Takeuchi, Tsutomu Tanaka, Yoshiya Higashitani, Chieri Iwai, Megumi Komatsu, Kanji Akazawa, Rio Lademacher, Christopher
Published in
Modern rheumatology
Many patients with rheumatoid arthritis (RA) are not able to achieve long-term disease remission. This phase 2a study (NCT02884635) evaluated the efficacy, safety, pharmacokinetics, and pharmacodynamics of the novel, oral, gonadotropin-releasing hormone antagonist, ASP1707, in combination with methotrexate (MTX) for treatment of RA. Postmenopausal ...
Liao, Kangsheng Su, Xiaohui Lei, Kawai Liu, Zhongqiu Lu, Linlin Wu, Qibiao Pan, Hudan Huang, Qingchun Zhao, Yue Wang, Mingming
...
Published in
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Disease-modifying antirheumatic drugs (DMARDs) are the first line medications to treat rheumatoid arthritis (RA), a chronic and systemic autoimmune disease affecting multiple joints. Sinomenine (SIN) is thought a natural DMARD (nDMARD) and effectively utilized to treat RA in clinic for several decades in China. Here we reported that it is not metho...
Li, Yunzhi Dai, Minxing Wang, Lulu Wang, Guodong
Published in
Journal of ethnopharmacology
Aralia echinocaulis has been used in traditional medicines in China and exhibits good effects on rheumatoid arthritis (RA). Aralia echinocaulis is rich in polysaccharides and glycosides. This study aims to explore the effect of total polysaccharide and glycoside (TPG) from A. echinocaulis on an RA rat model and the role of alterations in gut microb...
Bernardes, Ana Catharina Fernandes Perei... Matosinhos, Rafaela Cunha de Paula Michel Araújo, Marcela Carolina... Barros, Camila Helena de Oliveira Aguiar Soares, Rodrigo Dian Costa, Daniela Caldeira Sachs, Daniela Saúde-Guimarães, Dênia Antunes
Published in
Journal of ethnopharmacology
Lychnophora trichocarpha and Lychnophora passerina are species used in folk medicine to treat inflammation, pain, and rheumatism. Previous studies have demonstrated the anti-inflammatory effect of ethanol extracts of these species and identified that sesquiterpene lactones contribute to this activity. Gout is an acute inflammatory arthritis caused ...
Guo, Lina Chen, Yang Wang, Ting Yuan, Yu Yang, Yihua Luo, Xiaoli Hu, Shuo Ding, Jinsong Zhou, Wenhu
Published in
Journal of controlled release : official journal of the Controlled Release Society
Methotrexate (MTX) has been used as an anchor drug for the treatment of rheumatoid arthritis (RA), while the patients with chronic MTX administration suffer from severe side-effects. To this end, targeted delivery of MTX by nanomedicine has attracted great interest. In this work, we aimed to employ metal-organic frameworks (MOFs) as nanocarrier to ...
Farag, Yomna Taher, Heba Seleem, Noha Mostafa Fahim, Diana Marzouk, Huda
Published in
Egyptian Rheumatology and Rehabilitation
BackgroundFamilial Mediterranean fever (FMF) is an autosomal recessive auto-inflammatory disease. Arthritis in early-onset FMF is a common finding. The aim of this study was to assess frequency of arthritis in 200 Egyptian children with FMF and also to detect its clinical characteristics, response to colchicine treatment, its effect on disease seve...
Gosselt, Helen R Verhoeven, Maxime M A de Rotte, Maurits C F J Pluijm, Saskia M F Muller, Ittai B Jansen, Gerrit Tekstra, Janneke Bulatović-Ćalasan, Maja Heil, Sandra G Lafeber, Floris P J G
...
Published in
Rheumatology and therapy
Methotrexate (MTX) constitutes the first-line therapy in rheumatoid arthritis (RA), yet approximately 30% of the patients do not benefit from MTX. Recently, we reported a prognostic multivariable prediction model for insufficient clinical response to MTX at 3 months of treatment in the treatment in the Rotterdam Early Arthritis Cohort (tREACH), inc...
Pappas, Dimitrios A Brittle, Christine Mossell, James E 3rd Withers, Johanna B Lim-Harashima, Jeraldine Kremer, Joel M
Published in
Rheumatology international
Tumor necrosis factor inhibitor (TNFi) therapies are often the first biologic therapy used to treat rheumatoid arthritis (RA) patients. However, a substantial fraction of patients do not respond adequately to TNFi therapies. A test with the ability to predict response would inform therapeutic decision-making and improve clinical and financial outco...
Loyola-Sanchez, Adalberto Pelaez-Ballestas, Ingris Crowshoe, Lynden Lacaille, Diane Henderson, Rita Rame, Ana Linkert, Tessa White, Tyler Barnabe, Cheryl
Published in
BMC Health Services Research
BackgroundArthritis is a highly prevalent disease and leading cause of disability in the Indigenous population. A novel model of care consisting of a rheumatology outreach clinic in an on-reserve primary healthcare center has provided service to an Indigenous community in Southern Alberta since 2010. Despite quality assessments suggesting this mode...
Smistad, Marit Wolff, Cecilia Tollersrud, Tore Tømmerberg, Vibeke Phythian, Clare Kampen, Annette Hegermann Jørgensen, Hannah Joan
Published in
Acta Veterinaria Scandinavica
BackgroundOutbreaks of infectious arthritis in young lambs associated with Streptococcus dysgalactiae subspecies dysgalactiae (SDSD) lead to reduced animal welfare, increased use of antibiotics and economic losses for sheep farmers. Understanding risk factors is essential when developing strategies to prevent such outbreaks. This questionnaire-base...
