Bazié, Wilfried Wenceslas Somé, Diane Yirgnur Traoré, Isidore Tiandiogo Sanon, Anselme Konaté, Issouf Tassembedo, Souleymane Taofiki, Ajani Ousmane Kania, Dramane Ouédraogo, Abdoulaye Vuylsteke, Bea
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Published in
BMC Infectious Diseases
BackgroundIn people living with HIV/AIDS (PLWHA), initiation of antiretroviral therapy (ART) leads to sustained effective suppression of viral replication and increasing CD4 + T cell count. However, a fraction of ART-treated patients still fail to reach adequate CD4 + T cell number despite a suppressed viral load (VL), and this phenomenon is define...
Affi, Roseline Gabillard, Delphine Kouame, Gérard Menan Ntakpe, Jean Baptiste Moh, Raoul Badje, Anani Danel, Christine Inwoley, André Eholié, Serge P Anglaret, Xavier
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Published in
HIV medicine
We report the association between pre-antiretroviral therapy (pre-ART) soluble vascular cell adhesion molecule-1 (sVCAM-1) levels and long-term mortality in HIV-infected West African adults participating in a trial of early ART in West Africa (Temprano ANRS 12136 trial). The ART-naïve HIV-infected adults were randomly assigned to start ART immediat...
Atugba, Thomas Abugbilla Aninagyei, Enoch Binka, Fred Newton Duedu, Kwabena Obeng
Published in
AIDS and behavior
In Ghana, HIV status disclosure to partners is voluntary. This study sought to determine the factors associated with HIV status disclosure to partners among antiretroviral therapy (ART) clients in the Upper East Region. A matched case-control study (1:1) was carried out in nine ART sites in the Upper East region in which 100 ART sexually active cli...
Bogart, Laura M Shazi, Zinhle MacCarthy, Sarah Mendoza-Graf, Alexandra Wara, Nafisa J Zionts, Dani Dube, Nduduzo Govere, Sabina Bassett, Ingrid V
Published in
AIDS and behavior
We used the Practical, Robust Implementation and Sustainability Model to evaluate implementation of South Africa's Central Chronic Medicine Dispensing and Distribution (CCMDD) program, a differentiated service delivery program which allows clinically stable HIV-positive patients to receive antiretroviral therapy refills at clinic- or community-base...
Kabarambi, Anita Balinda, Sheila Abaasa, Andrew Cogill, Dolphina Orrell, Catherine
Published in
AIDS research and therapy
There are limited data exploring antiretroviral therapy (ART) changes and time to change among South Africa young people living with HIV/AIDS. We describe the time to first drug switch, which includes ART regimen change (three drug switch) and substitutions (single drug switch). We describe common reasons for ART switch among young people aged 10 t...
Jackson, Christi Rehman, Andrea M. McHugh, Grace Gonzalez-Martinez, Carmen Ngwira, Lucky G. Bandason, Tsitsi Mujuru, Hilda Odland, Jon O. Corbett, Elizabeth L. Ferrand, Rashida A.
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Published in
BMC Pediatrics
Background We investigated risk factors for sustained virological non-suppression (viral load ≥ 1000 copies/ml on two tests 48 weeks apart) among children and adolescents accessing HIV care in public sector clinics in Harare, Zimbabwe and Blantyre, Malawi. Methods Participants were enrolled between 2016 and 2019, were aged 6–19 years, living with H...
Arubaku, Wilfred Kwizera, Godfrey Tusubira, Deusdedit Kanyesigye, Michael Chamut, Steffany Seymour, Brittany Anne Siedner, Mark J. Niyonzima, Vallence Najjuma, Josephine N. Maling, Samuel
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Published in
BMC Oral Health
Background Oral diseases are estimated to affect half of people living with HIV in the western world, and are often marked by pain, discomfort, disfigurement and reduced quality of life. Both HIV-specific and antiretroviral therapy-associated oral diseases have been found in this population. However, the prevalence, correlates and treatment needs o...
Wekesa, P. McLigeyo, A. Owuor, K. Mwangi, J. Ngugi, E.
Published in
BMC Infectious Diseases
Background Retention of patients who are receiving antiretroviral therapy (ART) remains a challenge especially in the setting of rapid expansion of HIV services. Retention in care remains vital to the HIV care continuum, and has been associated with viral suppression and improved survival. This study aimed to ascertain survival rates, time to loss ...
Serrano-Villar, Sergio Wu, Kunling Hunt, Peter W Lok, Judith J Ron, Raquel Sainz, Talía Moreno, Santiago Deeks, Steven G Bosch, Ronald J
Published in
EBioMedicine
While increased CD8 counts and low CD4/CD8 ratio during treated HIV correlate with immunosenescence, their additional predictive values to identify individuals with HIV at higher risk of clinical events remain controversial. We selected treatment-naive individuals initiating ART from ACTG studies 384, 388, A5095, A5142, A5202, and A5257 who had ach...
Zhao, Ying Hohlfeld, Ameer Namale, Phiona Meintjes, Graeme Maartens, Gary Engel, Mark E
Published in
Journal of acquired immune deficiency syndromes (1999)
Integrase strand transfer inhibitors (InSTIs) decrease HIV plasma viral load faster than other antiretroviral classes. More rapid viral load decline has been associated with higher risk of immune reconstitution inflammatory syndrome (IRIS). There are conflicting reports on the association between InSTI and IRIS. We performed a systematic review and...
