Continuing our research into the anticancer properties of acrylonitriles, we present a study involving the design, synthesis, computational analysis, and biological assessment of novel acrylonitriles derived from methoxy, hydroxy, and N-substituted benzazole. Our aim was to examine how varying the number of methoxy and hydroxy groups, as well as th...
COVID-19 infection is associated with a variety of vascular occlusive morbidities. However, a comprehensive understanding of how this virus can induce vascular complications remains lacking. Here, we show that a peptide fragment of SARS-CoV-2 spike protein, S192 (sequence 192-211), is capable of forming amyloid-like aggregates that can induce agglu...
PURPOSE: To investigate the impact of reduced injected doses on the quantitative and qualitative assessment of the amyloid PET tracers [18F]flutemetamol and [18F]florbetaben. METHODS: Cognitively impaired and unimpaired individuals (N = 250, 36% Aβ-positive) were included and injected with [18F]flutemetamol (N = 175) or [18F]florbetaben (N = 75). P...
Published in Chemistry (Weinheim an der Bergstrasse, Germany)
We present here a joint experimental and computational study on the formation of benzothiazoles. Our investigation reveals a green protocol for accessing benzothiazoles from acyl chlorides using either water alongside a reducing agent as the reaction medium or in combination with stoichiometric amounts of a weak acid, instead of the harsh condition...
Acknowledgements: This work was funded by a Cancer Research UK (CRUK) Advanced Clinician Scientist Award (C60100/A23916) to S.N.-Z., a Dr. Josef Steiner Cancer Research Award 2019 to S.N.-Z., a Basser Gray Prime Award 2020 to S.N.-Z., a CRUK Pioneer Award (C60100/A23433) to S.N.-Z., a CRUK Grand Challenge Award (C60100/A25274) to S.N.-Z., a CRUK Ea...
This document is the Accepted Manuscript version of a Published Work that appeared in final form in ACS Sustainable Chemistry & Engineering, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://doi.org/10.1021/acssuschemeng.3c01489. / [EN] Establish...
Published in Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy
In this work, a new benzothiazole azo dye sensor (BTS) was synthesized, and its cation binding affinity was studied using the colorimetric method, UV-vis, and 1H NMR spectral data. The results revealed that the sensor BTS exhibits a remarkable tendency for Pb2+ ion to perform spontaneous visual color change from blue (BTS) to pink (BTS + Pb2+), wit...
Seafood consumption has become a potential exposure route towards high production volume chemicals (HPVs) due to the pathway of these compounds reaching the aquatic environment via industrial and domestic discharges. The present study focuses on the determination of phthalate esters (PAEs), organophosphate esters (OPEs), benzothiazoles (BTs), benzo...
Soluble epoxide hydrolase (sEH) and fatty acid amide hydrolase (FAAH) are potential targets for several diseases. Previous studies have reported that concomitant selective inhibition of sEH and FAAH produced antinociception effects in an animal model of pain. However, the co-administration of a selective sEH inhibitor and a selective FAAH inhibitor...
Published in The Science of the total environment
People are extensively exposed to benzotriazoles (BTRs) and benzothiazoles (BTHs) derivatives, which are environmental pollutants that may possess endocrine-disrupting potential; however, no epidemiological evidence is available on the associations of BTRs and BTHs with estrogens and androgens. This study aimed at investigating the associations of ...
