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with Antiviral drugs as keyword

Mechanistic exploration of COVlD-19 antiviral drug ritonavir on anaerobic digestion through experimental validation coup...

Published in Journal of hazardous materials

Aggregation of antiviral drugs (ATVs) in waste activated sludge (WAS) poses considerable environmental risk, so it is crucial to understand the behavior of these agents during WAS treatment. This study investigated the effects of ritonavir (RIT), an ATV used to treat human immunodeficiency virus infection and coronavirus disease 2019, on anaerobic ...

Atranorin inhibits Zika virus infection in human glioblastoma cell line SNB-19 via targeting Zika virus envelope protein...

Published in Phytomedicine : international journal of phytotherapy and phytopharmacology

Zika virus (ZIKV) is a single-stranded RNA flavivirus transmitted by mosquitoes. Its infection is associated with neurological complications such as neonatal microcephaly and adult Guillain-Barré syndrome, posing a serious threat to the health of people worldwide. Therefore, there is an urgent need to develop effective anti-ZIKV drugs. Atranorin is...

Drugs targeting structural and nonstructural proteins of the chikungunya virus: A review.

Published in International journal of biological macromolecules

Chikungunya virus (CHIKV) is a single positive-stranded RNA virus of the Togaviridae family and Alphavirus genus, with a typical lipid bilayer envelope structure, and is the causative agent of human chikungunya fever (CHIKF). The U.S. Food and Drug Administration has recently approved the first chikungunya vaccine, Ixchiq; however, vaccination rate...

Antiviral drugs in animal-derived matrices : A review

The ban of antiviral drugs in food-producing animals in several parts of the world, latest by Commission Delegated Regulation (EU) 2022/1644, has increased the need for food control laboratories to develop analytical methods and perform official controls. However, little is known about antiviral drugs, their use, and its analysis in food-producing ...

Simultaneous quantification method for multiple antiviral drugs in serum using isotope dilution liquid chromatography-ta...

Published in Journal of chromatography. B, Analytical technologies in the biomedical and life sciences

We describe the simultaneous quantification of six antiviral drugs in serum based on high-performance liquid chromatography-tandem mass spectrometry (LC-MS/MS). The target drugs-hydroxychloroquine, chloroquine, favipiravir, umifenovir, ritonavir, and lopinavir-were extracted and purified from serum with 75 % v/v methanol as the precipitant reagent....

De novo designed inhibitor has high affinity to four variants of the RBD of S-glycoprotein of SARS-CoV-2 - an in silico ...

Published in Journal of biomolecular structure & dynamics

In the years since the rapid invasion of SARS-CoV-2, the world community has fully understood the extent of the danger of this new pathogen. And also the speed with which he is able to adapt both to humans as a species and to the means of combat that are introduced. However, this has already resulted in millions of lost lives and this situation may...

Inhibiting immunoregulatory amidase NAAA blocks ZIKV maturation in Human Neural Stem Cells.

Published in Antiviral research

Recent evidence suggests that lipids play a crucial role in viral infections beyond their traditional functions of supplying envelope and energy, and creating protected niches for viral replication. In the case of Zika virus (ZIKV), it alters host lipids by enhancing lipogenesis and suppressing β-oxidation to generate viral factories at the endopla...

Stability and WBE biomarkers possibility of 17 antiviral drugs in sewage and gravity sewers.

Published in Water research

Wastewater-based epidemiology (WBE) is a promising technique for monitoring the rapidly increasing use of antiviral drugs during the COVID-19 pandemic. It is essential to evaluate the in-sewer stability of antiviral drugs in order to determine appropriate biomarkers. This study developed an analytical method for quantification of 17 typical antivir...

Research progress on the nucleoside/nucleotide-loaded nanomedicines.

Published in Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences

核苷类药物在肿瘤和病毒等疾病的临床治疗中占据重要地位，但这类药物生物利用度低，缺乏靶向性，入胞效率较低，极大地制约了临床应用。设计并利用纳米载体，通过提升载药效率与药物利用度、维持药效与系统稳定性、调整载体与药物分子的结合能力、修饰特异性分子实现主动靶向等方式，能够改善核苷类药物的生理学性质。本文从核苷类药物纳米递送系统设计策略出发，综述了针对核苷类药物的纳米递送系统载体设计及包载效果。.