Increased Expression of S100B and RAGE in a Mouse Model of Bile Duct Ligation-induced Liver Fibrosis
...Published in Journal of Korean Medical Science
Therapeutic Effect of Glycyrrhizin Arginine Salt on Rat Cholestatic Cirrhosis and its Mechanism.
Published in The American journal of Chinese medicine
To investigate the therapeutic effect of glycyrrhizin arginine salt on rat cholestatic cirrhosis, we subjected male Sprague Dawley rats to common bile duct ligation for 14 days and treated them with distilled water (model group), arginine, or a low or high dose of glycyrrhizin arginine salt by gavage. A sham-operated group was used as a control gro...
Atorvastatin does not protect against ischemia-reperfusion damage in cholestatic rat livers
Published in BMC Surgery
BackgroundExtrahepatic cholestasis sensitizes the liver to ischemia/reperfusion (I/R) injury during surgery for perihilar cholangiocarcinoma. It is associated with pre-existent sterile inflammation, microvascular perfusion defects, and impaired energy status. Statins have been shown to protect against I/R injury in normal and steatotic mouse livers...
Aqueous Garlic Extract Alleviates Liver Fibrosis and Renal Dysfunction in Bile-Duct-Ligated Rats
Published in Zeitschrift für Naturforschung C
There is accumulating evidence that the renin-angiotensin system (RAS) is involved in hepatic inflammation and fibrogenesis. Garlic was found to lower the activity of the angiotensin converting enzyme (ACE) in the serum of rats in a diabetic model. We examined the effect of an aqueous garlic extract (AGE) on the ACE activity, cholestasis-induced li...
In vivo and ex vivo effects of propofol on myocardial performance in rats with obstructive jaundice
Published in BMC Gastroenterology
BackgroundResponsiveness of the "jaundiced heart" to propofol is not completely understood. The purpose of this study was to evaluate the effect of propofol on myocardial performance in rats with obstructive jaundice.MethodsMale Sprague-Dawley rats (n = 40) were randomly allocated into two groups, twenty underwent bile duct ligation (BDL), and 20 u...
What is new in the liver sinusoids? meeting report, 16th International Symposium on Cells of the Hepatic Sinusoid (ISCHS...
Published in Fibrogenesis & Tissue Repair
The 16th International Symposium on Cells of the Hepatic Sinusoid (ISCHS) took place in Florence, Italy on 22-24 September 2011. This symposium is a multidisciplinary meeting where new and important findings on the biology of liver cells are presented and discussed.
Endotoxin and CD14 in the progression of biliary atresia
Published in Journal of Translational Medicine
BackgroundBiliary atresia (BA) is a typical cholestatic neonatal disease, characterized by obliteration of intra- and/or extra-hepatic bile ducts. However, the mechanisms contributing to the pathogenesis of BA remain uncertain. Because of decreased bile flow, infectious complications and damaging endotoxemia occur frequently in patients with BA. Th...
Expression of hepatocytic- and biliary-specific transcription factors in regenerating bile ducts during hepatocyte-to-bi...
Published in Comparative Hepatology
BackgroundUnder compromised biliary regeneration, transdifferentiation of hepatocytes into biliary epithelial cells (BEC) has been previously observed in rats, upon exposure to BEC-specific toxicant methylene dianiline (DAPM) followed by bile duct ligation (BDL), and in patients with chronic biliary liver disease. However, mechanisms promoting such...
Toll-like receptor 4 signaling in liver injury and hepatic fibrogenesis
Published in Fibrogenesis & Tissue Repair
Toll-like receptors (TLRs) are a family of transmembrane pattern recognition receptors (PRR) that play a key role in innate and adaptive immunity by recognizing structural components unique to bacteria, fungi and viruses. TLR4 is the most studied of the TLRs, and its primary exogenous ligand is lipopolysaccharide, a component of Gram-negative bacte...
The multifaceted role of pirfenidone and its novel targets
Published in Fibrogenesis & Tissue Repair
BackgroundPirfenidone (PFD) is a molecule that exhibits antifibrotic properties in a variety of in vitro and animal models of lung, liver and renal fibrosis. These pathologies share many fibrogenic pathways with an abnormal fibrous wound-healing process; consequently, tissue repair and tissue regeneration-regulating mechanisms are altered.Objective...
