CAVALCANTE, Larissa Maria RAMOS, Amanda Barreto SILVA, Daniela Costa ALVES, Gutemberg Gomes ANTUNES, Karinne Bueno PFEIFER, Carmem Silvia SCHNEIDER, Luis Felipe Jochims
Abstract This study determined the effect of thiourethane-functionalized fillers (TU) on the antimicrobial properties, cytotoxicity, degree of conversion (DC), water sorption (Wsp) and solubility (Wsl) of experimental composites. TU-modified fillers were added at different ratios in experimental composites: 0 (Control-TU0), 25% (TU25), 50% (TU50), ...
Wang, Xiaokang Rai, Navneet Merchel Piovesan Pereira, Beatriz Eetemadi, Ameen Tagkopoulos, Ilias
How to design experiments that accelerate knowledge discovery on complex biological landscapes remains a tantalizing question. We present an optimal experimental design method (coined OPEX) to identify informative omics experiments using machine learning models for both experimental space exploration and model training. OPEX-guided exploration of E...
Evans, Stephen J Roberts, Aled EL Morris, Andrew Conway Simpson, A John Harris, Llinos G Mack, Dietrich Jenkins, Rowena E Wilkinson, Thomas S
David, Sophia Cohen, Victoria Reuter, Sandra Sheppard, Anna E Giani, Tommaso Parkhill, Julian Rossolini, Gian Maria Feil, Edward J Grundmann, Hajo Aanensen, David M
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O'Brien, Kieran S Arzika, Ahmed M Maliki, Ramatou Manzo, Farouk Mamkara, Alio K Lebas, Elodie Cook, Catherine Bailey, Robin L West, Sheila K Oldenburg, Catherine E
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BACKGROUND:Biannual azithromycin distribution has been shown to reduce child mortality as well as increase antimicrobial resistance. Targeting distributions to vulnerable subgroups such as malnourished children is one approach to reaching those at the highest risk of mortality while limiting selection for resistance. The objective of this analysis ...
Zhao, Decai Yang, Nailiang Wei, Yan Jin, Quan Wang, Yanlei He, Hongyan Yang, Yang Han, Bing Zhang, Suojiang Wang, Dan
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Hollow multishelled structures (HoMSs), with relatively isolated cavities and hierarchal pores in the shells, are structurally similar to cells. Functionally inspired by the different transmission forms in living cells, we studied the mass transport process in HoMSs in detail. In the present work, after introducing the antibacterial agent methyliso...
Hart, John D Samikwa, Lyson Sikina, Feston Kalua, Khumbo Keenan, Jeremy D Lietman, Thomas M Burr, Sarah E Bailey, Robin L
Reductions in malaria morbidity have been reported following azithromycin mass drug administration (MDA) for trachoma. The recent Macrolides Oraux pour Reduire les Deces avec un Oeil sur la Resistance (MORDOR) trial reported a reduction in child mortality following biannual azithromycin MDA. Here, we investigate the effects of azithromycin MDA on m...
Bloch, Evan M Munoz, Beatriz Weaver, Jerusha Mrango, Zakayo Lietman, Thomas M West, Sheila K
A cluster-randomized clinical trial showed that biannual single-dose azithromycin reduced mortality in preschool children; we sought to determine the effect on anemia. A simple random sample of 30 communities from Kilosa district, Tanzania, were themselves randomized to receive either 6-monthly treatment of children aged 1-59 months with single-dos...
Hart, John D Kalua, Khumbo Keenan, Jeremy D Lietman, Thomas M Bailey, Robin L
Recent evidence indicates mass drug administration with azithromycin may reduce child mortality. This study uses verbal autopsy (VA) to investigate the causes of individual deaths during the Macrolides Oraux pour Réduire les Décès avec un Oeil sur la Résistance (MORDOR) trial in Malawi. Cluster randomization was performed as part of MORDOR. Biannua...
Sumpter, Colin Russell, Clark D. Mackintosh, Claire
Published in
International Journal for Equity in Health
Study aimTo assess whether Outpatient Parenteral Antimicrobial Therapy (OPAT) is provided equitably across gender and social groups in a tertiary care setting.BackgroundOPAT is a widely used and growing approach in high income countries to early discharge or admission avoidance for patients requiring intravenous antimicrobials. There is however a r...