Papaioannou, Nikos E. Salei, Natallia Rambichler, Stephan Ravi, Kaushikk Popovic, Jelena Küntzel, Vanessa Lehmann, Christian H. K. Fiancette, Remi Salvermoser, Johanna Gajdasik, Dominika W.
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Published in
Nature Communications
Type 2 conventional dendritic cells (cDC2) are important immune activators in adults, but their development and functions at the neonatal stage remain unclear. Here the authors show, using fate-mapping and single-cell RNA sequencing, that neonatal cDC2 come from multiple origins, but converge functionally as potent immune activators upon proper sti...
Mo, Chan Xie, Shuwen Liu, Bin Zhong, Weichao Zeng, Ting Huang, Sha Lai, Yuqi Deng, Guanghui Zhou, Chuying Yan, Weixin
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Published in
Cell Death & Disease
Liver fibrosis is a course of chronic liver dysfunction, can develop into cirrhosis and hepatocellular carcinoma. Inflammatory insult owing to pathogenic factors plays a crucial role in the pathogenesis of liver fibrosis. Indoleamine 2,3-dioxygenase 1 (IDO1) can affect the infiltration of immune cells in many pathology processes of diseases, but it...
Hilligan, Kerry L. Tang, Shiau-Choot Hyde, Evelyn J. Roussel, Elsa Mayer, Johannes U. Yang, Jianping Wakelin, Kirsty A. Schmidt, Alfonso J. Connor, Lisa M. Sher, Alan
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Published in
Nature Communications
Antigen presenting cells induce CD4+ T helper (Th) differentiation upon pathogen encounters. Here the authors use fluorescently-labeled bacteria, helminth and fungi to track and describe the functions of IRF4+ migratory type 2 dendritic cells and monocytes in the specific induction of Th1, Th2 or Th17 responses following skin inoculation.
Boretti, Alberto Banik, Bimal Castelletto, Stefania
Published in
Clinical Reviews in Allergy & Immunology
Ultraviolet blood irradiation (UBI) was used with success in the 1930s and 1940s for a variety of diseases. Despite the success, the lack of understanding of the detailed mechanisms of actions, and the achievements of antibiotics, phased off the use of UBI from the 1950s. The emergence of novel viral infections, from HIV/AIDS to Ebola, from SARS an...
Delaunay, Tiphaine Achard, Carole Grégoire, Marc Tangy, Frédéric Boisgerault, Nicolas Fonteneau, Jean-François
Published in
Methods in molecular biology (Clifton, N.J.)
Oncolytic immunotherapy efficacy relies partially on the induction of immunogenic tumor cell death following infection with oncolytic viruses (OV) to induce an antitumor immune response. Here, we describe a method to determine if an OV is able to induce such an immunogenic tumor cell death. This method consists in testing whether tumor cells lysed ...
Lebel, Marie-Ève Coutelier, Marie Galipeau, Maria Kleinman, Claudia L. Moon, James J. Melichar, Heather J.
Published in
Nature Communications
T cell tolerance is established in the thymus via interactions with medullary thymic epithelial cells (mTEC) expressing tissue-restricted self antigens. Here, the authors suggest, using new transgenic mouse lines and single cell transcriptome analyses, that specific mTEC subsets are associated with distinct T cell fates.
Rao, Anna Strauss, Otto Kokkinou, Efthymia Bruchard, Mélanie Tripathi, Kumar P. Schlums, Heinrich Carrasco, Anna Mazzurana, Luca Konya, Viktoria Villablanca, Eduardo J.
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Published in
Nature Communications
Murine ILCs can modulate T cell responses in MHCII-dependent manner. Here the authors show that human ILCs process and present antigens and induce T-cell responses upon exposure to IL-1-family cytokines; along with the article by Lehmann et al, this work elucidates how cytokines set context specificity of ILC-T cell crosstalk by regulating ILC anti...
Belabed, Meriem Mauvais, François-Xavier Maschalidi, Sophia Kurowska, Mathieu Goudin, Nicolas Huang, Jian-Dong Fischer, Alain de Saint Basile, Geneviève van Endert, Peter Sepulveda, Fernando E.
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Published in
Nature Communications
Kinesin-1 is a motor protein transporting cargo along microtubules. Here the authors show that kinesin-1 is required for antigen cross-presentation and coordinates endosome scission from early endosomes to allow sorting internalized cargoes towards the recycling endosomal or lysosomal compartments.
Kuroishi, Toshinobu Bando, Kanan Bakti, Reiska Kumala Ouchi, Gaku Tanaka, Yukinori Sugawara, Shunji
Published in
Scientific Reports
Nickel (Ni) is the most frequent metal allergen and induces Th1-dependent type-IV allergies. In local skin, epidermal Langerhans cells (LCs) and/or dermal dendritic cells (DCs) uptake antigens and migrate to draining lymph nodes (LNs). However, the subsets of antigen-presenting cells that contribute to Ni presentation have not yet been identified. ...
Gómez-Olarte, Sergio Bolaños, Natalia I Cuéllar, Adriana Puerta, Concepción J González, John M
Published in
Cellular immunology
Chronic infection by Trypanosoma cruzi decreases T cell proliferation and it is most likely accompanied by changes in signals required for activation. We assessed the effect of T. cruzi antigens on mitogen-induced proliferation of T cells from uninfected individuals and the association with the expression of molecules involved in antigen presentati...
