Kumar, Ketan Crobu, Lucien Thiam, Rokhaya Mandal, Chandi C. Sterkers, Yvon Prajapati, Vijay Kumar
Published in
Parasite
Visceral leishmaniasis, a life-threatening vector-borne illness that disproportionately affects children and elderly immunocompromised people, is a primary tropical neglected disease. No apoptotic partner proteins have yet been reported in Leishmania donovani, while their identification could contribute to knowledge on parasite cell death and the e...
Yaya, Joël Abel Gbaweng Zingue, Stephane Offermann, Anne Feunaing Toko, Roméo Kang, Duan Bapong, Elisée Henoumont, Céline Laurent, Sophie Sailer, Verena-Wilbeth Kirfef, Jutta
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Published in
Journal of ethnopharmacology
Commiphora kerstingii Engl is a tree which is 20-30 m in height and commonly called "ararrabi" in Hausa. It is found in the Sahelian region (Cameroon, Chad, and Nigeria) where it is utilized for the treatment of several ailments including cancer. This study was aimed at investigating the chemical constituents and cytotoxic effect of extracts and is...
Chen, Chih-Chen Huang, Chun-Yen Yu, Ya-Chun Shiu, Li-Yen Chang, Chi-Chang Chou, Yu-Ta Huang, S Joseph
Published in
Journal of ethnopharmacology
Endometriosis is a common gynecological disorder that manifests as chronic pelvic pain and subfertility. Guizhi Fuling Wan (GFW), which contains five herbs, was first described in Chinese canonical medicine to treat qi stagnation and circulation. Although the inhibition of endometriosis by GFW has been previously demonstrated, its efficacy could po...
Kazakova, Anna Frydrych, Ivo Jakubcová, Nikola Pokorný, Jan Lišková, Barbora Gurská, Soňa Buriánová, Renata Přibylka, Adam Džubák, Petr Hajdúch, Marián
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Published in
European journal of medicinal chemistry
Starting from benzyl 30-oxobetulinate and 30-oxobetulin diacetate, substituted dienes were synthesized and subjected to Diels-Alder reaction, yielding a variety of triterpenoid phthalates, phthalimides, and related derivatives. A total of 55 new compounds were prepared and tested for in vitro cytotoxic activity against eight cancer cell lines and t...
Cheon, Se-Yun Kim, Ye Eun Yang, Eun-Sun Lim, Yoo Jin Bae, Chang-Hwan Jin, Jung-Sook Park, Wonyoung Kim, Bo-Sung Kim, Chorong Cho, Hyunsung
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Published in
European journal of medicinal chemistry
Inhibition of lactate dehydrogenase (LDH) has emerged as a promising cancer therapy strategy due to its essential role in the metabolic transformation of cancer cells. In this study, 53 derivatives of 1-hydroxy(and 1-alkoxy, 1-acyloxy)indoles were designed, synthesized, and biologically evaluated. Several multi-substituted 1-hydroxy(and 1-alkoxy, 1...
Li, Dong Yao, Huan Cao, Xiaohan Han, Xingfa Song, Tianzeng Zeng, Xianyin
Published in
Journal of reproductive immunology
Active immunization against gonadotropin-releasing hormone (GnRH) affects the immune system by inhibiting testosterone production. Our previous study investigated the effects of GnRH immunization on thymic T-cell generation, migration, and colonization in peripheral immune organs. However, the mechanisms by which GnRH immunization influences B cell...
Liu, Tianyu Li, Ling Yang, Yanchao Li, Jiarou Yang, Xutong Li, Lei Zheng, Ziyao Yang, Boyu Zhang, Peiyu Liu, Haiyan
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Published in
Fish & shellfish immunology
The current study was conducted to investigate the effects of chronic cold stress and thermal stress on the growth performance, hepatic oxidative status, immune response, apoptosis and gut microbiota in juvenile hybrid sturgeon. The fish (initial mean weight: 21.4 ± 0.3 g) was reared at three temperatures (14 °C, 22 °C, and 30 °C) for 16 d, which w...
Yang, Gang Fu, Jinsong Wang, Jiawei Ding, Mei
Published in
Molecular biotechnology
Lung adenocarcinoma (LUAD) is a malignant tumor with the characteristics of progressive advancement and high mortality rate worldwide. We aimed to explore the role and mechanism of helicase Lymphoid-Specific (HELLS) in LUAD. Bioinformatics databases were applied to predict HELLS and kinesin family member (KIF)11 expression in LUAD tissues. The expr...
Li, Jingyang Zhang, Di Wang, Shaohui Yu, Peng Sun, Jiayi Zhang, Yi Meng, Xianli Li, Juan Xiang, Li
Published in
Journal of advanced research
Baicalein, a bioactive component of Scutellaria baicalensis Georgi, has been shown to promote apoptosis in non-small cell lung cancer cells. However, previous studies have not determined if baicalein exerts proapoptotic effects by modulating the metabolic pathways. To investigate if baicalein induces apoptosis in lung cancer cells by modulating the...
Yıldırım, Onurcan Seçme, Mücahit Dodurga, Yavuz Mete, Gülçin Abban Fenkci, Semin Melahat
Published in
Biological trace element research
Medullary thyroid cancer (MTC) is a highly aggressive and chemotherapy-resistant cancer originating from the thyroid's parafollicular C cells. Due to its resistance to conventional treatments, alternative therapies such as boric acid have been explored. Boric acid, a boron-based compound, has shown anticarcinogenic effects, positioning it as a pote...