Antineutrophil cytoplasmic antibodies and their association with clinical outcomes in hospitalized COVID-19 patients
Published in Cell Death Discovery
Characterization of humoral and SARS-CoV-2 specific T cell responses in people living with HIV
...Published in Nature Communications
Understanding the pathology and immunological response to SARS CoV2 infection in specific patient groups is essential for informing the scientific and clinical handling of infections within these patient populations. Here the authors characterise the adaptive immune response to SARS-CoV2 infection in people living with HIV.
Afucosylated Plasmodium falciparum -specific IgG is induced by infection but not by subunit vaccination
...Published in Nature Communications
Here, Larsen et al. describe differences in Fc fucosylation of P. falciparum PfEMP1-specific IgG produced in response to natural infection versus VAR2CSA-type subunit vaccination, which leads to differences in the ability to induce FcγRIIIa-dependent natural killer cell degranulation.
Increased lethality in influenza and SARS-CoV-2 coinfection is prevented by influenza immunity but not SARS-CoV-2 immuni...
...Published in Nature Communications
Influenza A virus (IAV) and SARS-CoV-2 coinfection is a possible scenario during influenza season. Here, the authors show in a mouse model that IAV infection increases the risk of severe disease upon SARS-CoV-2 infection two days later. IAV vaccination, especially antibody-dependent, protects from severe disease during coinfection.
COVID-19 mRNA vaccine and antibody response in lactating women: a prospective cohort study
Published in BMC Pregnancy and Childbirth
Background Immunological protection via breastfeeding is well known. The immunological profile of human milk changes during lactation. No clinical trials have been conducted in lactating women with the newest mRNA vaccines against SARS- CoV-2. A Few studies have shown the presence of antibodies in breastmilk after vaccination. The aim of this work ...
Influence of IL-6 levels on patient survival in COVID-19
...Published in Journal of Critical Care
Early immunologic response to mRNA COVID-19 vaccine in patients receiving biologics and/or immunomodulators
Published in medRxiv
Patients with immune conditions and immune-modifying therapies were excluded from the Covid-19 vaccine trials. Studies have shown conflicting response to different vaccines in persons receiving immune suppressors or biologics. The aim of this study is to evaluate humoral and cellular response to Covid-19 vaccines in patients with Inflammatory Bowel...
Recombinant antigens used as diagnostic tools for lymphatic filariasis
Published in Parasites & Vectors
Lymphatic filariasis (LF) is a parasitic disease caused by the worms Wuchereria bancrofti , Brugia malayi , or Brugia timori . It is a tropical and subtropical illness that affects approximately 67 million people worldwide and that still requires better diagnostic tools to prevent its spread and enhance the effectiveness of control procedures. Trad...
SARS-CoV-2 seroprevalence among 7950 healthcare workers in the Region of Southern Denmark
Published in International Journal of Infectious Diseases
Objective Healthcare workers (HCWs) carry a pronounced risk of acquiring severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. The aim of this study was to determine the seroprevalence and potential risk factors of SARS-CoV-2 infection among HCWs in the Region of Southern Denmark after the first pandemic wave in the spring of 2020...
New-onset IgG autoantibodies in hospitalized patients with COVID-19
...Published in Nature Communications
Infection with SARS-CoV2 and the development of Coronavirus disease 2019 (COVID-19) has been linked to induction of autoimmunity and autoantibody production. Here the authors characterise the new-onset IgG autoantibody response in hospitalised patients with COVID-19 which they correlate to the magnitude of the SARS-CoV2 response.
