van der Pol, Simon Postma, Maarten J Boersma, Cornelis
Published in
The European journal of health economics : HEPAC : health economics in prevention and care
We perform a cost-effectiveness analysis (CEA) and budget impact analysis (BIA) of baloxavir marboxil compared to current care in the Netherlands for patients at risk of influenza-related complications, including patients with comorbidities and the elderly. In the CEA, a decision tree model was developed to assess the cost-effectiveness of baloxavi...
M Hassen, Bassel Rashedy, Sarah H Mostafa, Ahmed Mahrous, Noura Nafie, Mohamed S Elebeedy, Dalia Abdel Azeiz, A Z
Published in
Natural product research
Influenza is a contagious viral infection of the respiratory tract, affecting nearly 10% of the world's population, each year. The aim of this study was to extract and identify antiviral compounds against the influenza-A virus (H1N1) from different species of Egyptian marine algae. Three samples of marine macroalgae species were extracted and the a...
Chen, Zilu Li, Dongliang Wang, Tianliang Li, Yaqin Qin, Panpan Zhu, Hongsen Zhang, Mengjia Li, Wentao Yu, Linyang Duan, Hong
...
Published in
Phytomedicine : international journal of phytotherapy and phytopharmacology
Pseudorabies virus (PRV), a member of the family Herpesviridae, is responsible for significant economic losses in the pig industry and has recently been associated with human viral encephalitis, leading to severe neurological symptoms post-recovery. Despite the widespread impact of PRV, there are currently no approved effective drugs for treating P...
Lesenfants, Cindy Soualmia, Feryel Chaaya, Nancy Goffin, Eric Colson, Thomas Garigliany, Mutien-Marie Chavatte, Philippe Snoek, Robert Andrei, Graciela Reboud-Ravaux, Michèle
...
editorial reviewed / The COVID-19 pandemic has highlighted the urgent need to develop new antivirals to treat emergent respiratory infections. As a promising approach to combat SARS-CoV-2 and other respiratory viral infections, we designed and evaluated novel inhibitors of the Transmembrane Serine Protease 2 (TMPRSS2), as well as Human Airway tryps...
Herbin, Camille; Jadoul, Pascale; Hosten, Edouard; 161407; Gerday, Amandine; Luyckx, Mathieu; Squifflet, Jean-Luc; Perlepe, Vasiliki; Maillard, Charlotte;
BACKGROUND: Cervicitis, an infectious or noninfectious inflammation of the cervix, encompasses a wide range of clinical conditions, from asymptomatic infections to severe lesions, making its diagnosis difficult. Acute cervicitis may develop into pelvic inflammatory disease. In patients with cervicitis, current guidelines recommend testing for herpe...
Plastiras, Orfeas-Evangelos Bouquet, Peggy Raczkiewicz, Imelda Belouzard, Sandrine Martin de Fourchambault, Esther Dhainaut, Jérémy Dacquin, Jean-Philippe Goffard, Anne Volkringer, Christophe
The antiviral effect of four porphyrin-based Metal-Organic Frameworks (PMOFs) with Al and Zr, namely Al-TCPP, PCN-222, PCN-223 and PCN-224 was assessed for the first time against HCoV-229E, two highly pathogenic coronaviruses (SARS-CoV-2 and MERS-CoV) and hepatitis C virus (HCV). Infection tests in vitro were done under dark or light exposure for d...
Whitmore, Vanessa
Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) can cause morbidity and mortality in pigs of all ages with a high prevalence, causing an estimated product loss of $664 million annually in the United States in 2013. While vaccines exist, additional biosecurity measures are key to prevent and eliminate this virus from herds. This virus ca...
Laïb, Allan
Cette thèse explore le potentiel des champignons comme source de composés bioactifs, particulièrement dans le contexte de la recherche médicale et pharmaceutique. Les champignons, grâce à leur diversité chimique, offrent une multitude de métabolites secondaires aux propriétés thérapeutiques variées, incluant des activités antibactériennes, anticanc...
Dash, Rudra N Prabhudutta, Mamidi De, Saikat Swain, Ranjit P Moharana, Alok K Subudhi, Bharat B Chattopadhyay, Soma
Published in
Molecular diversity
Chikungunya virus infection has become a global health concern because of its high rates of morbidity and mortality in patients with preexisting conditions. Inflammation and arthritis are the major symptoms of CHIKV that persist even after clearance of CHIKV. To develop an antiviral that can reduce infection and manage inflammation independent of t...
Patil, Ketki Ayyar, B Vijayalakshmi Neill, Frederick H Bode, Lars Estes, Mary K Atmar, Robert L Ramani, Sasirekha
Published in
bioRxiv : the preprint server for biology
Human noroviruses (HuNoVs) are the leading cause of acute gastroenteritis worldwide. Currently, there are no targeted antivirals for the treatment of HuNoV infection. Histo-blood group antigens (HBGAs) on the intestinal epithelium are cellular attachment factors for HuNoVs; molecules that block the binding of HuNoVs to HBGAs thus have the potential...
