Published in Applied Microbiology and Biotechnology
Abstract Therapeutic options to treat invasive fungal infections are still limited. This makes the development of novel antifungal agents highly desirable. Naturally occurring antifungal peptides represent valid candidates, since they are not harmful for human cells and are endowed with a wide range of activities and their mechanism of action is di...
Published in Egyptian Journal of Biological Pest Control
BackgroundBiological control of insects is the current goal of modern researches to avoid using the harmful chemicals. Some fungi are capable of infecting and killing insects and, hence, are commonly known as entomopathogenic fungi (EPF). On the other hand, some insects can kill harmful fungal strains using their products such as peptides. Hence, t...
Published in Mini reviews in medicinal chemistry
The current trend of increment in the frequency of antifungal resistance has brought research into an era where new antifungal compounds with novel mechanisms of action are required. Natural antimicrobial peptides, which are ubiquitous components of innate immunity, represent their candidature for novel antifungal peptides. Various antifungal pepti...
PAF26 is a synthetic hexapeptide that has been shown to be highly effective at killing filamentous fungi whilst showing low toxicity against human and bacterial cells. Unlike membrane permeabilising antimicrobials, PAF26 at low fungicidal concentrations is endocytically internalised by fungal cells and accumulates in the vacuole, which undergoes ex...
Published in Biochimie
Most antifungal peptides (AFPs), if not all, have membrane activity, while some also have alternative targets. Fungal membranes share many characteristics with mammalian membranes with only a few differences, such as differences in sphingolipids, phosphatidylinositol (PI) content and the main sterol is ergosterol. Fungal membranes are also more neg...
Published in Peptides
Fungi are not classified as plants or animals. They resemble plants in many ways but do not produce chlorophyll or make their own food photosynthetically like plants. Fungi are useful for the production of beer, bread, medicine, etc. More complex than viruses or bacteria; fungi can be destructive human pathogens responsible for various diseases in ...
Published in Peptides
Fungi are not classified as plants or animals. They resemble plants in many ways but do not produce chlorophyll or make their own food photosynthetically like plants. Fungi are useful for the production of beer, bread, medicine, etc. More complex than viruses or bacteria; fungi can be destructive human pathogens responsible for various diseases in ...
Published in Probiotics and Antimicrobial Proteins
Emerging drug resistance varieties and hyper-virulent strains of microorganisms have compelled the scientific fraternity to develop more potent and less harmful therapeutics. Antimicrobial peptides could be one of such therapeutics. This review is an attempt to explore antifungal peptides naturally produced by prokaryotes as well as eukaryotes. The...
Published in Interdisciplinary Sciences: Computational Life Sciences
Chromogranin A (CGA)-N46, a derived peptide of human chromogranin A, has antifungal activity. To further research the active domain of CGA-N46, a series of derivatives were designed by successively deleting amino acid from both terminus of CGA-N46, and the amino acid sequence of each derivative was analyzed by bioinformatic software. Based on the p...
Published in International Journal of Peptide Research and Therapeutics
High throughput screening of antifungal peptide libraries have generated large number of information on peptide activities. However scientists are still struggling to explain the specific antifungal protein motifs resulting in their activities. So a thorough antifungal peptide optimization is required. To design and predict secondary structure of s...
