Objectives We sought to determine the prevalence of asymptomatic bacteriuria (ASB) in patients with sickle cell disease (SCD), the susceptibility profile of its agents and their extended-spectrum β-lactamase (ESBL) production. Methods Fifty-nine patients with SCD and 116 healthy controls were investigated. Urine samples were collected and cultured ...
Objectives We investigated associations between full Electronic Medical Record (EMR) system adoption and drug use in healthcare organizations (HCOs) to explore whether EMR system features such as electronic prescribing, medicines reconciliation, and decision support, might be related to drug use by using the relevant nation-wide data. Methods The s...
Background: Urinary tract infections are considered as one of the most frequent bacterial infections in the community and hospital settings. In this era of increasing antimicrobial resistance, antimicrobial stewardship has become highly important in the struggle to preserve the effectiveness of available drugs. One the main causes of antibiotic res...
Objective - The functional role of interleukin-22 (IL22) in chronic inflammation is controversial and mechanistic insights into how it regulates target tissue are lacking. In this study, we evaluated the functional role of IL22 in chronic colitis and probed mechanisms of IL22- mediated regulation of colonic epithelial cells. Design – To investigate...
Kime, LouiseRandall, Christopher PBanda, Frank IColl, FrancescWright, JohnRichardson, JosephEmpel, JoannaParkhill, JulianO'Neill, Alex J
Sporadic literature reports describe isolates of pathogenic bacteria that harbor an antibiotic resistance determinant but remain susceptible to the corresponding antibiotic as a consequence of a genetic defect. Such strains represent a source from which antibiotic resistance may reemerge to cause treatment failure in patients. Here, we report a sys...
