Zhou, Enchen Hoeke, Geerte Li, Zhuang Eibergen, Arthur C Schonk, Amber W Koehorst, Martijn Boverhof, Renze Havinga, Rick Kuipers, Folkert Coskun, Tamer
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Published in
Cardiovascular research
Brown fat activation accelerates the uptake of cholesterol-enriched remnants by the liver and thereby lowers plasma cholesterol, consequently protecting against atherosclerosis development. Hepatic cholesterol is then converted into bile acids (BAs) that are secreted into the intestine and largely maintained within the enterohepatic circulation. We...
Jia, Ya-Qian Yuan, Zi-Wen Zhang, Xiao-Song Dong, Jia-Qi Liu, Xue-Nan Peng, Xiao-Ting Yao, Wan-Ling Ji, Peng Wei, Yan-Ming Hua, Yong-Li
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Published in
Journal of ethnopharmacology
Sophora alopecuroides L is one of the most commonly used plants in traditional medicine for the management conditions including inflammatory and gastrointestinal disease. However, the therapeutic mechanism of Sophora alopecuroides L.particularly in inflammatory bowel disease (IBD) remains unclear. To evaluate the treatment effects of total alkaloid...
Shi, Wei Jiang, Yan Zhao, Dong-Sheng Jiang, Li-Long Liu, Feng-Jie Wu, Zi-Tian Li, Zhuo-Qing Wang, Ling-Li Zhou, Jing Li, Ping
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Published in
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
Studies have shown that 8-epidiosbulbin E acetate (EEA), a major diterpenoid lactone in the tuber of Dioscorea bulbifera, can induce hepatotoxicity in vivo. However, the underlying mechanisms remain unknown. Using the integrated transcriptomic and metabolomics method, in this study we investigated the global effect of EEA exposure on the transcript...
Chen, Qichao Liu, Min Zhang, Pengyu Fan, Shujun Huang, Jinli Yu, Shunying Zhang, Caihua Li, Huajun
Published in
Nutrition (Burbank, Los Angeles County, Calif.)
Dyslipidemia is an important risk factor for cardiovascular diseases. Fucoidan (FUC) is a polysaccharide extracted from brown marine algae with various biological activities. Galactooligosaccharides (GOS) are important prebiotics that exert benefits on the intestinal microbiota. The aim of this study was to investigate the effects of FUC and GOS on...
Ferrell, Jessica M Pathak, Preeti Boehme, Shannon Gilliland, Tricia Chiang, John Y L
Published in
Hepatology (Baltimore, Md.)
Activation of the nuclear bile acid receptor farnesoid X receptor (FXR) protects against hepatic inflammation and injury, while Takeda G protein-coupled receptor 5 (TGR5) promotes adipose tissue browning and energy metabolism. Here, we examined the physiological and metabolic effects of the deficiency of these two bile acid receptors on hepatic met...
D’Elia, Riccardo V. Goodchild, Sarah A. Winder, Catherine L. Southam, Andrew D. Weber, Ralf J. M. Stahl, Fiona M. Docx, Cerys Patel, Vikesh Green, A. Christopher Viant, Mark R.
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Published in
Metabolomics
IntroductionExposure to ricin can be lethal and treatments that are under development have short windows of opportunity for administration after exposure. It is therefore essential to achieve early detection of ricin exposure to provide the best prognosis for exposed individuals. Ricin toxin can be detected in clinical samples via several antibody-...
Liu, Yang Li, Qi Wang, Hualin Zhao, Xiuju Li, Na Zhang, Hongyu Chen, Guoxun Liu, Zhiguo
Published in
The Journal of nutritional biochemistry
Our previous studies have found that fish oil rich in ω-3 polyunsaturated fatty acids (ω-3 PUFA) protects against non-alcoholic fatty liver disease (NAFLD) in mice. This study was aimed to explore the effects of fish oil on high fat diet (HFD)-induced circadian bile composition chaos. Male C57BL/6 mice were randomly divided into three groups, a con...
van de Peppel, Ivo P Doktorova, Marcela Berkers, Gitte de Jonge, Hugo R Houwen, Roderick H J Verkade, Henkjan J Jonker, Johan W Bodewes, Frank A J A
Published in
Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society
Disruption of the enterohepatic circulation of bile acids (BAs) is part of the gastrointestinal phenotype of cystic fibrosis (CF). Ivacaftor (VX-770), a cystic fibrosis transmembrane conductance regulator (CFTR) potentiator, improves pulmonary function in CF patients with class III gating mutations. We studied the effect of ivacaftor on the enteroh...
Cariello, Marica Piglionica, Marilidia Gadaleta, Raffaella Maria Moschetta, Antonio
Published in
Handbook of experimental pharmacology
The endocrine fibroblast growth factors (FGFs), FGF19, FGF21, and FGF23, play a key role in whole-body homeostasis. In particular, FGF19 is a postprandial hormone regulating glucose homeostasis, glycogen and protein synthesis, and primary bile acid (BA) metabolism. In the ileum, BA-dependent farnesoid X receptor (FXR) activation induces the product...
Ding, Lin Chang, Mengru Guo, Ying Zhang, Lingyu Xue, Changhu Yanagita, Teruyoshi Zhang, Tiantian Wang, Yuming
Published in
Lipids in Health and Disease
BackgroundRecently, trimethylamine-N-oxide (TMAO) plasma levels have been proved to be associated with atherosclerosis development. Among the targets aimed to ameliorating atherosclerotic lesions, inducing bile acid synthesis to eliminate excess cholesterol in body is an effective way. Individual bile acid as endogenous ligands for the nuclear rece...
