Onrust, Lonneke Baeyen, Steve Haesebrouck, Freddy Ducatelle, Richard Van Immerseel, Filip
Published in
Veterinary Research
Butyrate has been used extensively as a feed additive to improve gut health and to decrease Salmonella colonization in poultry. Salmonella mainly colonizes the ceca so butyrate concentrations should be increased in this gut segment. Discrepancies on the effects of butyrate on Salmonella colonization, described in the scientific literature, could th...
Yang, J. Kim, C.J. Go, Y.S. Lee, H.Y. Kim, M.-G. Oh, S.W. Cho, W.Y. Im, S.-H. Jo, S.K.
Intestinal microbiota impacts the host immune system and influences the outcomes of chronic diseases. However, it remains uncertain whether acute kidney injury (AKI) impacts intestinal microbiota or vice versa. To determine this, we investigated the mechanistic link between AKI, microbiota, and immune response in ischemia/reperfusion injury. Microb...
Keck, FD Polizzi, K
Advances in synthetic biology have made microbes easier to engineer than ever before. However, synthetic biology in animals and plants has lagged behind. Since it is now known that the phenotype of higher organisms depends largely on their microbiota, we propose that this is an easier route to achieving synthetic biology applications in these organ...
Hassan, Amir dos Santos, Sandra C. Cooper, Vaughn S. Sa-Correia, Isabel
During chronic respiratory infections of cystic fibrosis (CF) patients, bacteria adaptively evolve in response to the nutritional and immune environment as well as influence other infecting microbes. The present study was designed to gain insights into the genetic mechanisms underlying adaptation and diversification by the two most prevalent pathog...
Berbers, Bas Ceyssens, Pieter-Jan Bogaerts, Pierre Vanneste, Kevin Roosens, Nancy H. C. Marchal, Kathleen De Keersmaecker, Sigrid C. J.
Published in
Antibiotics
Antimicrobial resistance (AMR) is one of the most prominent public health threats. AMR genes localized on plasmids can be easily transferred between bacterial isolates by horizontal gene transfer, thereby contributing to the spread of AMR. Next-generation sequencing (NGS) technologies are ideal for the detection of AMR genes; however, reliable reco...
Wang, Shujun Zhang, Yongqiang Zhuo, Peng Hu, Qiushi Chen, Zhenqiang Zhou, Lei
The identification of pathogenic microorganisms is crucial to human health and industrial development, however, traditional culture-based methods are laborious and time consuming. We developed a novel method for the identification of pathogenic microorganisms based on single concentration-dependent carbon dots (CDs). The CDs were synthesized using ...
Wang, Shujun Zhang, Yongqiang Zhuo, Peng Hu, Qiushi Chen, Zhenqiang Zhou, Lei
The identification of pathogenic microorganisms is crucial to human health and industrial development, however, traditional culture-based methods are laborious and time consuming. We developed a novel method for the identification of pathogenic microorganisms based on single concentration-dependent carbon dots (CDs). The CDs were synthesized using ...
Marzorati, Massimo Van den Abbeele, Pieter Bubeck, Sarah S. Bayne, Thomas Krishnan, Kiran Young, Aicacia Mehta, Dilip DeSouza, Anselm
Published in
Microorganisms
Benefits associated with probiotic use have been reported; however, the mechanisms behind these benefits are poorly understood. The effects of a probiotic formulation (MegaDuo™) containing Bacillus coagulans SC208 and Bacillus subtilis HU58 on intestinal permeability and immune markers was assessed using a combination of the in vitro gut model, the...
Uvyn, Annemiek De Geest, Bruno
Antibody-recruiting molecules (ARMs) are a novel class of immunotherapeutics. They are capable of introducing antibodies onto disease-relevant targets such as cancer cells, bacterial cells or viruses. This can induce antibody-mediated immune responses such as antibody-dependent cellular cytotoxicity (ADCC), complement-dependent cytotoxicity (CDC) a...
Haldar, K George, L Wang, Z Mistry, V Ramsheh, MY Free, RC John, C Reeve, NF Miller, BE Tal-Singer, R
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Background Airway bacterial dysbiosis is a feature of chronic obstructive pulmonary disease (COPD). However, there is limited comparative data of the lung microbiome between healthy smokers, non-smokers and COPD. Methods We compared the 16S rRNA gene-based sputum microbiome generated from pair-ended Illumina sequencing of 124 healthy subjects (28 s...
