Tuerlings, Margo van Hoolwerff, Marcella Houtman, Evelyn Suchiman, Eka H E D Lakenberg, Nico Mei, Hailiang van der Linden, Enrike H M J Nelissen, Rob R G H H Ramos, Yolande Y F M Coutinho de Almeida, Rodrigo
...
Published in
Arthritis & rheumatology (Hoboken, N.J.)
The aim of this study was to identify key determinants of the interactive osteoarthritis (OA) pathophysiological processes of subchondral bone and cartilage. We performed RNA sequencing on macroscopically preserved and lesioned OA subchondral bone of patients that underwent joint replacement surgery due to OA (N=24 pairs; 6 hips, 18 knees, RAAK-stu...
Salinas, Evelia
Hyaline articular cartilage, the smooth, white, tissue that is found at the ends of long bones, does not regenerate. Although it is a mechanically robust tissue that repeatedly supports up to six-times body weight, its innate lack of vasculature limits access to nutrients and progenitor cells that are necessary for tissue repair. Currently, clinici...
Vazquez, Kelly J Andreae, Jacob T Henak, Corinne R
Published in
Journal of the mechanical behavior of biomedical materials
Cartilage breaks down during mechanically-mediated osteoarthritis (OA). While previous research has begun to elucidate mechanical, structural and cellular damage in response to cyclic loading, gaps remain in our understanding of the link between cyclic cartilage loading and OA-like mechanical damage. Thus, the aim of this study was to quantify irre...
Cloos, Martijn A Assländer, Jakob Abbas, Batool Fishbaugh, James Babb, James S Gerig, Guido Lattanzi, Riccardo
Published in
Journal of magnetic resonance imaging : JMRI
Quantitative MRI can detect early changes in cartilage biochemical components, but its routine clinical implementation is challenging. To introduce a novel technique to measure T1 and T2 along radial sections of the hip for accurate and reproducible multiparametric quantitative cartilage assessment in a clinically feasible scan time. Reproducibilit...
Quinn, T. M. Morel, V.
Published in
Biomechanics and Modeling in Mechanobiology
Cartilage matrix mechanical function is largely determined by interactions between the collagen fibrillar network and the proteoglycan gel. Although the molecular physics of these matrix constituents have been characterized and modern imaging methods are capable of localized measurement of molecular densities and orientation distributions, theoreti...
Khalilifar, Mohammad Ali Eslaminejad, Mohamadreza Baghaban Ghasemzadeh, Mohammad Hosseini, Samaneh Baharvand, Hossein
Published in
Cell Journal (Yakhteh)
Objective Systematic studies indicate a growing number of clinical studies that use mesenchymal stem cells (MSCs) for the treatment of cartilage lesions. The current experimental and preclinical study aims to comparatively evaluate the potential of MSCs from a variety of tissues for the treatment of cartilage defect in rabbit’s knee which has not p...
Li, Xiaofei Sun, Yueli Zhou, Zhilun Zhang, Dongye Jiao, Jian Hu, Minyi Hassan, Chaudhry Raza Qin, Yi-Xian
Published in
Ultrasound in medicine & biology
The purpose of this study was to evaluate the effect of low-intensity ultrasound on articular cartilage and subchondral bone alterations in joints under normal and functional disuse conditions during osteoarthritis (OA) progression. Sixty 5-month-old female Sprague-Dawley rats were randomly assigned to six groups (n=10/group): Age-match group, OA g...
Reuter, Thomas Hurschler, Christof
Published in
Current Directions in Biomedical Engineering
The mechanical parameters of articular cartilage estimated from indentation tests depend on the constitutive model adopted to analyze the data. In this study, we present a 3D-FE-based method to determine the biomechanical properties of equine articular cartilage from stress relaxation indentation tests (ε = 6 %, t = 1000 s) whereby articular cartil...
Reuter, Thomas Hurschler, Christof
Published in
Current Directions in Biomedical Engineering
Mechanical parameters of hard and soft tissues are explicit markers for quantitative tissue characterization. In this study, we present a biphasic 3D-FE-based method to determine the biomechanical properties of equine articular cartilage from creep indentation tests (F = 0.1 N, t = 1000 s). The FE-model computation was optimized by exploiting the a...
Su, Alvin W. Chen, Yunchan Dong, Yao Wailes, Dustin H. Wong, Van W. Chen, Albert C. Cai, Shengqiang Bugbee, William D. Sah, Robert L.
Published in
Journal of biomechanics
Articular cartilage is susceptible to impact injury. Impact may occur during events ranging from trauma to surgical insertion of an OsteoChondral Graft (OCG) into an OsteoChondral Recipient site (OCR). To evaluate energy density as a mediator of cartilage damage, a specialized drop tower apparatus was used to impact adult bovine samples while measu...
