Romberg, Neil Le Coz, Carole Glauzy, Salomé Schickel, Jean-Nicolas Trofa, Melissa Nolan, Brian E. Paessler, Michele Xu, Mina LuQing Lambert, Michele Lakhani, Saquib A.
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Published in
The Journal of allergy and clinical immunology
Common variable immunodeficiency patients with autoimmune cytopenias exhibit hyperplastic germinal center reactions that fail to generate isotype-switched, somatically- mutated, immune-protective antibodies and instead produce poorly mutated, non-tolerized antibodies that recognize commensal bacteria and hematopoietic self-antigens.
Baranyi, Ulrike Farkas, Andreas M Hock, Karin Mahr, Benedikt Linhart, Birgit Gattringer, Martina Focke-Tejkl, Margit Petersen, Arnd Wrba, Fritz Rülicke, Thomas
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Published in
EBioMedicine
Therapeutic strategies for the prophylaxis of IgE-mediated allergy remain an unmet medical need. Cell therapy is an emerging approach with high potential for preventing and treating immunological diseases. We aimed to develop a cell-based therapy inducing permanent allergen-specific immunological tolerance for preventing IgE-mediated allergy. Wild-...
Jung, Sophie Schickel, Jean-Nicolas Kern, Aurélie Knapp, Anne-Marie Eftekhari, Pierre Da Silva, Sylvia Jaulhac, Benoît Brink, Robert Soulas-Sprauel, Pauline Pasquali, Jean-Louis
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Published in
European journal of immunology
The links between infections and the development of B-cell-mediated autoimmune diseases are still unclear. In particular, it has been suggested that infection-induced stimulation of innate immune sensors can engage low affinity autoreactive B lymphocytes to mature and produce mutated IgG pathogenic autoantibodies. To test this hypothesis, we establ...
Romberg, Neil Virdee, Manmeet Chamberlain, Nicolas Oe, Tyler Schickel, Jean-Nicolas Perkins, Tiffany Cantaert, Tineke Rachid, Rima Rosengren, Sally Palazzo, Regina
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Published in
The Journal of allergy and clinical immunology
Heterozygous C104R or A181E TNF receptor superfamily member 13b (TNFRSF13B) mutations impair removal of autoreactive B cells, weaken B-cell activation, and convey to patients with common variable immune deficiency (CVID) an increased risk for autoimmunity. How mutant transmembrane activator and CAML interactor (TACI) influences wild-type TACI funct...
Schaffert, Hanne Pelz, Andreas Saxena, Abhishek Losen, Mario Meisel, Andreas Thiel, Andreas Kohler, Siegfried
Published in
European journal of immunology
The role of Th17 cells in the pathogenesis of autoantibody-mediated diseases is unclear. Here, we assessed the contribution of Th17 cells to the pathogenesis of experimental autoimmune myasthenia gravis (EAMG), which is induced by repetitive immunizations with Torpedo californica acetylcholine receptor (tAChR). We show that a significant fraction o...
Dahal, Lekh N Cragg, Mark S
Published in
European journal of immunology
CD20-based monoclonal antibodies have become established as treatments for lymphoma, rheumatoid arthritis, systemic lupus erythematosus, vasculitis and dermatomyositis, with the principle therapeutic mechanism relating to B-cell depletion through effector cell engagement. An article by Brühl et al. in this issue of the European Journal of Immunolog...
Hobeika, Elias Nielsen, Peter J. Medgyesi, David
Published in
Journal of Molecular Medicine
It is becoming more and more accepted that, in addition to producing autoantibodies, B lymphocytes have other important functions that influence the development of autoimmunity. For example, autoreactive B cells are able to produce inflammatory cytokines and activate pathogenic T cells. B lymphocytes can react to extracellular signals with a range ...
Navarro Alvarez, Nalu Zhu, Alexander Arellano, Ronald S Randolph, Mark A Duggan, Michael Scott Arn, John Huang, Christene A Sachs, David H Vagefi, Parsia A
Published in
Xenotransplantation
In summary, xenogeneic B-cell tolerance was induced through in utero intraportal exposure to donor cells and this tolerance persisted following postnatal rechallenge with donor B-BM, but was lost on exposure to third-party antigen, possibly as a result of cross-reactive antibody formation.
Menard, Laurence Cantaert, Tineke Chamberlain, Nicolas Tangye, Stuart G Riminton, Sean Church, Joseph A Klion, Amy Cunningham-Rundles, Charlotte Nichols, Kim E Meffre, Eric
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Published in
The Journal of allergy and clinical immunology
Signaling lymphocytic activation molecule (SLAM)-associated protein (SAP) can mediate the function of SLAM molecules, which have been proposed to be involved in the development of autoimmunity in mice. We sought to determine whether the SLAM/SAP pathway regulates the establishment of human B-cell tolerance and what mechanisms of B-cell tolerance co...
Baranyi, Ulrike Gattringer, Martina Farkas, Andreas M Hock, Karin Pilat, Nina Iacomini, John Valenta, Rudolf Wekerle, Thomas
Published in
European journal of immunology
The transplantation of allergens (e.g. Phl p 5 or Bet v 1) expressed on BM cells as membrane-anchored full-length proteins leads to permanent tolerance at the T-cell, B-cell, and effector-cell levels. Since the exposure of complete allergens bears the risk of inducing anaphylaxis, we investigated here whether expression of Phl p 5 in the cytoplasm ...
