Alexander-Floyd, J. Haroon, S. Ying, M. Entezari, A. A. Jaeger, C. Vermulst, M. Gidalevitz, T.
Published in
BMC Biology
BackgroundMonogenic protein aggregation diseases, in addition to cell selectivity, exhibit clinical variation in the age of onset and progression, driven in part by inter-individual genetic variation. While natural genetic variants may pinpoint plastic networks amenable to intervention, the mechanisms by which they impact individual susceptibility ...
Xia, Qingquan Wu, Xuhua Rong, Ke Zhou, Zhenyu Li, Xujun Fei, Teng Yin, Xiaofan
Published in
Journal of Orthopaedic Surgery and Research
BackgroundTo study the role of lysosomal decomposition and elimination of old bone matrix, as well as the mechanism of promoting chondrocyte growth and bone recovery through the perspective of TFEB-mediated lysosomal autophagy.MethodsRat models of acute knee injury were designed, and autophagy flow was detected by injection of autophagy inhibitors ...
Elmatboly, Abdelmagid M. Sherif, Ahmed M. Deeb, Dalia A. Benmelouka, Amira Bin-Jumah, May N. Aleya, Lotfi Abdel-Daim, Mohamed M.
Aggregation of particular proteins in the form of inclusion bodies or plaques followed by neuronal death is a hallmark of neurodegenerative proteopathies such as primary Parkinsonism, Alzheimer’s disease, Lou Gehrig’s disease, and Huntington’s chorea. Complex polygenic and environmental factors implicated in these proteopathies. Accumulation of pro...
Tian, Feng Wang, Junhu Zhang, Zhanhua Yang, Jie
Published in
Biological Research
BackgroundOsteoarthritis (OA) is one of the most common rheumatic diseases of which clinical symptoms includes swelling, synovitis and inflammatory pain, affect patients’ daily life. It was reported that non-coding RNAs play vital roles in OA. However, the regulation mechanism of ncRNA in OA pathogenesis has not been fully elucidated.MethodsThe exp...
Yuan, Jian-Qi Yuan, Yang Pan, Shan-Shan Cai, Ke
Published in
The Journal of Physiological Sciences
Exercise has been reported to induce autophagy. We hypothesized that exercise preconditioning (EP)-related autophagy in cardiomyocytes could be attributed to intermittent ischemia–hypoxia, allowing the heart to be protected for subsequent high-intensity exercise (HE). We applied approaches, chromotrope-2R brilliant green (C-2R BG) staining and plas...
Ham, Sung Yeon Nam, Sang Beom Kwak, Young-Lan Kim, Tae Lim Park, Jong-Kwang Shim, Yon Hee
Published in
The journals of gerontology. Series A, Biological sciences and medical sciences
Age and acute hyperglycemia are known risk factors of myocardial ischemia-reperfusion injury. We investigated age-related difference in the effect of acute hyperglycemia on myocardial ischemia-reperfusion injury in Sprague-Dawley rats (young, 3 months; middle-aged, 10-12 months; and old, 22-24 months). The rats received 1.2 g/kg dextrose or normal ...
van Niekerk, Gustav Meaker, Charné Engelbrecht, Anna-Mart
Published in
Critical Care
Despite sound basis to suspect that aggressive and early administration of nutritional support may hold therapeutic benefits during sepsis, recommendations for nutritional support have been somewhat underwhelming. Current guidelines (ESPEN and ASPEN) recognise a lack of clear evidence demonstrating the beneficial effect of nutritional support durin...
Khan, Anzer Paro, Simona McGurk, Leeanne Sambrani, Nagraj Hogg, Marion C. Brindle, James Pennetta, Giuseppa Keegan, Liam P. O’Connell, Mary A.
Published in
BMC Biology
BackgroundIn fly brains, the Drosophila Adar (adenosine deaminase acting on RNA) enzyme edits hundreds of transcripts to generate edited isoforms of encoded proteins. Nearly all editing events are absent or less efficient in larvae but increase at metamorphosis; the larger number and higher levels of editing suggest editing is most required when th...
Yang, Zhengming Yu, Wei Liu, Bing Yang, Minfei Tao, Huimin
Published in
Journal of Orthopaedic Surgery and Research
BackgroundEstrogen receptor beta (ERβ) was considered as a tumor-inhibiting factor in estrogen-sensitive malignant tumors. In this study, we intended to investigate whether ERβ was involved in inducing autophagy in osteosarcoma.MethodsThis is an experimental study. The associations between ERβ and autophagy were detected in osteosarcoma U2-OS cells...
Hassanpour, Mehdi Hajihassani, Fateme Hiradfar, Amirataollah Aghamohammadzadeh, Nasser Rahbarghazi, Reza Safaie, Nasser Nouri, Mohammad Panahi, Yunes
Published in
Journal of Inflammation
The occurrence of neurodegenerative disease is increasingly raised. From physiopathological aspect, the emergence of auto-reactive antibodies against the nervous system antigens contributes to de-myelination in Multiple sclerosis (MS). These features cause the nervous system dysfunction. The follow-up of molecular alterations could give us a real-s...
