Silagi, Elizabeth S Novais, Emanuel J Bisetto, Sara Telonis, Aristeidis G Snuggs, Joseph Le Maitre, Christine L Qiu, Yunping Kurland, Irwin J Shapiro, Irving M Philp, Nancy J
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Published in
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
Maintenance of glycolytic metabolism is postulated to be required for health of the spinal column. In the hypoxic tissues of the intervertebral disc and glycolytic cells of vertebral bone, glucose is metabolized into pyruvate for ATP generation and reduced to lactate to sustain redox balance. The rise in intracellular H+ /lactate concentrations are...
Ackerman, Kathryn E Singhal, Vibha Slattery, Meghan Eddy, Kamryn T Bouxsein, Mary L Lee, Hang Klibanski, Anne Misra, Madhusmita
Published in
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
Oligoamenorrheic athletes (OAs) have lower bone mineral density (BMD) and greater impairment of bone microarchitecture, and therefore higher fracture rates compared to eumenorrheic athletes. Although improvements in areal BMD (aBMD; measured by dual-energy X-ray absorptiometry) in OAs have been demonstrated with transdermal estrogen treatment, effe...
Suominen, Tuuli H Edgren, Johanna Salpakoski, Anu Arkela, Marja Kallinen, Mauri Cervinka, Tomas Rantalainen, Timo Törmäkangas, Timo Heinonen, Ari Sipilä, Sarianna
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JBMR Plus
Weight‐bearing physical activity may decrease or prevent bone deterioration after hip fracture. This study investigated the effects of a home‐based physical rehabilitation program on tibial bone traits in older hip fracture patients. A population‐based clinical sample of men and women operated for hip fracture (mean age 80 years, 78% women) was ran...
Emami, Armaun J Toupadakis, Chrisoula A Telek, Stephanie M Fyhrie, David P Yellowley, Clare E Christiansen, Blaine A
Published in
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
The most reliable predictor of future fracture risk is a previous fracture of any kind. The etiology of this increased fracture risk is not fully known, but it is possible that fracture initiates systemic bone loss, leading to greater fracture risk at all skeletal sites. In this study, we investigated systemic bone loss and recovery after femoral f...
Cheng, Albert Krishnan, Laxminarayanan Tran, Lisa Stevens, Hazel Y Xia, Boao Lee, Nari Williams, Joseph K Gibson, Greg Guldberg, Robert E
Published in
JBMR Plus
Age is a well‐known influential factor in bone healing, with younger patients generally healing bone fractures more rapidly and suffering fewer complications compared with older patients. Yet the impact age has on the response to current bone healing treatments, such as delivery of bone morphogenetic protein 2 (BMP‐2), remains poorly characterized....
Gagnon, Claudia Schafer, Anne L
Published in
JBMR plus
Bariatric surgery results in long-term weight loss and improvement or resolution in obesity-related comorbidities. However, mounting evidence indicates that it adversely affects bone health. This review summarizes clinical research findings about the impact of bariatric surgery on skeletal outcomes. The literature is the largest and strongest for t...
Ko, Frank C Van Vliet, Miranda Ellman, Rachel Grasso, Daniel Brooks, Daniel J Spatz, Jordan M Conlon, Chrissy Aguirre, J Ignacio Wronski, Thomas J Bouxsein, Mary L
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Published in
JBMR plus
Previous work has shown that the soluble murine BMPR1A-fusion protein (mBMPR1A-mFc) binds to BMP2 and BMP4 with high affinity, preventing downstream signaling. Further, treatment of intact and ovariectomized mice with mBMPR1A-mFc leads to increased bone mass, and improved bone microarchitecture and strength, via increased bone formation and reduced...
McMichael, Brooke K Jeong, Yong-Hoon Auerbach, Justin A Han, Cheol-Min Sedlar, Ryan Shettigar, Vikram Bähler, Martin Agarwal, Sudha Kim, Do-Gyoon Lee, Beth S
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Published in
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
The Ras homolog A (RhoA) subfamily of Rho guanosine triphosphatases (GTPases) regulates actin-based cellular functions in bone such as differentiation, migration, and mechanotransduction. Polymorphisms or genetic ablation of RHOA and some of its regulatory guanine exchange factors (GEFs) have been linked to poor bone health in humans and mice, but ...
Tsai, Joy N Nishiyama, Kyle K Lin, David Yuan, Amy Lee, Hang Bouxsein, Mary L Leder, Benjamin Z
Published in
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
In postmenopausal osteoporosis, switching from teriparatide to denosumab results in continued bone mineral density (BMD) gains whereas switching from denosumab to teriparatide results in BMD loss. To assess the effects of these transitions on bone microarchitecture and strength, we performed high-resolution peripheral QCT (HR-pQCT) at the distal ti...
Nielson, Carrie M Liu, Ching-Ti Smith, Albert V Ackert-Bicknell, Cheryl L Reppe, Sjur Jakobsdottir, Johanna Wassel, Christina Register, Thomas C Oei, Ling Alonso, Nerea
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Published in
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
Genome-wide association studies (GWASs) have revealed numerous loci for areal bone mineral density (aBMD). We completed the first GWAS meta-analysis (n = 15,275) of lumbar spine volumetric BMD (vBMD) measured by quantitative computed tomography (QCT), allowing for examination of the trabecular bone compartment. SNPs that were significantly associat...
