Published in Journal of Proteomics
Abstract Protein glycosylation is a common post-translational modification that is involved in many biological processes, including cell adhesion, protein–protein and receptor-ligand interactions. The glycoproteome constitutes a source for identification of disease biomarkers since altered protein glycosylation profiles are associated with certain ...
In this study, 22 phenolic compounds were investigated to inhibit the angiotensin-converting enzyme (ACE). Tannic acid showed the highest activity (IC50 = 230 mu M). The IC50 values obtained for phenolic acids and flavonoids ranged between 0.41 and 9.3 mM. QSAR analysis confirmed that the numbers of hydroxyl groups on the benzene ring play an impor...
Achieving (bio) macromolecular structural assignment from the interpretation of ion mobility spectrometry (IMS) experiments requires successful comparison with computer modeling. Replica-exchange molecular dynamics simulations with suitable force fields not only offer a convenient framework to locate relevant conformations, especially in the case o...
Fogarty International Center-NIH [D43-TW007129]
German Ministry of Education and Science [BRA09/014]
FAPESP, Brazil [Proc. 2010-17465-8]