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Waelchli, Thomas; Ghobrial, Moheb; Schwab, Marc; Takada, Shigeki; Zhong, Hang; Suntharalingham, Samuel; Vetiska, Sandra; Gonzalez, Dayme Rodrigues; Wu, Ruilin; Rehrauer, Hubert;
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A broad range of brain pathologies critically relies on the vasculature, and cerebrovascular disease is a leading cause of death worldwide. However, the cellular and molecular architecture of the human brain vasculature remains incompletely understood1. Here we performed single-cell RNA sequencing analysis of 606,380 freshly isolated endothelial ce...
Kip, Elodie Staal, Jens Verstrepen, Lynn Tima, HG Terryn, S Romano, M Lemeire, Kelly Suin, V Hamouda, A Kalai, M
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MALT1 is involved in the activation of immune responses, as well as in the proliferation and survival of certain cancer cells. MALT1 acts as a scaffold protein for NF-kappa B signaling and a cysteine protease that cleaves substrates, further promoting the expression of immunoregulatory genes. Deregulated MALT1 activity has been associated with auto...
Loryan, Irena Sinha, Vikash Mackie, Claire Van Peer, Achiel Drinkenburg, Wilhelmus H Vermeulen, An Heald, Donald Hammarlund-Udenaes, Margareta Wassvik, Carola M
Published in
Molecular pharmaceutics
In the present work we sought to gain a mechanistic understanding of the physicochemical properties that influence the transport of unbound drug across the blood-brain barrier (BBB) as well as the intra- and extracellular drug exposure in the brain. Interpretable molecular descriptors that significantly contribute to the three key neuropharmacokine...
Verbeken, Mathieu Wynendaele, Evelien Mauchauffée, Elodie Bracke, Nathalie Stalmans, Sofie Bojnik, Engin Benyhe, Sandor Peremans, Kathelijne Polis, Ingeborgh Burvenich, Christian
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Enkephalins are active in regulation of nociception in the body and are key in development of new synthetic peptide analogs that target centrally located opioid receptors. In this study, we investigated the in vivo blood-brain barrier (BBB) penetration behavior and antinociceptive activity of two cyclic enkephalin analogs with a thiourea (CycS) or ...
De Bock, Marijke Culot, Maxime Wang, Nan da Costa, Anaelle Decrock, Elke Bol, Mélissa Bultynck, Geert Cecchelli, Romeo Leybaert, Luc