Published in BMC Research Notes
ObjectiveAutism spectrum disorder (ASD) encompasses a group of neurodevelopmental conditions that remain poorly understood due to their genetic complexity. CHD8 is a risk allele strongly associated with ASD, and heterozygous Chd8 loss-of-function mice have been reported to exhibit macrocephaly in early postnatal stages. In this work, we sought to i...
Published in BMC Psychiatry
BackgroundThe Autism Diagnostic Observation Schedule, Second Edition (ADOS-2) module four assessment for diagnosing autism spectrum disorder in adults has shown good sensitivity and specificity in research settings.MethodThis study aimed to evaluate the predictive accuracy of the ADOS-2 module four by investigating the components of the assessment,...
Published in Clinical Epigenetics
BackgroundAutism spectrum disorder (ASD) has increased over tenfold over the past several decades and appears predominantly associated with paternal transmission. Although genetics is anticipated to be a component of ASD etiology, environmental epigenetics is now also thought to be an important factor. Epigenetic alterations, such as DNA methylatio...
Published in Journal of Neurodevelopmental Disorders
BackgroundAdults and adolescents with autism spectrum disorders show greater difficulties comprehending speech in the presence of noise. Moreover, while neurotypical adults use visual cues on the mouth to help them understand speech in background noise, differences in attention to human faces in autism may affect use of these visual cues. No work h...
Published in Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics
There are multiple disorders of neurodevelopment that present with co-occurring sleep disturbances. Many of these neurodevelopmental disorders (NDD) include sleep disturbances in their diagnostic criteria. Neurobiological, genetic, and environmental factors overlap to cause different sleep disorders in individuals with NDD. Caregivers often present...
Research on emergent autism spectrum disorder increasingly uses observational measures to investigate parenting of young children with or at elevated likelihood of autism. This systematic review analysed 21 papers narratively, including 13 unique 'coding approaches' and 63 parenting constructs. Through a comprehensive consensus decision-making proc...
Published in The American journal of psychiatry
Certain copy number variants (CNVs) greatly increase the risk of autism. The authors conducted a genetics-first study to investigate whether heterogeneity in the clinical presentation of autism is underpinned by specific genotype-phenotype relationships. This international study included 547 individuals (mean age, 12.3 years [SD=4.2], 54% male) who...
Little ethical recommendations on returning children's individual research findings are available for researchers in behavioral sciences, especially when compared to genetic research. Anecdotic evidence suggests that since parents are often interested in their child's individual research findings, researchers tend to offer this information as a for...
Studien syftar till att bidra med ökad förståelse om musiklärares arbete med elever med NPF (neuropsykiatrisk funktionsnedsättning) i den ordinarie undervisningen. Jag har sökt finna både musiklärares arbetssätt och uppfattningar kring elever med NPF. Studien utgår från ett relationellt perspektiv. Jag har genomfört fyra kvalitativa intervjuer med ...
Published in International immunopharmacology
Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder which manifests itself in early childhood and is distinguished by recurring behavioral patterns, and dysfunction in social/communication skills. Ubiquitous environmental pollutant, di-2-ethylhexyl phthalate (DEHP) is one of the most frequently used plasticizers in various indus...
