Azimi, Parham Keshavarz, Zahra Lahaie Luna, Marianne Cedeno Laurent, Jose Guillermo Vallarino, Jose Christiani, David C Allen, Joseph G
Published in
International journal of environmental research and public health
Up to 95% of the liquid volume in an e-cigarette consists of propylene glycol. Previous research has shown that propylene glycol can generate diacetyl and formaldehyde when heated. New research shows that propylene glycol can also generate methylglyoxal, an alpha di-carbonyl compound recently shown to cause epithelial necrosis at even lower concent...
Scheenstra, Maaike R Martínez-Botía, Patricia Acebes-Huerta, Andrea Brouwer, Rutger W W Caballero-Sánchez, Noemí Gillemans, Nynke De Bleser, Pieter Nota, Benjamin De Cuyper, Iris M Salunkhe, Vishal
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Published in
Journal of leukocyte biology
Dendritic cells (DCs) are key immune modulators and are able to mount immune responses or tolerance. DC differentiation and activation imply a plethora of molecular and cellular responses, including transcriptional changes. PU.1 is a highly expressed transcription factor in DCs and coordinates relevant aspects of DC biology. Due to their role as im...
González-Santamaría, Jhonatan Arámburo-Gálvez, Jesús Gilberto Beltrán-Cárdenas, Carlos Eduardo Mora-Melgem, José Antonio Figueroa-Salcido, Oscar Gerardo Ramírez-Torres, Giovanni Isaí Cárdenas-Torres, Feliznando Isidro Carvalho Gomes, Itallo Geralda André, Tatiane Macêdo-Callou, María Auxiliadora
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Published in
Healthcare (Basel, Switzerland)
There are no epidemiological data about food-dependent exercise-induced anaphylaxis (FDEIA) in Latin America. Our aim was to design, assess, and validate a questionnaire to identify potential FDEIA cases and/or estimate its prevalence by self-report. Questions were included in the instrument to address the main symptoms of FDEIA, type/intensity of ...
Belessiotis-Richards, A Higgins, S Sansom, MSP Alexander-Katz, A Stevens, M
Nanoscale membrane curvature is a common feature in cell biology required for functions such as endocytosis, exocytosis and cell migration. These processes require the cytoskeleton to exert forces on the membrane to deform it. Cytosolic proteins contain specific motifs which bind to the membrane, connecting it to the internal cytoskeletal machinery...
Van der Meeren, Louis Verduijn, Joost Krysko, Dmitri Skirtach, Andre
Regulated cell death (RCD) has a fundamental role in development, pathology, and tissue homeostasis. In order to understand the RCD mechanisms, it is essential to follow these processes in real time. Here, atomic force microscopy (AFM) is applied to morphologically and mechanically characterize four RCD modalities (intrinsic and extrinsic apoptosis...
Watts, EL Fensom, GK Byrne, KS Perez-Cornago, A Allen, NE Knuppel, A Gunter, MJ Holmes, M Martin, RM Murphy, N
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Insulin‐like growth factor‐I (IGF‐I) and testosterone have been implicated in prostate cancer aetiology. Using data from a large prospective full‐cohort with standardised assays and repeat blood measurements, and genetic data from an international consortium, we investigated the associations of circulating IGF‐I, sex hormone‐binding globulin (SHBG)...
Ranger, A Gaspar, M Elkhatteb, A Jackson, T Fox, S Aw, TC Vipond, L Cotterill, J Ghori, A Laffan, M
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Bleeding is a significant complication of cardiopulmonary bypass (CPB), despite routine anticoagulation monitoring. This is likely to be multifactorial. In this prospective, single‐centre cohort study of 30 patients undergoing CPB surgery, our aim was to characterise the changes in von Willebrand factor (VWF) function, platelet interaction and the ...
van Cann, Marianne; Kuzmenkov, Alexey; Isensee, Jorg; Andreev-Andrievskiy, Alexander; Peigneur, Steve; 56122; Khusainov, Georgii; Berkut, Antonina; Tytgat, Jan; 18354; Vassilevski, Alexander; Hucho, Tim;
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Venoms are a rich source of highly specific toxins, which allow the identification of novel therapeutic targets. We have now applied high content screening (HCS) microscopy to identify toxins that modulate pain sensitization signaling in primary sensory neurons of rat and elucidated the underlying mechanism. A set of venoms and fractions thereof we...
Kim, Jinuk Han, Wonhee Park, Taeyong Kim, Eun Jin Bang, Injin Lee, Hyun Sik Jeong, Yejing Roh, Kyeonghwan Kim, Jeesoo Kim, Jong-Seo
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Low-density lipoprotein receptor-related protein 6 (LRP6) is a coreceptor of the beta -catenin-dependent Wnt signaling pathway. The LRP6 ectodomain binds Wnt proteins, as well as Wnt inhibitors such as sclerostin (SOST), which negatively regulates Wnt signaling in osteocytes. Although LRP6 ectodomain 1 (E1) is known to interact with SOST, several u...
Zhang, Libang; Zhang, Dongjian; Gao, Meng; Jin, Qiaomei; Jiang, Cuihua; Wu, Tianze; Feng, Yuanbo; Ni, Yicheng; 14498; Yin, Zhiqi; Zhang, Jian;
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PURPOSE: Visualization of tumor necrosis can determine tumor response to therapy. Our previous study showed that the rhein-based magnetic resonance imaging (MRI) contrast agent with alkane linker (GdL2) could clearly image tumor necrosis. However, its water solubility and cell safety needed to be improved. Herein, three rhein-based MRI agents with ...
