Sheel, Ankur Shao, Rong Brown, Christine Johnson, Joanne Hamilton, Alexandra Sun, Danhui Oppenheimer, Julia Smith, Wendy Visconti, Pablo E. Markstein, Michele
...
Published in
Frontiers in Cell and Developmental Biology
The term programmed cell death (PCD) was coined in 1965 to describe the loss of the intersegmental muscles (ISMs) of moths at the end of metamorphosis. While it was subsequently demonstrated that this hormonally controlled death requires de novo gene expression, the signal transduction pathway that couples hormone action to cell death is largely un...
Chan, Yu-Tzu Lai, Alan C-Y Lin, Ruey-Jen Wang, Ya-Hui Wang, Yi-Ting Chang, Wen-Wei Wu, Hsin-Yi Lin, Yu-Ju Chang, Wen-Ying Wu, Jen-Chine
...
G protein-coupled estrogen receptor-1 (GPER), a member of the G protein-coupled receptor (GPCR) superfamily, mediates estrogen-induced proliferation of normal and malignant breast epithelial cells. However, its role in breast cancer stem cells (BCSCs) remains unclear. Here we showed greater expression of GPER in BCSCs than non-BCSCs of three patien...
Voss, Anne K. Strasser, Andreas
Published in
F1000Research
Apoptotic cells are commonly observed in a broad range of tissues during mammalian embryonic and fetal development. Specific requirements and functions of programmed cell death were inferred from early observations. These inferences did not hold up to functional proof for a requirement of apoptosis for normal tissue development in all cases. In thi...
Duan, Tianying Cil, Onur Tse, C Ming Sarker, Rafiquel Lin, Ruxian Donowitz, Mark Verkman, Alan S
Published in
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Bile acid diarrhea (BAD) is common with ileal resection, Crohn's disease, and diarrhea-predominant irritable bowel syndrome. Here, we demonstrate the efficacy of cystic fibrosis transmembrane conductance regulator (CFTR) inhibitor (R)-benzopyrimido-pyrrolo-oxazine-dione-27 (BPO-27) in reducing bile acid-induced fluid and electrolyte secretion in co...
Zhang, Jiachao Sun, Zhihong Jiang, Shuaiming Bai, Xiaoye Ma, Chenchen Peng, Qiannan Chen, Kaining Chang, Haibo Fang, Tuanyu Zhang, Heping
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Published in
mSystems
Although a few studies have investigated the intestinal microbiota of women with polycystic ovary syndrome (PCOS), the functional and metabolic mechanisms of the microbes associated with PCOS, as well as potential microbial biomarkers, have not yet been identified. To address this gap, we designed a two-phase experiment in which we performed shotgu...
Chan, Yu‐Tzu Lai, Alan C.‐Y. Lin, Ruey‐Jen Wang, Ya‐Hui Wang, Yi‐Ting Chang, Wen‐Wei Wu, Hsin‐Yi Lin, Yu‐Ju Chang, Wen‐Ying Wu, Jen‐Chine
...
Published in
International Journal of Cancer
What's new? G protein‐coupled estrogen receptor‐1 (GPER) mediates estrogen‐induced proliferation of normal and malignant breast epithelial cells. However, the role of GPER in breast cancer stem cells (BCSC) biology remains unclear. Here, using patient‐derived xenografts of ER–/PR+ breast cancer, the authors found higher expression of GPER in BCSCs ...
Yu, Xiaoyu Man, Rongjun Li, Yanan Yang, Qianqian Li, Hongrui Yang, Huiming Bai, Xiaohui Yin, Haiyan Li, Jianfeng Wang, Haibo
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Published in
Journal of cellular and molecular medicine
The objective of this study was to elucidate whether paeoniflorin (PF) exerted an effect on cisplatin-induced spiral ganglion neuron (SGN) damage, with special attention given to the role of PINK1/BAD pathway in this process. Middle cochlear turn culture and C57BL/6 mice were utilized to identify the character of PF in vitro and in vivo. We found t...
Tarokhian, Hanieh Rahimi, Hossein Mosavat, Arman Shirdel, Abbas Rafatpanah, Houshang Akbarin, Mohammad Mehdi Bari, Alireza Ramezani, Samaneh Rezaee, Seyed Abdolrahim
Published in
BMC Cancer
BackgroundAdult T-cell leukemia/lymphoma (ATLL) is a lymphoproliferative disorder of HTLV-1-host interactions in infected TCD4+ cells. In this study, the HTLV-1 proviral load (PVL) and HBZ as viral elements and AKT1, BAD, FOXP3, RORγt and IFNλ3 as the host factors were investigated.MethodsThe study was conducted in ATLLs, HTLV-1-associated myelopat...
Salgaro, Massimo; Van Tourhout, Benjamin; 96772;
status: published
Foley, Jeannine Burnham, Veronica Tedoldi, Meghan Danial, Nika N Yellen, Gary
Published in
Epilepsia
Metabolic alteration, either through the ketogenic diet (KD) or by genetic alteration of the BAD protein, can produce seizure protection in acute chemoconvulsant models of epilepsy. To assess the seizure-protective role of knocking out (KO) the Bad gene in a chronic epilepsy model, we used the Kcna1-/- model of epilepsy, which displays progressivel...
