Bailly, Christian Vergoten, Gérard
Published in
Natural Products and Bioprospecting
Polyprenylated acylphloroglucinols represent an important class of natural products found in many plants. Among them, the two related products oblongifolin C (Ob-C) and guttiferone K (Gt-K) isolated from Garcinia species (notably from edible fruits), have attracted attention due to their marked anticancer properties. The two compounds only differ b...
Arunmanee, Wanatchaporn Duangkaew, Methawee Taweecheep, Pornchanok Aphicho, Kanokpol Lerdvorasap, Panuwat Pitchayakorn, Jesada Intasuk, Chayada Jiraratmetacon, Runglada Syamsidi, Armini Chanvorachote, Pithi
...
Published in
Computational and Structural Biotechnology Journal
Colicin N (ColN) is a bacteriocin secreted by Escherichia coli ( E. coli ) to kill other Gram-negative bacteria by forcefully generating ion channels in the inner membrane. In addition to its bactericidal activity, ColN have been reported to selectively induce apoptosis in human lung cancer cells via the suppression of integrin modulated survival p...
LEE, JAIHYUNG GONG, YI-XI XIE, DAN-PING JEONG, HYUNJEONG SEO, HOYOUNG KIM, JIHWAN PARK, YANG HO SUN, HU-NAN KWON, TAEHO
Published in
In Vivo
Background/Aim: Asian Traditional medicines are renowned for their antitumor properties and are efficacious in the clinical treatment of various cancer types. ERM210 is a Korean traditional medicine comprising nine types of medicinal plants. In the present study, we examined the pro-apoptotic effect and molecular mechanisms of the effects of ERM210...
Asati, Vivek Anant, Arjun Patel, Preeti Kaur, Kamalpreet Gupta, G D
Published in
European journal of medicinal chemistry
Pyrazolopyrimidine scaffold is one of the privileged heterocycles in drug discovery. This scaffold produced numerous biological activities in which anticancer is important one. Previous studies showed its importance in interactions with various receptors such as growth factor receptor, TGFBR2 gene, CDK2/cyclin E and Abl kinase, adenosine receptor, ...
Soltan, Osama M Shoman, Mai E Abdel-Aziz, Salah A Narumi, Atsushi Konno, Hiroyuki Abdel-Aziz, Mohamed
Published in
European journal of medicinal chemistry
Protein kinases have grown over the past few years as a crucial target for different cancer types. With the multifactorial nature of cancer, and the fast development of drug resistance for conventional chemotherapeutics, a strategy for designing multi-target agents was suggested to potentially increase drug efficacy, minimize side effects and retai...
Khan, A. A. Sirsat, A. T. Singh, H. Cash, P.
Published in
Clinical & Translational Oncology
During last few decades, role of microbiota and its importance in several diseases has been a hot topic for research. The microbiota is considered as an accessory organ for maintaining normal physiology of an individual. These microbiota organisms which normally colonize several epithelial surfaces are known to secrete several small molecules leadi...
Namasivayam, S. Karthick Raja Venkatachalam, Gayathri Bharani, R. S. Arvind Kumar, J. Aravind Sivasubramanian, S.
Published in
3 Biotech
Among the diverse nanomaterials, gold nanoparticles (AuNps) are utilised for various therapeutic application due to the distinct physical, chemical properties and biocompatibility. Synthesis of gold nanoparticles using plants is the promising route. This method is low cost, eco-friendly and higher biological activities. In this present study, Gold ...
Rajan, Durairaj Karthick Mohan, Kannan Zhang, Shubing Ganesan, Abirami Ramu
Published in
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Dieckol [C36H22O18], is a naturally occurring phlorotannin found in some brown algal species. Dieckol is gaining more attention in the scientific community for its potential biological activities. It has been exhibited a broad spectrum of therapeutic functions including anti-bacterial, anti-cancer, anti-oxidant, anti-aging, anti-diabetic, neuroprot...
Nikhitha, J. N. Swathy, K. S. Chandran, R. Pratap
Published in
Journal of Genetic Engineering and Biotechnology
BackgroundOvarian cancer causes more deaths than any other cancer of the female reproductive system because there is no effective screening and most women are diagnosed at advanced stages. The probability of survival at 5 years is less than 30%, and the limitation is that it will not respond to chemotherapy protocol and surgery as well. Moreover, s...
Alanazi, Mohammed M. Eissa, Ibrahim H. Alsaif, Nawaf A. Obaidullah, Ahmad J. Alanazi, Wael A. Alasmari, Abdullah F. Albassam, Hussam Elkady, Hazem Elwan, Alaa
Published in
Journal of Enzyme Inhibition and Medicinal Chemistry
Vascular endothelial growth factor receptor-2 (VEGFR-2) plays a critical role in cancer angiogenesis. Inhibition of VEGFR-2 activity proved effective suppression of tumour propagation. Accordingly, two series of new 3-methylquinoxaline derivatives have been designed and synthesised as VEGFR-2 inhibitors. The synthesised derivatives were evaluated i...
