Chen, Qiang Jiao, Jiuyang Wang, Youyuan Mai, Zhihui Ren, Jing He, Sijie Li, Xiaolan Chen, Zheng
Published in
BMC Molecular and Cell Biology
BackgroundArecoline is an alkaloid natural product found in the areca nut that can induce oral submucous fibrosis and subsequent development of cancer. However, numerous studies have shown that arecoline may inhibit fibroblast proliferation and prevent collagen synthesis.ResultsHigh doses of arecoline (> 32 μg/ml) could inhibit human oral fibroblas...
Dasgupta, Romi Saha, Indraneel Ray, Prajna Paramita Maity, Aniruddha Pradhan, Debajoyti Sarkar, Hari Prasad Maiti, B R
Published in
Archives of physiology and biochemistry
Arecoline has biomedical importance, but it has untoward side effects on endocrine functions. The aim is to investigate its role on adrenal activity under thermal stress by ultrastructural and hormonal parameters in mice. Cold (4 °C) or heat (37 °C) stress, or arecoline (10 mg/kg body wt), each for 7 days in cold or heat stress stimulated adrenocor...
Serikuly, Nazar Alpyshov, Erik T Wang, DongMei Wang, JingTao Yang, LongEn Hu, GuoJun Yan, DongNi Demin, Konstantin A Kolesnikova, Tatyana O Galstyan, David
...
Published in
Progress in neuro-psychopharmacology & biological psychiatry
Arecoline is a naturally occurring psychoactive alkaloid with partial agonism at nicotinic and muscarinic acetylcholine receptors. Arecoline consumption is widespread, making it the fourth (after alcohol, nicotine and caffeine) most used substance by humans. However, the mechanisms of acute and chronic action of arecoline in-vivo remain poorly unde...
Saha, Indraneel Chakraborty, Suman Bhusan Chatterjee, Aniruddha Pradhan, Debajyoti Chatterji, Urmi Maiti, B R
Published in
Archives of physiology and biochemistry
Arecoline is known to cause endocrine dysfunction. In the current article role of arecoline on pineal-testis activity was investigated in hypothyroid rats induced by propylthiouracil (PTU). PTU treatment caused thyroid dysfunction ultrastructurally with a fall in T3 and T4 levels followed by a rise of thyroid stimulating hormone (TSH) level. Pineal...
Islam, Shajedul Uehara, Osamu Matsuoka, Hirofumi Kuramitsu, Yasuhiro Adhikari, Bhoj Raj Hiraki, Daichi Toraya, Seiko Jayawardena, Asiri Saito, Ichiro Muthumala, Malsantha
...
Published in
Clinical Epigenetics
BackgroundDNA hypermethylation of tumor suppressor genes is observed in precancerous lesions and oral cancer of individuals with the habits of betel quid (BQ) chewing. SIRT1 has been identified as playing a role in the maintenance of epithelial integrity, and its alteration is often related to carcinogenesis. However, the methylation and transcript...
Laskar, Jeny Sengupta, Mahuya Choudhury, Yashmin
Published in
Pharmacological Reports
BackgroundMetformin, a widely used anti-diabetic drug has gained enormous attention as an anticancer agent. This study seeks to investigate the efficacy of metformin in ameliorating aqueous extract of betelnut (AEBN) and arecoline induced carcinogenesis in a murine model.MethodsSwiss albino mice were exposed to AEBN (2 mg ml 1) and arecoline (10 μg...
Gu, Liqun Xie, Changqing Peng, Qian Zhang, Jiaming Li, Jiada Tang, Zhangui
Published in
Toxicology
Arecoline, the major active ingredient of the betel nut, is involved in the pathogenesis of oral submucous fibrosis. However, the underlying mechanism of this pathogenesis remains unclear. In this study, we found that arecoline suppresses the cell proliferation of the HaCaT epithelial cell and induces cell cycle arrest at the G1/S phase with an IC5...
Dai, Zhuo Zhu, Bingyu Yu, Huiqiao Jian, Xinchun Peng, Jieying Fang, Changyun Wu, Yingfang
Published in
Archives of oral biology
To detect the expression of protein light chain 3 (LC3) and p62-SQSTM1 (p62) in the lamina propria of oral submucous fibrosis (OSF) and to determine the association of autophagy with OSF. To investigate the role of autophagy in angiogenesis of human umbilical vein endothelial cells (HUVECs) and to assess whether this effect was induced by arecoline...
Chang, Chih-Hsiang Chen, Mei-Chih Chiu, Te-Huan Li, Yu-Hsuan Yu, Wan-Chen Liao, Wan-Ling Oner, Muhammet Yu, Chang-Tze Ricky Wu, Chun-Chi Yang, Tsung-Ying
...
Published in
Toxins
Arecoline is the primary alkaloid in betel nuts, which are known as a risk factor for oral submucosal fibrosis and oral cancer. Lung cancer is a severe type of carcinoma with high cell motility that is difficult to treat. However, the detailed mechanisms of the correlation between Arecoline and lung cancer are not fully understood. Here, we investi...
Shakya, Barkha Siddique, Yasir Hasan
Published in
The Journal of Basic and Applied Zoology
BackgroundArecoline (an alkaloid) has been reported as a potent cytotoxic as well as genotoxic agent but its neurotoxic effects are limited.Material and methodsIn the present study, we evaluated the neurotoxic effects and changes in life cycle parameters of Drosophila melanogaster on exposing the flies to 5, 10, 20, 40 and 80 μM of arecoline for 5 ...