Alazzouni, Ahmed S. Abdel Aziz, Elsayed A. Elnabtity, Sameh Salem, Areej I.
Published in
The Journal of Basic and Applied Zoology
BackgroundPeptic ulcer is an excoriated area of stomach or intestinal mucosa. Two experimental designs were proceeded: the first aimed. on twenty adult male albino rats, used to study the protective effect of both ranitidine and nizatidine; on the second, including sixty adult male albino rats, was used to study the therapeutic effect of ranitidine...
Tiwari, Vaibhav Tandon, Ritesh Sankaranarayanan, Nehru Viji Beer, Jacob C. Kohlmeir, Ellen K. Swanson-Mungerson, Michelle Desai, Umesh R.
Published in
bioRxiv
The COVID-19 pandemic caused by SARS-CoV-2 is in immediate need of an effective antidote. Although the Spike glycoprotein (SgP) of SARS-CoV-2 has been shown to bind to heparins, the structural features of this interaction, the role of a plausible heparan sulfate proteoglycan (HSPG) receptor, and the antagonism of this pathway through small molecule...
Kariuki, Caroline K. Mutitu, Eunice W. Muiru, William M.
Published in
Egyptian Journal of Biological Pest Control
BackgroundBacterial wilt caused by Ralstonia solanacearum is one of the most devastating diseases in tomato cultivation. This study aimed to evaluate the effect of Bacillus and Trichoderma isolates to manage the bacterial wilt disease.Main body of the abstractField experiments were conducted in a randomized complete block design at Mwea and Kabete ...
Zhang, Han He, Xiaomeng Wang, Xintong Yu, Bo Zhao, Siqi Jiao, Peili Jin, Hongwei Liu, Zhenming Wang, KeWei Zhang, Liangren
...
Published in
European journal of medicinal chemistry
α: 7 nicotinic acetylcholine receptors (nAChRs) expressed in the nervous and immune systems have been suggested to play important roles in the control of inflammation. However, the lack of antagonist tools specifically inhibiting α7 nAChR impedes the validation of the channel as therapeutic target. To discover a selective α7 antagonist, we started ...
Messiha, N. A. S. Elhalag, K. M. A. Balabel, N. M. Farag, S. M. A. Matar, H. A. Hagag, M. H. Khairy, A. M. El-Aliem, M. M. Abd Eleiwa, E. Saleh, O. M. E.
...
Published in
Egyptian Journal of Biological Pest Control
Potato brown rot, caused by Ralstonia solanacearum, ranked globally as the second most important bacterial plant pathogen. In the present study, the influence of different cropping programs in potato brown rot management was investigated in four infected fields in Egypt. Two districts were selected as sandy soils in Giza (Wardan) and Behera (Ganuob...
Attah, Isaac Y Neumann, Alexander Al-Hroub, Haneen Rafehi, Muhammad Baqi, Younis Namasivayam, Vigneshwaran Müller, Christa E
Published in
Biochimica et biophysica acta. General subjects
The nucleotide receptors P2Y2 and P2Y4 are the most closely related G protein-coupled receptors (GPCRs) of the P2Y receptor (P2YR) family. Both subtypes couple to Gq proteins and are activated by the pyrimidine nucleotide UTP, but only P2Y2R is also activated by the purine nucleotide ATP. Agonists and antagonists of both receptor subtypes have pote...
Li, Jun-Xu
Published in
Neuropharmacology
Pain remains a global health challenge. For decades, clinicians have been primarily relying on μ-opioid receptor (MOR) agonists and nonsteroidal anti-inflammatory drugs (NSAIDs) for pain management. MOR agonists remain the most efficacious analgesics available; however, adverse effects related to MOR agonists use are severe which often lead to forc...
Zhang, Ying-Ying Yu, Ying Yu, Chen
Published in
Renal Fibrosis: Mechanisms and Therapies
The rennin–angiotensin–aldosterone system (RAAS) has been well documented in regulating blood pressure, fluid volume, and sodium balance. Overactivity of RAAS promotes both systemic and regional glomerular capillary hypertension, which could induce hemodynamic injury to the glomerulus, leading to kidney damage and renal fibrosis via profibrotic and...
Dudoignon, Emmanuel Dépret, François Legrand, Matthieu
Published in
Nephron
The renin-angiotensin-aldosterone system (RAAS) plays a major role in the regulation of blood pressure, renal hemodynamic, myocardial contractility via an enzymatic cascade leading to the synthesis of angiotensin 2. The activation of the RAAS system after acute kidney injury triggers renal inflammation and fibrotic process with long-term damaging c...
de Tenório, Dyana A. de Medeiros, Erika Valente Lima, Cristiano S. da Silva, Jéssica M. de Barros, Jamilly A. Neves, Rejane P. Laranjeira, Delson
Published in
Tropical Plant Pathology
Yeasts have been used to manage a large number of plant diseases, but little is known about the mechanisms used by these biocontrol agents. The objectives of the present study were to evaluate the antagonistic effect of yeasts against Rhizoctonia solani and possible mechanisms of action in cowpea plants. Seventy yeast isolates were obtained from le...
