Blengio, Fabiola Hocini, Hakim Richert, Laura Lefebvre, Cécile Durand, Melany Hejblum, Boris P. Tisserand, Pascaline Mclean, Chelsea Luhn, Kerstin Thiébaut, Rodolphe
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Ebola virus disease is a severe hemorrhagic fever with a high fatality rate. We investigate transcriptome profiles at 3 h, 1 day, and 7 days after vaccination with Ad26.ZEBOV and MVA-BN-Filo. 3 h after Ad26.ZEBOV injection, we observe an increase in genes related to antigen presentation, sensing, and T and B cell receptors. The highest response occ...
Asashima, Hiromitsu Kim, Dongjoo Wang, Kaicheng Lele, Nikhil Buitrago-Pocasangre, Nicholas Lutz, Rachel Cruz, Isabella Raddassi, Khadir Ruff, William Racke, Michael
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BACKGROUNDWhile B cell depletion is associated with attenuated antibody responses to SARS-CoV-2 mRNA vaccination, responses vary among individuals. Thus, elucidating the factors that affect immune responses after repeated vaccination is an important clinical need.METHODSWe evaluated the quality and magnitude of the T cell, B cell, antibody, and cyt...
Kastenschmidt, Jenna Sureshchandra, Suhas Jain, Aarti Hernandez-Davies, Jenny de Assis, Rafael Wagoner, Zachary Sorn, Andrew Mitul, Mahina Benchorin, Aviv Levendosky, Elizabeth
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Highly effective vaccines elicit specific, robust, and durable adaptive immune responses. To advance informed vaccine design, it is critical that we understand the cellular dynamics underlying responses to different antigen formats. Here, we sought to understand how antigen-specific B and T cells were activated and participated in adaptive immune r...
Rivera, Carlos E Zhou, Yulai Chupp, Daniel P Yan, Hui Fisher, Amanda D Simon, Raphael Zan, Hong Xu, Zhenming Casali, Paolo
Maturation of antibody responses entails somatic hypermutation (SHM), class-switch DNA recombination (CSR), plasma cell differentiation, and generation of memory B cells, and it is thought to require T cell help. We showed that B cell Toll-like receptor 4 (TLR4)-B cell receptor (BCR) (receptor for antigen) coengagement by 4-hydroxy-3-nitrophenyl ac...
Brewer, R Lanz, Tobias Hale, Caryn Sepich-Poore, Gregory Martino, Cameron Swafford, Austin Carroll, Thomas Kongpachith, Sarah Blum, Lisa Elliott, Serra
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Periodontal disease is more common in individuals with rheumatoid arthritis (RA) who have detectable anti-citrullinated protein antibodies (ACPAs), implicating oral mucosal inflammation in RA pathogenesis. Here, we performed paired analysis of human and bacterial transcriptomics in longitudinal blood samples from RA patients. We found that patients...
Badten, Alexander J Ramirez, Aaron Hernandez-Davies, Jenny E Albin, Tyler J Jain, Aarti Nakajima, Rie Felgner, Jiin Davies, D Huw Wang, Szu-Wen
The vast majority of seasonal influenza vaccines administered each year are derived from virus propagated in eggs using technology that has changed little since the 1930s. The immunogenicity, durability, and breadth of response would likely benefit from a recombinant nanoparticle-based approach. Although the E2 protein nanoparticle (NP) platform ha...
Crane, Clarkson Phebus, Erin Ingulli, Elizabeth
BackgroundAdditional "booster" doses of mRNA SARS-CoV-2 vaccines have become standard of care for immunosuppressed patients, including kidney transplant recipients (KTR). While these additional doses have been shown to be efficacious in the adult KTR population, there is paucity of data for pediatric and adolescent KTR.MethodsWe conducted a retrosp...
Li, Lili Gao, Meiling Li, Jie Xie, Xuping Zhao, Hui Wang, Yanan Xu, Xin Zu, Shulong Chen, Chunfeng Wan, Dingyi
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BackgroundSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of the global coronavirus disease 2019 (COVID-19) pandemic, contains a unique, four amino acid (aa) "PRRA" insertion in the spike (S) protein that creates a transmembrane protease serine 2 (TMPRSS2)/furin cleavage site and enhances viral infectivity. More re...
Cook, L O'dell, G Vourvou, E Palanicawandar, R Marks, S Milojkovic, D Apperley, J Loaiza, S Claudiani, S Bua, M
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SARS-CoV-2 infection, and resulting disease, COVID-19, has a high mortality amongst patients with haematological malignancies. Global vaccine rollouts have reduced hospitalisations and deaths, but vaccine efficacy in patients with haematological malignancies is known to be reduced. The UK-strategy offered a third, mRNA-based, vaccine as an extensio...
Tashi, Tenzin Upadhye, Aditi Kundu, Prasun Wu, Chunxiang Menant, Sébastien Soares, Roberta Reis Ferreira, Marcelo U Longley, Rhea J Mueller, Ivo Hoang, Quyen Q
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Funder: CAPES doctoral fellowship / Funder: Michael J. Fox Foundation / Funder: CNPq senior research fellowship / BACKGROUND: To make progress towards malaria elimination, a highly effective vaccine targeting Plasmodium vivax is urgently needed. Evaluating the kinetics of natural antibody responses to vaccine candidate antigens after acute vivax ma...
