The genetic influence on human vocal pitch in tonal and non-tonal languages remains largely unknown. In tonal languages, such as Mandarin Chinese, pitch changes differentiate word meanings, whereas in non-tonal languages, such as Icelandic, pitch is used to convey intonation. We addressed this question by searching for genetic associations with int...
BackgroundSouth Asians are at higher risk for type 2 diabetes (T2D) than many other race/ethnic groups. Ectopic adiposity, specifically hepatic steatosis and visceral fat may partially explain this. Our objective was to derive metabolite risk scores for ectopic adiposity and assess associations with incident T2D in South Asians.MethodsWe examined 5...
BACKGROUND: Hmong-Mien (HM) speakers are linguistically related and live primarily in China, but little is known about their ancestral origins or the evolutionary mechanism shaping their genomic diversity. In particular, the lack of whole-genome sequencing data on the Yao population has prevented a full investigation of the origins and evolutionary...
Counterfactual reasoning helps people to learn from the past to prepare for the future. In contrast to English with counterfactual markers that directly signal counterfactual reasoning, Mandarin Chinese indicates counterfactual reasoning by counterfactuality enhancers, which enhance rather than directly signal entry into the counterfactual realm. T...
BackgroundAsian Americans (AAs) are experiencing increased rates of anti-Asian racism during COVID-19. Experiences of racism, whether personal or collective, constitute stress and psychosocial trauma that negatively impact mental and physical health.ObjectivesExamine subgroup differences in rates of personal experience of discrimination and COVID-r...
Funder: Cancer Research UK; doi: http://dx.doi.org/10.13039/501100000289 / Funder: Scientex Foundation / Funder: Estée Lauder Companies / Funder: Vistage Malaysia / Funder: Yayasan PETRONAS / Funder: Yayasan Sime Darby; doi: http://dx.doi.org/10.13039/100019524 / Breast cancer exhibits significant heterogeneity, manifesting in various subtypes that...
Acknowledgements: We want to thank all the study participants, clinicians, and support staff at Subang Jaya Medical Centre and University Malaya Medical Centre for their generous contributions to the Malaysian Mammography Study (MyMammo) and the Malaysian Breast Cancer Genetic Study (MyBrCa) studies. We thank all the research associates, scientists...
The transferability and clinical value of genetic risk scores (GRSs) across populations remain limited due to an imbalance in genetic studies across ancestrally diverse populations. Here we conducted a multi-ancestry genome-wide association study of 156,319 prostate cancer cases and 788,443 controls of European, African, Asian and Hispanic men, ref...
BACKGROUND: In Vietnam and many developing countries, private healthcare is increasingly being leveraged by governments to complement public services and increase health service access and utilisation. Extensive understanding of patterns of utilisation of private over public health services, and the rationale for such consumer decisions, is importa...
Acknowledgements: This research was supported primarily by US National Institutes of Health (NIH) grant R01CA188214 (to W.Z.), Anne Potter Wilson Chair endowment from the Vanderbilt University School of Medicine (to W.Z.), and NIH grant R37CA227130 and R01CA269589 (to X.G.). Sample preparation and genotyping assays at Vanderbilt University were con...
