Vij, Raghav Hube, Bernhard Brunke, Sascha
Published in
Computational and Structural Biotechnology Journal
Many fungi can cause deadly diseases in humans, and nearly every human will suffer from some kind of fungal infection in their lives. Only few antifungals are available, and some of these fail to treat intrinsically resistant species and the ever-increasing number of fungal strains that have acquired resistance. In nature, bacteria and fungi displa...
Soares, Juliana de Jesus Sousa, Nathalie Andrade Azulay-Abulafia, Luna Costa, Rosane Orofino
Abstract Fungal infections by dermatophytes can present with unusual clinical manifestations, which can cause diagnostic difficulties. The authors present the case of a patient with cutaneous infection by Nanizzia gypsea, initially treated erroneously with topical corticosteroids due to a wrong diagnosis. It was cured after antifungal treatment.
Somboon, Pichayada Soontorngun, Nitnipa
Published in
Microbiological research
Multidrug resistance is a highly conserved phenomenon among all living organisms and a major veritable public health problem worldwide. Repetitive uses of antibiotics lead to antimicrobial drug resistance. Here, 19,20-epoxycytochalasin Q (ECQ) was isolated from endophytic fungus Xylaria sp. BCC 1067 and, its chemical structure was determined via ch...
Prusakov, Pavel Goff, Debra A. Wozniak, Phillip S. Cassim, Azraa Scipion, Catherine E.A. Urzúa, Soledad Ronchi, Andrea Zeng, Lingkong Ladipo-Ajayi, Oluwaseun Aviles-Otero, Noelia
...
Published in
EClinicalMedicine
Background Global assessment of antimicrobial agents prescribed to infants in the neonatal intensive care unit (NICU) may inform antimicrobial stewardship efforts. Methods We conducted a one-day global point prevalence study of all antimicrobials provided to NICU infants. Demographic, clinical, and microbiologic data were obtained including NICU le...
Vigasova, Dana Nemergut, Michal Liskova, Barbora Damborsky, Jiri
Published in
Microbial Cell Factories
Alzheimer’s disease (AD) is a chronic neurodegenerative disease associated with the overproduction and accumulation of amyloid-β peptide and hyperphosphorylation of tau proteins in the brain. Despite extensive research on the amyloid-based mechanism of AD pathogenesis, the underlying cause of AD is not fully understood. No disease-modifying therapi...
Sishuba, Anathi Leboko, Jessica Ateba, Collins Njie Manganyi, Madira Coultyne
Published in
Mycobiology
Forty-three ( n = 43) endophytic fungi with different morphologic characteristics were from a medicinal plant Sceletium tortuosum, were utilized to investigate their antifungal effectiveness against pathogenic fungi. All fungal isolates exhibited antifungal activity against one or more pathogens in the dual culture test whereas only 33 fungal cultu...
Kaur, Ranjot Dennison, Sarah R. Burrow, Andrea J. Rudramurthy, Shivaprakash M. Swami, Rajan Gorki, Varun Katare, O. P. Kaushik, Anupama Singh, Bhupinder Singh, Kamalinder K.
...
Published in
Journal of Nanobiotechnology
BackgroundIncidence of pulmonary aspergillosis is rising worldwide, owing to an increased population of immunocompromised patients. Notable potential of the pulmonary route has been witnessed in antifungal delivery due to distinct advantages of direct lung targeting and first-pass evasion. The current research reports biomimetic surface-active lipi...
Klaus, Anita Wan-Mohtar, Wan Abd Al Qadr Imad Nikolić, Biljana Cvetković, Stefana Vunduk, Jovana
Published in
World Journal of Microbiology and Biotechnology
AbstractFour types of mycelial extracts were derived from the airlift liquid fermentation (ALF) of Pleurotus flabellatus, namely exopolysaccharide (EX), endopolysaccharide (EN), hot water (WE), and hot alkali (AE) extracts. Such extracts were screened for their active components and biological potential. EN proved to be most effective in inhibition...
Zhang, Chi Zhao, Jiechang Famous, Erhunmwunsee Pan, Shenyuan Peng, Xue Tian, Jun
Published in
Food chemistry
The essential oil extracted from the black Piper nigrum L. (BPEO) was analyzed for antioxidant, hepatoprotective and antifungal activities. BPEO is rich in total phenolics, total flavonoids and proanthocyanidins, and showed good free radicals and lipid peroxidation scavenging capacities. In a CCl4-induced liver injury mice model, the BPEO treated g...
Khoury, Mitri K Heid, Christopher A Cripps, Michael W Pickett, Maryanne L Nagaraj, Madhuri B Johns, Meagan Lee, Francesca Hennessy, Sara A
Published in
The Journal of surgical research
Necrotizing soft tissue infections (NSTIs) are life-threatening surgical emergencies associated with high morbidity and mortality. Fungal NSTIs are considered rare and have been largely understudied. The purpose of this study was to study the impact of fungal NSTIs and antifungal therapy on mortality after NSTIs. A retrospective chart review was pe...
