Zhang, Xinxin Qin, Yating Wan, Xiaoning Liu, Hao Lv, Chao Ruan, Weibin He, Lin Lu, Li Guo, Xiaomei
Published in
Journal of Translational Medicine
BackgroundAtherosclerosis is a chronic vascular disease posing a great threat to public health. We investigated whether rosuvastatin (RVS) enhanced autophagic activities to inhibit lipid accumulation and polarization conversion of macrophages and then attenuate atherosclerotic lesions.MethodsAll male Apolipoprotein E-deficient (ApoE−/−) mice were f...
Yuan, Hui Lu, Jun
Published in
BMC Genomics
BackgroundDespite several RNA-Seq and microarray studies on differentially expressed genes (DEGs) between high- and low-abdominal fat deposition in different broiler lines, to our knowledge, gene coexpression analysis across multiple broiler lines has rarely been reported. Here, we constructed a consensus gene coexpression network focused on identi...
Chen, Hui-Yong Xiao, Ze-Zhou Ling, Xiao Xu, Rong-Ning Zhu, Peng Zheng, Shao-Yi
Published in
Molecular Medicine
AimsMyocardial ischemia is the most common form of cardiovascular disease and the leading cause of morbidity and mortality. Understanding the mechanisms is very crucial for the development of effective therapy. Therefore, this study aimed to investigate the functional roles and mechanisms by which ELAVL1 regulates myocardial ischemia and reperfusio...
Lu, Qingchun Wang, Po-Shun Yang, Ling
Published in
Cell & Bioscience
Autophagy is a conserved cellular degradation process in eukaryotes that facilitates the recycling and reutilization of damaged organelles and compartments. It plays a pivotal role in cellular homeostasis, pathophysiological processes, and diverse diseases in humans. Autophagy involves dynamic crosstalk between different stages associated with intr...
Hiraga, Chiho Yamamoto, Satoshi Hashimoto, Sadamitsu Kasahara, Masataka Minamisawa, Tamiko Matsumura, Sachiko Katakura, Akira Yajima, Yasutomo Nomura, Takeshi Shiba, Kiyotaka
...
Published in
Scientific Reports
Oral fluids (OFs) contain small extracellular vesicles (sEVs or exosomes) that carry disease-associated diagnostic molecules. However, cells generate extracellular vesicles (EVs) other than sEVs, so the EV population is quite heterogeneous. Furthermore, molecules not packaged in EVs can also serve as diagnostic markers. For these reasons, developin...
Huang, Chong Chen, Yan Lai, Bin Chen, Yan-Xia Xu, Cheng-Yun Liu, Yuan-Fei
Published in
Journal of Inflammation
BackgroundAcute kidney injury (AKI) is a major kidney disease with poor clinical outcome. SP1, a well-known transcription factor, plays a critical role in AKI and subsequent kidney repair through the regulation of various cell biologic processes. However, the underlying mechanism of SP1 in these pathological processes remain largely unknown.Methods...
Zhang, Fengyun Gao, Fei Wang, Kun Liu, Xiaohong Zhang, Zhuoqi
Published in
Stem Cell Research & Therapy
BackgroundMesenchymal stem cells (MSCs) are favourable treatments for ischaemic diseases; however, MSCs from diabetic patients are not useful for this purpose. Recent studies have shown that the expression of miR-34a is significantly increased in patients with hyperglycaemia; the precise role of miR-34a in MSCs in diabetes needs to be clarified.Obj...
Pal, Asmita Verma, Preeti Paul, Subhabrata Majumder, Indira Kundu, Rita
Published in
3 Biotech
Edible green algal seaweeds, namely Ulva intestinalis and Ulva lactuca constitute a significant repository of popular herbal medicines in the Traditional Chinese Medicinal system. The present study aimed to assess the anticancer potential of these algal members and its mode of action in cervical cancer cells SiHa. The algal samples primarily extrac...
Zhou, Yu Lu, Long-Feng Zhang, Can Chen, Dan-Dan Zhou, Xiao-Yu Li, Zhuo-Cong Jiang, Jing-Yu Li, Shun Zhang, Yong-An
Published in
Developmental and comparative immunology
In mammals, cyclic GMP-AMP synthase (cGAS) is a crucial cytosolic DNA sensor responsible for activating the interferon (IFN) response. A cGAS-like (cGASL) gene was previously identified from grass carp Ctenopharyngodon idellus, which is evolutionarily closest to cGAS but not a true ortholog of cGAS. Here, we found that grass carp cGASL targets mito...
Meng, Qinghai Li, Yu Ji, Tingting Chao, Ying Li, Jun Fu, Yu Wang, Suyun Chen, Qi Chen, Wen Huang, Fuhua
...
Published in
Journal of advanced research
Excessive inflammation and the pyroptosis of vascular endothelial cells caused by estrogen deficiency is one cause of atherosclerosis in post-menopausal women. Because autophagy is highly regulated by estrogen, we hypothesized that estrogen can reduce vascular endothelial cell pyroptosis through estrogen receptor alpha (ERα)-mediated activation of ...
