Beddhu, Srinivasan Boucher, Robert E. Sun, Jie Balu, Niranjan Chonchol, Michel Navaneethan, Sankar Chertow, Glenn M. Townsend, Raymond Haley, William Cheung, Alfred K.
...
Published in
BMC Nephrology
Background It is unclear whether faster progression of atherosclerosis explains the higher risk of cardiovascular events in CKD. The objectives of this study were to 1. Characterize the associations of CKD with presence and morphology of atherosclerotic plaques on carotid magnetic resonance imaging (MRI) and 2. Examine the associations of baseline ...
Burger, Fabienne Miteva, Kapka Baptista, Daniela Roth, Aline Fraga-Silva, Rodrigo A Martel, Catherine Stergiopulos, Nikolaos Mach, François Brandt, Karim J
Published in
Cardiovascular research
B cell functions in the process of atherogenesis have been investigated but several aspects remain to be clarified. In this study, we show that follicular regulatory helper T cells (TFR) control regulatory B cell (BREG) populations in Apoe-/- mice models on a high-cholesterol diet (HCD). Feeding mice with HCD resulted in up-regulation of TFR and BR...
Li, Man Duan, Lei Cai, Yulun Hao, Benchuan Chen, Jianqiao Li, Huiying Liu, Hongbin
Published in
Cardiovascular Diabetology
Background Soluble suppression of tumorigenesis-2 (sST2) is implicated in myocardial overload and has long been recognized as an inflammatory marker related to heart failure and acute coronary syndrome, but data on the prognostic value of sST2 in patients with coronary artery disease (CAD) remain limited. This study sought to investigate the progno...
Abriz, Aysan Eslami Rahbarghazi, Reza Nourazarian, Alireza Avci, Çıgır Biray Mahboob, Soltan Ali Rahnema, Maryam Araghi, Atefeh Heidarzadeh, Morteza
Published in
Journal of Inflammation (London, England)
Background Atherosclerosis is touted as one of the most critical consequences of diabetes mellitus indicated by local inflammation of endothelial cells. The Effect of Omega 3 fatty acids, mainly docosahexaenoic acid (DHA), has been investigated in cells after exposure to high doses of lipids. The current experiment aimed to address the modulatory e...
Kayikcioglu, Meral
Published in
Current Atherosclerosis Reports
Purpose of Review Lipoprotein apheresis is the most effective means of lipid-lowering therapy. However, it’s a semi-invasive, time consuming, and chronic therapy with variable adherence. There are still no specific guideline recommendations for the management of patients on lipid apheresis. The purpose of this review is to discuss the clinical indi...
Brampton, Christopher Pomozi, Viola Chen, Li-Hsieh Apana, Ailea McCurdy, Sara Zoll, Janna Boisvert, William A. Lambert, Gilles Henrion, Daniel Blanchard, Simon
...
Published in
Scientific Reports
ABCC6 deficiency promotes ectopic calcification; however, circumstantial evidence suggested that ABCC6 may also influence atherosclerosis. The present study addressed the role of ABCC6 in atherosclerosis using Ldlr −/− mice and pseudoxanthoma elasticum (PXE) patients. Mice lacking the Abcc6 and Ldlr genes were fed an atherogenic diet for 16 weeks b...
Abel, Dori Ardoin, Stacy P. Gorelik, Mark
Published in
Pediatric Rheumatology Online Journal
Background Patients with systemic lupus erythematous have a significantly increased risk of cardiovascular disease, which is not fully explained by traditional cardiovascular disease risk factors. Despite increasing life expectancy in patients with systemic lupus erythematous, mortality due to cardiovascular disease, the major cause of death in the...
Elfghi, M. Jordan, F. Dunne, D. Gibson, I. Jones, J. Flaherty, G. Sultan, S. Tawfick, W.
Published in
Trials
Background Peripheral arterial disease (PAD) affects more than 200 million of the global population. PAD represents a marker for premature cardiovascular events. Patients with PAD, even in the absence of a history of myocardial infarction or ischemic stroke, have approximately the same relative risk of death from cardiovascular causes as patients w...
Zhao, Ruifeng Xiao, Hanyan Jin, Tao Xu, Feng Li, Yan Li, Haiyan Zhang, Zhouyi Zhang, Yan
Published in
Brazilian Journal of Medical and Biological Research
Naringenin (NAR) is a major flavanone in citrus fruits that has multiple pharmacological attributes such as anticancer and antiatherogenic. This study aims to investigate the mechanism of NAR in high-fat-diet (HFD)-induced atherosclerosis (AS) in apolipoprotein E-knockout (ApoE-/-) mice. A HFD-induced AS ApoE-/- mouse model was established. The mic...
Zhang, Xinxin Qin, Yating Wan, Xiaoning Liu, Hao Lv, Chao Ruan, Weibin He, Lin Lu, Li Guo, Xiaomei
Published in
Journal of Translational Medicine
BackgroundAtherosclerosis is a chronic vascular disease posing a great threat to public health. We investigated whether rosuvastatin (RVS) enhanced autophagic activities to inhibit lipid accumulation and polarization conversion of macrophages and then attenuate atherosclerotic lesions.MethodsAll male Apolipoprotein E-deficient (ApoE−/−) mice were f...
