Romero-Santos, Sofia Parra-Tanoux, Daniela Cifuentes-González, Carlos Muñoz-Ortiz, Juliana Mejía-Salgado, Germán de-la-Torre, Alejandra
Published in
Ocular immunology and inflammation
To present an atypical case of severe bilateral ocular toxoplasmosis with systemic involvement that initially mimicked an autoimmune etiology, posing challenges to its diagnosis and treatment. A 39-year-old immunocompetent male was admitted to the hospital due to a presumed pulmonary thromboembolism concomitant with an abrupt onset of vision loss. ...
Braun, Jürgen Märker-Hermann, Elisabeth Rudwaleit, Martin Sieper, Joachim
Published in
Annals of the rheumatic diseases
Boukouaci, Wahid Lajnef, Mohamed Wu, Ching-Lien Bouassida, Jihène Saitoh, Kaori Sugunasabesan, Sobika Richard, Jean-Romain Apavou, Maud Lamy, Anais Henensal, Adèle
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Immune dysregulation is an important aspect of schizophrenia (SZ) and bipolar disorders (BD) pathophysiology, including not only inflammatory but also autoimmune process reflective of abnormal humoral immune responses. Given that B cell-activating factor (BAFF) is an integral aspect of B lymphocyte regulation, the current study investigated BAFF in...
Hooda, Vishakha Khandpur, Sujay Arava, Sudheer Sharma, Alpana
Published in
Immunology letters
Pemphigus vulgaris (PV) is a rare autoimmune disorder where autoantibodies target the desmosomal proteins resulting in blistering of oral mucosa and skin. While the pathogenesis of PV is mainly mediated by the adaptive immune system, key players of innate immunity are also emerging. This study outlines the phenotypic as well as functional attribute...
Ronca, Vincenzo Gerussi, Alessio Collins, Paul Parente, Alessandro Oo, Ye Htun Invernizzi, Pietro
Published in
Physiological reviews
The purpose of this review is to describe the immune function of the liver, guiding the reader from the homeostatic tolerogenic status to the aberrant activation demonstrated in chronic liver disease. An extensive description of the pathways behind the inflammatory modulation of the healthy liver will be provided focusing on the complex immune cell...
Dolton, Garry Bulek, Anna Wall, Aaron Thomas, Hannah Hopkins, Jade R Rius, Cristina Galloway, Sarah Ae Whalley, Thomas Tan, Li Rong Morin, Théo
...
Published in
The Journal of clinical investigation
CD8+ T cells destroy insulin-producing pancreatic β cells in type 1 diabetes through HLA class I-restricted presentation of self-antigens. Combinatorial peptide library screening was used to produce a preferred peptide recognition landscape for a patient-derived T cell receptor (TCR) that recognized the preproinsulin-derived (PPI-derived) peptide s...
Moseley, Carson E Virupakshaiah, Akash Forsthuber, Thomas G Steinman, Lawrence Waubant, Emmanuelle Zamvil, Scott S
At one time considered a possible form of neuromyelitis optica (NMO) spectrum disorder (NMOSD), it is now accepted that myelin oligodendrocyte glycoprotein (MOG) antibody (Ab)-associated disorder (MOGAD) is a distinct entity from either NMO or multiple sclerosis (MS) and represents a broad spectrum of clinical phenotypes. Whereas Abs targeting aqua...
Bourel, Louisa Bray, Fabrice Vivier, Solange Flament, Stephanie Guilbert, Lucile Chepy, Aurelien Rolando, Christian Launay, David Dubucquoi, Sylvain Sobanski, Vincent
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Immunoglobulin G (IgG) purification is a critical process for evaluating its role in autoimmune diseases, which are defined by the occurrence of autoantibodies. Affinity chromatography with protein G is widely considered to be the optimal technique for laboratory-scale purification. However, this technique has some limitations, including the exposu...
Groegler, Jason Callebaut, Aïsha James, Eddie A Delong, Thomas
Published in
Diabetologia
In type 1 diabetes, the insulin-producing beta cells of the pancreas are destroyed through the activity of autoreactive T cells. In addition to strong and well-documented HLA class II risk haplotypes, type 1 diabetes is associated with noncoding polymorphisms within the insulin gene locus. Furthermore, autoantibody prevalence data and murine studie...
Elhani, I Aouba, A Riller, Q Vergneault, H Boursier, G Rieux-Laucat, F Hentgen, V Georgin-Lavialle, S
Published in
La Revue de medecine interne
A20 Haploinsufficiency (HA20) is a monogenic autoinflammatory disease associated with an autosomal dominant mutation in the TNFAIP3 gene. It induces a defect in the inactivation of the pro-inflammatory NF-κB pathway. Less than 200 cases have been described worldwide. The clinical picture of the disease is essentially based on the association of rec...