its total Cd and total Co contents are easily bioavailable with a high-risk assessment code (RAC) to enter ...
Eesam, Shivarani Bhandaru, Jaswanth S. Akkinepally, Raghuram Rao Bobbala, Ravi Kumar
Published in
Future Journal of Pharmaceutical Sciences
BackgroundCocrystallization is one of the crystal engineering strategies used to alter the physicochemical properties of drugs that are poorly water-soluble. Gliclazide (GLZ), an antidiabetic drug, belongs to Biopharmaceutical Classification System class-II (low solubility and high permeability) and has low bioavailability, resulting in poor therap...
Pancholi, Vaibhavi Smina, Thozhuthum Parambil Kunnumakkara, Ajaikumar B. Maliakel, Balu Krishnakumar, Illathu Madhavamenon
Published in
Toxicology Reports
Recently, there is a growing concern about the use of curcumin supplements owing to a few reported hepatotoxicity related adverse events among some of the long-term consumers. Even though no clear evidence was elucidated for the suspected toxicity, the addition of adjuvants that inhibits body’s essential detoxification pathways, adulteration with s...
Yang, Xue Lin, Kun Tan, Lijun Wang, Jiangtao
Published in
Marine pollution bulletin
A mesocosm experiment was conducted on the Qingdao coast to study the effects of nutrient enrichment on the physiological responses of Ulva prolifera and the changes in the entire culture system during decomposition of algal blooms. The decomposition trend of U. prolifera off the Qingdao coast was slightly retarded by nutrient enrichment, and could...
