Published in Biochimie
It is becoming obvious that in addition to aging and various hearth pathologies, excess of body weight, especially obesity is a major risk factor for severity of COVID-19 infection. Intriguingly the receptor for SARS-CoV-2 is ACE2, a member of the angiotensin receptor family that has a relatively large tissue distribution. This observation likely e...
Published in Molecular metabolism
Aging and chronic glucocorticoid excess share a number of critical features, including the development of central obesity, insulin resistance and osteoporosis. Previous studies have shown that skeletal glucocorticoid signalling increases with aging and that osteoblasts mediate the detrimental skeletal and metabolic effects of chronic glucocorticoid...
Published in Molecular Metabolism
• Adipocytes after HFD intake exhibit defects in cellular identity maintenance. • Adipocytes develop actin filament networks in obesity. • Altered PPAR γ activity mediates defective adipocyte identity phenotypes. • TGFβ-SMAD pathways promote HFD-induced aberrant phenotype of adipocytes.
Published in Molecular Metabolism
• Wnt/β-catenin signaling regulates lipogenesis and lipid unsaturation in adipocytes. • Effects on lipogenesis are mediated in part by the regulation of Mlxipl and Srebf1. • Loss of adipocyte β-catenin is defended by CD45-/CD31- cells in chow-fed mice. • β-cat −/− mice are protected from diet-induced obesity and metabolic dysfunction.
Published in Molecular Metabolism
• Impaired temperature maintenance in mice deficient in adipocyte STAT5 after acute cold exposure. • Blocked β3-adrenergic induction of lipolysis and PKA activity in BAT upon STAT5 deficiency. • Reduced respiratory capacity in primary differentiated brown adipocytes lacking STAT5. • Diminished brown remodeling of STAT5 deficient ScWAT after chronic...
Published in Cellular and Molecular Gastroenterology and Hepatology
Published in Molecular Metabolism
• Dual PPARα/γ activators robustly induce browning of white fat in vitro and in vivo . • PPARγ action alone is sufficient to convert white into brown-like adipocytes in vitro . • Dual PPARα/γ activators are superior to PPARγ activators for browning of white fat in vivo . • PPARγ action in adipose and PPARα-mediated increase in FGF21 synergize to in...
Published in Redox Biology
• Basal glucose uptake in human adipocytes is improved by solely elevating UCP1 levels. • Adipogenic, metabolic and mitochondrial gene expressions were not affected by UCP1 overexpression. • UCP1-driven increase in glucose uptake is mediated by GLUT1.
Published in Biochemistry and biophysics reports
Breast cancer remains a substantial clinical problem worldwide, and cancer-associated cachexia is a condition associated with poor prognosis in this and other malignancies. Adipose tissue is involved in the development and progression of cancer-associated cachexia, but its various roles and mechanisms of action are not completely defined, especiall...
Published in Redox biology
Peroxisomes are ubiquitous cellular organelles required for specific pathways of fatty acid oxidation and lipid synthesis, and until recently their functions in adipocytes have not been well appreciated. Importantly, peroxisomes host many oxygen-consumption reactions and play a major role in generation and detoxification of reactive oxygen species ...
