Tseng, Yeu-Yang Liao, Guan-Ru Lien, Abigail Hsu, Wei-Li
Published in
Computational and Structural Biotechnology Journal
The coronavirus (CoV) infects a broad range of hosts including humans as well as a variety of animals. It has gained overwhelming concerns since the emergence of deadly human coronaviruses (HCoVs), severe acute respiratory syndrome coronavirus (SARS-CoV) in 2003, followed by Middle East respiratory syndrome coronavirus (MERS-CoV) in 2015. Very rece...
Balachandran, Subin Binitha, R. N.
Published in
In Silico Pharmacology
Antioxidant food additives were routinely used for increasing the keeping quality of packaged food items. Butylated Hydroxyanisole (BHA) is one of the most widely used synthetic phenolic antioxidants of such kind. Although quantity of antioxidants in packaged eatables and admissible daily intake (ADI) per person per day are limited by laws, the urb...
Neumann, Susanne Krieger, Christine C. Gershengorn, Marvin C.
Published in
European Thyroid Journal
Graves’ disease (GD) is an autoimmune disease caused in part by thyroid-stimulating antibodies (TSAbs) that activate the thyroid-stimulating hormone receptor (TSHR). In Graves’ hyperthyroidism (GH), TSAbs cause persistent stimulation of thyroid cells leading to continuous thyroid hormone synthesis and secretion. Thyroid eye disease (TED), also call...
Alazzouni, Ahmed S. Abdel Aziz, Elsayed A. Elnabtity, Sameh Salem, Areej I.
Published in
The Journal of Basic and Applied Zoology
BackgroundPeptic ulcer is an excoriated area of stomach or intestinal mucosa. Two experimental designs were proceeded: the first aimed. on twenty adult male albino rats, used to study the protective effect of both ranitidine and nizatidine; on the second, including sixty adult male albino rats, was used to study the therapeutic effect of ranitidine...
Tiwari, Vaibhav Tandon, Ritesh Sankaranarayanan, Nehru Viji Beer, Jacob C. Kohlmeir, Ellen K. Swanson-Mungerson, Michelle Desai, Umesh R.
Published in
bioRxiv
The COVID-19 pandemic caused by SARS-CoV-2 is in immediate need of an effective antidote. Although the Spike glycoprotein (SgP) of SARS-CoV-2 has been shown to bind to heparins, the structural features of this interaction, the role of a plausible heparan sulfate proteoglycan (HSPG) receptor, and the antagonism of this pathway through small molecule...
Kariuki, Caroline K. Mutitu, Eunice W. Muiru, William M.
Published in
Egyptian Journal of Biological Pest Control
BackgroundBacterial wilt caused by Ralstonia solanacearum is one of the most devastating diseases in tomato cultivation. This study aimed to evaluate the effect of Bacillus and Trichoderma isolates to manage the bacterial wilt disease.Main body of the abstractField experiments were conducted in a randomized complete block design at Mwea and Kabete ...
Zhang, Han He, Xiaomeng Wang, Xintong Yu, Bo Zhao, Siqi Jiao, Peili Jin, Hongwei Liu, Zhenming Wang, KeWei Zhang, Liangren
...
Published in
European journal of medicinal chemistry
α: 7 nicotinic acetylcholine receptors (nAChRs) expressed in the nervous and immune systems have been suggested to play important roles in the control of inflammation. However, the lack of antagonist tools specifically inhibiting α7 nAChR impedes the validation of the channel as therapeutic target. To discover a selective α7 antagonist, we started ...
Zhang, Wen-Jun Zhu, Zheng-Ming Liu, Zeng-Xu
Published in
Pharmacological research
Neuropathic pain (NPP) is a common symptom of most diseases in clinic, which seriously affects the mental health of patients and brings certain pain to patients. Due to its pathological mechanism is very complicated, and thus, its treatment has been one of the challenges in the field of medicine. Therefore, exploring the pathogenesis and treatment ...
Messiha, N. A. S. Elhalag, K. M. A. Balabel, N. M. Farag, S. M. A. Matar, H. A. Hagag, M. H. Khairy, A. M. El-Aliem, M. M. Abd Eleiwa, E. Saleh, O. M. E.
...
Published in
Egyptian Journal of Biological Pest Control
Potato brown rot, caused by Ralstonia solanacearum, ranked globally as the second most important bacterial plant pathogen. In the present study, the influence of different cropping programs in potato brown rot management was investigated in four infected fields in Egypt. Two districts were selected as sandy soils in Giza (Wardan) and Behera (Ganuob...
Attah, Isaac Y Neumann, Alexander Al-Hroub, Haneen Rafehi, Muhammad Baqi, Younis Namasivayam, Vigneshwaran Müller, Christa E
Published in
Biochimica et biophysica acta. General subjects
The nucleotide receptors P2Y2 and P2Y4 are the most closely related G protein-coupled receptors (GPCRs) of the P2Y receptor (P2YR) family. Both subtypes couple to Gq proteins and are activated by the pyrimidine nucleotide UTP, but only P2Y2R is also activated by the purine nucleotide ATP. Agonists and antagonists of both receptor subtypes have pote...
