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Lin, Shu-Fu Lee, Yi-Yin Wu, Ming-Hsien Lu, Yu-Ling Yeh, Chun-Nan Chen, Wei-Yi Chou, Ting-Chao Wong, Richard J
Published in
Endocrine-related cancer
Ataxia telangiectasia and Rad3-related protein (ATR) is a critical component of the DNA damage response and a potential target in the treatment of cancers. An ATR inhibitor, BAY 1895344, was evaluated for its use in differentiated thyroid cancer (DTC) therapy. BAY 1895344 inhibited cell viability in four DTC cell lines (TPC1, K1, FTC-133, and FTC-2...
Sundararajan, Vignesh Tan, Tuan Zea Lim, Diana Peng, Yanfen Wengner, Antje Margret Ngoi, Natalie Yan Li Jeyasekharan, Anand D Tan, David Shao Peng
Published in
The Journal of pathology
Excessive genomic instability coupled with abnormalities in DNA repair pathways induces high levels of 'replication stress' when cancer cells propagate. Rather than hampering cancer cell proliferation, novel treatment strategies are turning their attention towards targeting cell cycle checkpoint kinases (such as ATR, CHK1, WEE1, and others) along t...
