Cararo-Lopes, Marina Minto Sadovnik, Ratchell Fu, Allen Suresh, Shradha Gandu, Srinivasa Firestein, Bonnie L
Published in
Molecular neurobiology
α-Klotho (α-Kl) is a modulator of aging, neuroprotection, and cognition. Transcription of the Klotho gene produces two splice variants-a membrane protein (mKl), which can be cleaved and released into the extracellular milieu, and a truncated secreted form (sKl). Despite mounting evidence supporting a role for α-Kl in brain function, the specific ro...
mclellan, kristine sabbagh, sima takahashi, momoko hong, hui wang, yuan sanchez, jason tait
Neurotrophins are proteins that mediate neuronal development using spatiotemporal signaling gradients. The chicken nucleus magnocellularis (NM), an analogous structure to the mammalian anteroventral cochlear nucleus, provides a model system in which signaling between the brain-derived neurotrophic factor (BDNF) and tyrosine receptor kinase B (TrkB)...
choi, in-ae yun, hee lee, jongmin choi, dong-hee
This study explores the neuroprotective effects of neuropeptide FF (NPFF, FLFQPQRFamide) in the context of ischemic injury. Based on transcriptomic analysis in stroke models treated with 5-Aza-dC and task-specific training, we identified significant gene expression changes, particularly involving NPFF. To further explore NPFF’s role in promoting ne...
liberona, andrés jones, natalia zúñiga, karen garrido, verónica zelada, mario ignacio silva, hernán nieto, rodrigo r.
Brain-derived neurotrophic factor (BDNF) is a potential biomarker of response to treatment in psychiatric disorders. As it plays a role in the pathophysiological development of schizophrenia and bipolar disorder, it is of interest to study its role in predicting therapeutic responses in both conditions. We carried out a systematic review of the lit...
Liu, Yaqi Fu, Xiying Zhao, Xing Cui, Ranji Yang, Wei
Published in
Frontiers in Pharmacology
The complexity of depression presents a significant challenge to traditional treatment methods, such as medication and psychotherapy. Recent studies have shown that exercise can effectively reduce depressive symptoms, offering a new alternative for treating depression. However, some depressed patients are unable to engage in regular physical activi...
Rabelo, Thallita K Campos, Ana Carolina P Almeida Souza, Thiago H Mahmud, Faiza Popovic, Milos R Covolan, Luciene Betta, Victor H C DaCosta, Leodante Lipsman, Nir Diwan, Mustansir
...
Published in
Brain stimulation
Traumatic brain injury (TBI) is a major life-threatening event. In addition to neurological deficits, it can lead to long-term impairments in attention and memory. Deep brain stimulation (DBS) is an established therapy for movement disorders that has been recently investigated for memory improvement in various disorders. In models of TBI, stimulati...
Giesler, Lauren P Mychasiuk, Richelle Shultz, Sandy R McDonald, Stuart J
Published in
The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry
Traumatic brain injury is a common health problem affecting millions of people each year. BDNF has been investigated in the context of traumatic brain injury due to its crucial role in maintaining brain homeostasis. Val66Met is a functional single-nucleotide polymorphism that results in a valine-to-methionine amino acid substitution at codon 66 in ...
turovskaya, maria v. gavrish, maria s. tarabykin, viktor s. babaev, alexei a.
Since genetic mutations during brain development play a significant role in the genesis of epilepsy, and such genetically determined epilepsies are the most difficult to treat, there is a need to study the mechanisms of epilepsy development with deletions of various transcription factors. We utilized heterozygous mice (Sip1wt/fl) with a neuronal de...
flores-ramos, mónica vega-rosas, andrés palomera-garfias, nadia saracco-alvarez, ricardo ramírez-rodríguez, gerardo bernabé
Antidepressant response is a multifactorial process related to biological and environmental factors, where brain-derived neurotrophic factor (BDNF) may play an important role in modulating depressive and anxious symptoms. We aimed to analyze how BDNF impacts antidepressant response, considering the levels of anxiety. Methods: A total of 40 depresse...
Mishra, Pinki Bhurani, Dinesh Nidhi,
Published in
Frontiers in Neurology
Objective Depression is the most commonly observed psychological manifestation experienced by individuals diagnosed with cancer. The purpose of the study was to investigate the association between levels of IL-4, BDNF, neopterin, and depressive symptoms in lymphoma patients receiving consecutive cycles of chemotherapy. Methods Newly diagnosed lymph...