Variceal bleeding is a consequence of severe portal hypertension in patients with liver cirrhosis. Although the rate of bleeding has decreased over time, variceal bleeding in the presence of acute-on-chronic liver failure (ACLF) carries a high risk of treatment failure and short-term mortality. Treatment and/or removal of precipitating events (main...
BACKGROUND: Atrial fibrillation (AF) is common in heart failure (HF), is associated with worse outcomes compared with sinus rhythm, and may modify the effects of therapy. OBJECTIVES: This study examined the effects of dapagliflozin according to the presence or not of AF in the DELIVER (Dapagliflozin Evaluation to Improve the LIVEs of Patients With ...
Published in Healthcare (Basel, Switzerland)
This case study aimed to investigate the short-term effects of ankle eversion taping (AET) using kinesiology tape on bilateral acute ankle inversion sprains in an amateur college soccer goalkeeper. Ankle eversion taping was applied for two weeks (average 16 h/day) on a 24-year-old goalkeeper with bilateral grade 2 acute ankle inversion sprain with ...
BACKGROUND: Beta-2 adrenergic receptor (ADRB2) mediates proliferation and treatment resistance in preclinical models of human epidermal growth factor receptor 2 positive (HER2+) breast cancer. We evaluated ADRB2 gene expression as a prognostic and predictive biomarker in patients with HER2+ early breast cancer. METHODS: ADRB2 expression was retriev...
AIMS: In patients with catecholaminergic polymorphic ventricular tachycardia (CPVT), implantable cardioverter-defibrillator (ICD) shocks are sometimes ineffective and may even trigger fatal electrical storms. We assessed the efficacy and complications of ICDs placed in patients with CPVT who presented with a sentinel event of sudden cardiac arrest ...
Published in Environmental toxicology and chemistry
To estimate mixture effects caused by the high number of chemicals simultaneously present in the environment, methods for routine effect assessment of environmentally realistic contaminant mixtures are needed. We repeatedly exposed the marine diatom Phaeodactylum tricornutum to SpeediskTM passive sampler extracts and observed statistically signific...
Published in Current opinion in critical care
These new insights will help to better tailor individual strategies to prevent or minimize perioperative cardiac complications. Especially, early diagnosis and intensification of treatment will get specific interest in the coming years.
Recently a mouse skin carcinogenesis study reported that a beta-blocker carvedilol displayed antitumor-properties via antihyperplastic effects. However, the antihyperplastic mechanism is unclear as the beta-blocker is characterized with multiple pleiotropic effects including stimulation of endothelial NO release and verapamil-like calcium channel b...
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