Wei, Zhenheng Ran, Huazhong Yang, Chunhua
Published in
Life sciences
Compelling evidences demonstrate that informative RNAs play essential role in therapy of atherosclerosis. Here, we attempted to study the role of hsa_circ_0000345 (circRSF1) in endothelial cell damage through competing endogenous RNA pathway. Expression of circRSF1, miRNA-758-3p (miR-758) and cyclin D2 (CCND2) was detected using RT-qPCR and western...
Musetti, Bruno González-Ramos, Helena González, Mercedes Bahnson, Edward M. Varela, Javier Thomson, Leonor
Published in
Journal of Cannabis Research
BackgroundMultiple therapeutic properties have been attributed to Cannabis sativa. However, further research is required to unveil the medicinal potential of Cannabis and the relationship between biological activity and chemical profile.ObjectivesThe primary objective of this study was to characterize the chemical profile and antioxidant properties...
Huang, Zhen Li, Penglei Wu, Leiming Zhang, Dianhong Du, Binbin Liang, Cui Gao, Lu Zhang, Yanzhou Yao, Rui
Published in
Life sciences
Circular RNAs (circRNAs) are relevant to atherosclerosis progression. However, the role and mechanism of circRNA hsa_circ_0029589 (circ_0029589) in atherosclerosis are not fully understood. This research aims to explore the function and mechanism of circ_0029589 in oxidized low-density lipoprotein (ox-LDL)-caused vascular smooth muscle cells (VSMCs...
Melin, Eva O. Dereke, Jonatan Hillman, Magnus
Published in
Lipids in Health and Disease
BackgroundThe receptors for advanced glycation end products (RAGE) are increased in atherosclerotic plaques. Soluble (s)RAGE decreases, whereas the extracellular newly identified receptor for advanced glycation end products (EN-RAGE) increases inflammatory responses mediated by RAGE. The aims were to explore whether sRAGE, EN-RAGE and the EN-RAGE/s...
Sterpetti, Antonio V
Published in
Current Atherosclerosis Reports
Purpose of the ReviewInflammatory cytokines play a major role in atherosclerotic plaque progression. This review summarizes the rationale for personalized anti-inflammatory therapy.Recent FindingsSystemic inflammatory parameters may be used to follow the clinical outcome in primary and secondary prevention. Medical therapy, both in patients with st...
Liu, Yi Cui, Xiyun Wang, Cong Zhao, Sihai
Published in
Biological Research
BackgroundAtherosclerosis (AS) is the main pathological basis of coronary heart disease, cerebral infarction and peripheral vascular disease, which seriously endanger people’s life and health. In recent years, long non-coding RNA (lncRNA) has been found to be involved in gene expression regulation, but the research on AS is still in the initial sta...
Ma, Ru Qi, Yi Zhao, Xinying Li, Xueyan Sun, Xuejing Niu, Piye Li, Yanbo Guo, Caixia Chen, Rui Sun, Zhiwei
...
Published in
Particle and Fibre Toxicology
BackgroundThe biosafety concern of silica nanoparticles (SiNPs) is rapidly expanding alongside with its mass production and extensive applications. The cardiovascular effects of SiNPs exposure have been gradually confirmed, however, the interaction between SiNPs exposure and atherosclerosis, and the underlying mechanisms still remain unknown. There...
Costa, Fernando Augusto Alves da
Jiao, Yungen Qin, Yahong Zhang, Zhengang Zhang, Hao Liu, Haiwei Li, Chen
Published in
BMC Cardiovascular Disorders
BackgroundThis study was to explore the influencing factors of atherosclerotic plaque formation and stability in patients with asymptomatic carotid atherosclerotic plaques, so as to identify the vulnerable plaques at early stage, and then find high-risk group of cardio-cerebrovascular events for early clinical intervention to reduce related mortali...
Mendieta, Jessica Benitez Fontanarosa, Davide Wang, Jiaqiu Paritala, Phani Kumari McGahan, Tim Lloyd, Thomas Li, Zhiyong
Published in
Biomechanics and modeling in mechanobiology
The initiation and progression of atherosclerosis, which is the main cause of cardiovascular diseases, correlate with local haemodynamic factors such as wall shear stress (WSS). Numerical simulations such as computational fluid dynamics (CFD) based on medical imaging have been employed to analyse blood flow in different arteries with and without lu...
