Pistollato, Francesca Forbes-Hernandez, Tamara Yuliett Iglesias, Ruben Calderón Ruiz, Roberto Elexpuru Zabaleta, Maria Dominguez, Irma Cianciosi, Danila Quiles, Josè L Giampieri, Francesca Battino, Maurizio
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Published in
Seminars in cancer biology
Fasting, caloric restriction and foods or compounds mimicking the biological effects of caloric restriction, known as caloric restriction mimetics, have been associated with a lower risk of age-related diseases, including cardiovascular diseases, cancer and cognitive decline, and a longer lifespan. Reduced calorie intake has been shown to stimulate...
Varela-López, Alfonso Vera-Ramírez, Laura Giampieri, Francesca Navarro-Hortal, María D Forbes-Hernández, Tamara Y Battino, Maurizio Quiles, José L
Published in
Seminars in cancer biology
Evidence demonstrates the importance of lipid metabolism and signaling in cancer cell biology. De novo lipogenesis is an important source of lipids for cancer cells, but exogenous lipid uptake remains essential for many cancer cells. Dietary lipids can modify lipids present in tumor microenvironment affecting cancer cell metabolism. Clinical trials...
Ji, Qijian Sun, Zhaorui Yang, Zhizhou Zhang, Wei Ren, Yi Chen, Weijun Yao, Mengya Nie, Shinan
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Molecular immunology
Sepsis-induced acute lung injury (ALI) is a life-threatening medical condition with high mortality and morbidity in the critical care units. Though, it was commonly accepted that inflammation and apoptosis of lung epithelial cells played an essential role in the pathogenesis of ALI, the underlying mechanism remain unknown. In our study, we found th...
Pei, Xiao-Dong He, Zhi-Long Yao, Hong-Liang Xiao, Jun-Song Li, Lan Gu, Jian-Zhong Shi, Pei-Zhao Wang, Jin-Hua Jiang, Li-He
Published in
European journal of nutrition
6-Shogaol, an active phenolic compound from ginger (Zingiber officinale), can inhibit the growth of a variety of human cancer cells. Nevertheless, its underlying molecular mechanisms in cervical cancer remain unclear. In this study, we systematically examine the inhibitory effect of 6-shogaol on cervical cancer in vitro and in vivo. Cell proliferat...
Gao, Shan Tang, Yi-Yun Jiang, Li Lan, Fang Li, Xiang Zhang, Ping Zou, Wei Chen, Yong-Jun Tang, Xiao-Qing
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Neurochemical research
Sleep deprivation (SD) is widespread in society causing serious damage to cognitive function. Hydrogen sulfide (H2S), the third gas signal molecule, plays important regulatory role in learning and memory functions. Inhibition of excessive autophagy and upregulation of silent information regulator 1 (Sirt-1) have been reported to prevent cognitive d...
Liu, Bing Zhou, Han Zhang, Tiening Gao, Xixiang Tao, Bo Xing, Hao Zhuang, Zhenwu Dardik, Alan Kyriakides, Themis R Goodwin, Julie E
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Angiogenesis
The glucocorticoid receptor (GR) is a member of the nuclear receptor family that controls key biological processes in the cardiovascular system and has recently been shown to modulate Wnt signaling in endothelial cells. Wnt/β-catenin signaling has been demonstrated to be crucial in the process of angiogenesis. In the current study, we studied wheth...
Zhang, Jia-Qing Ren, Qiao-Ling Chen, Jun-Feng Gao, Bin-Wen Wang, Xian-Wei Zhang, Zi-Jing Wang, Jing Xu, Ze-Jun Xing, Bao-Song
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Reproductive sciences (Thousand Oaks, Calif.)
Oxidative stress-induced granulosa cell (GC) death is a major cause of follicular atresia. As the major types of programmed cell death, autophagy and apoptosis have been observed in response to H2O2-mediated oxidative stress and have been demonstrated to be responsible for porcine GC death. To date, however, the cellular reactions linking autophagy...
Sumkhemthong, Somruethai Prompetchara, Eakachai Chanvorachote, Pithi Chaotham, Chatchai
Published in
Biological Research
BackgroundAccumulated evidence demonstrates cisplatin, a recommended chemotherapy, modulating pro-survival autophagic response that contributes to treatment failure in lung cancer patients. However, distinct mechanisms involved in cisplatin-induced autophagy in human lung cancer cells are still unclear.ResultsHerein, role of autophagy in cisplatin ...
Wang, Fangfei He, Quan Gao, Zhiqian Redington, Andrew N.
Published in
Basic Research in Cardiology
Altered autophagy is implicated in several human cardiovascular diseases. Remote ischemic conditioning (RIC) is cardioprotective in multiple cardiovascular injury models and modifies autophagy signaling, but its effect in cardiomyopathy induced by gene manipulation has not been reported. To investigate the cardiac effects of chronically reduced aut...
Nabar, Neel R Heijjer, Christopher N Shi, Chong-Shan Hwang, Il-Young Ganesan, Sundar Karlsson, Mikael C I Kehrl, John H
Published in
Autophagy
CD38 is a cell surface receptor capable of generating calcium-mobilizing second messengers. It has been implicated in host defense and cancer biology, but signaling mechanisms downstream of CD38 remain unclear. Mutations in LRRK2 (leucine-rich repeat kinase 2) are the most common genetic cause of Parkinson disease; it is also a risk factor for Croh...
