Autoimmune disorders and venous thromboembolism: An update from the COMMAND VTE registry.
Published in European journal of internal medicine
Classical Human Leukocyte Antigen Alleles and C4 Haplotypes Are Not Significantly Associated With Depression.
...Published in Biological psychiatry
The prevalence of depression is higher in individuals with autoimmune diseases, but the mechanisms underlying the observed comorbidities are unknown. Shared genetic etiology is a plausible explanation for the overlap, and in this study we tested whether genetic variation in the major histocompatibility complex (MHC), which is associated with risk f...
Classical human leukocyte antigen alleles and C4 haplotypes are not significantly associated with depression
...
Background : The prevalence of depression is higher in individuals with autoimmune diseases, but the mechanisms underlying the observed comorbidities are unknown. Shared genetic etiology is a plausible explanation for the overlap, and in this study we tested whether genetic variation in the major histocompatibility complex (MHC), which is associate...
Structural and Mechanistic Insights of CRAC Channel as a Drug Target in Autoimmune Disorder.
Published in Current drug targets
Calcium (Ca2+) ion is a major intracellular signaling messenger, controlling a diverse array of cellular functions like gene expression, secretion, cell growth, proliferation, and apoptosis. The major mechanism controlling this Ca2+ homeostasis is store-operated Ca2+ release-activated Ca2+ (CRAC) channels. CRAC channels are integral membrane protei...
Connective Tissue Disorders in Patients With Thrombotic Thrombocytopenic Purpura: A Retrospective Analysis Using a Natio...
Published in Journal of clinical medicine research
Prior reports have shown acquired thrombotic thrombocytopenic purpura (TTP) co-existing with connective tissue disorders (CTD). However, these are mainly limited to case reports and case-series reports, and the patient characteristics and clinical outcomes in these patients are not well known. We used National Inpatient Sample and Nationwide Inpati...
cGAS activation causes lupus-like autoimmune disorders in a TREX1 mutant mouse model.
Published in Journal of autoimmunity
TREX1 encodes a major cellular DNA exonuclease. Mutations of this gene in human cause cellular accumulation of DNA that triggers autoimmune diseases including Aicardi-Goutieres Syndrome (AGS) and systemic lupus erythematosus (SLE). We created a lupus mouse model by engineering a D18 N mutation in the Trex1 gene which inactivates the enzyme and has ...
Crohn’s disease in a developing African mission hospital: a case report
Published in Journal of Medical Case Reports
BackgroundA case is reported of innocuous intestinal obstruction requiring surgical intervention that was confirmed to be Crohn’s disease histopathologically in a resource-constrained rural mission hospital in Cameroon.Case presentationA 70-year man of Kumbo origin from Northwest region of Cameroon with a history of crampy right lower-quadrant abdo...
PANDAS versus Hashimoto`s encephalopathy: a diagnostic dilemma in a Saudi girl
Published in Sudanese Journal of Paediatrics
Paediatric autoimmune neuropsychiatric disorders associated with streptococcal infections (PANDAS) is a rare recently recognised clinical syndrome with common presentations that include tics, Tourette’s-like syndrome or obsessive-compulsive disorder. It is associated with various behavioural and psychiatric manifestations in children, such as separ...
Autoimmune disorders but not heparin are associated with cell-free fetal DNA test failure
Published in Journal of Translational Medicine
BackgroundRecent studies have suggested a possible association between heparin treatment at the time of cell-free DNA (cfDNA) testing and a non-reportable result. However, these studies lack of proper methodology and had a low level of proof to firmly incriminate heparin. Our objective was to investigate further the relationship between heparin tre...
Identification of non-HLA genes associated with development of islet autoimmunity and type 1 diabetes in the prospective...
...Published in Journal of autoimmunity
Traditional linkage analysis and genome-wide association studies have identified HLA and a number of non-HLA genes as genetic factors for islet autoimmunity (IA) and type 1 diabetes (T1D). However, the relative risk associated with previously identified non-HLA genes is usually very small as measured in cases/controls from mixed populations. Geneti...
