Azevedo Loiola, Rodrigo Hachani, Johan Duban-Deweer, Sophie Sevin, Emmanuel Bugno, Paulina Kowalska, Agnieszka Rizzi, Eleonora Shimizu, Fumitaka Kanda, Takashi Mysiorek, Caroline
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Cell-based therapeutic strategies have been proposed as an alternative for brain and blood vessels repair after stroke, but their clinical application is hampered by potential adverse effects. We therefore tested the hypothesis that secretome of these cells might be used instead to still focus on cell-based therapeutic strategies. We therefore char...
Published in
Molecular neurobiology
Ischemic stroke (IS) stands as a prominent cause of mortality and long-term disability around the world. It arises primarily from a disruption in cerebral blood flow, inflicting severe neural injuries. Hence, there is a pressing need to comprehensively understand the intricate mechanisms underlying IS and identify novel therapeutic targets. Recentl...
Elseweidy, Mohamed M Ali, Sousou I Shaheen, Mohamed A Abdelghafour, Asmaa M Hammad, Sally K
Published in
Naunyn-Schmiedeberg's archives of pharmacology
Ischemic heart diseases such as myocardial infarction (MI) are a global health problem and a leading cause of mortality worldwide. Angiogenesis is an important approach for myocardial healing following ischemia. Thus, this study aimed to explore the potential cardiac angiogenic effects of selenium (Se), alone and in combination with the tumor necro...
Naffrichoux, Jeremie Poupin, Pierre Pouillot, William Linassier, Claude Rioux-Leclercq, Nathalie de Vries-Brilland, Manon Mourey, Loïc Laguerre, Brigitte Oudard, Stéphane Gross‐goupil, Marine
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Introduction: Papillary renal cell carcinoma (pRCC) is a rare and aggressive cancer with no specifically established therapeutic strategy in the metastatic setting. Combinations of tyrosine kinase and immune checkpoint inhibitors (ICI) are a promising option. We aimed to study the immune landscape of metastatic pRCC, and its interactions with angio...
Cohn, Kendyl
This research developed methods for culturing self-assembling capillaries in an injectable gel as a potential method for vascularizing tissue-on-a-chip models to mimic physiological drug delivery. Additionally, a mathematical model was developed as a tool for understanding nutrient delivery and comparison of potential delivery systems. Organs-on-a-...
Krog, M C Flachs, E M Kolte, A M de Jager, W Meyaard, L Christiansen, O B Steffensen, R Vomstein, K Garred, P Nielsen, H S
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Published in
Journal of reproductive immunology
The poor remodeling of placental spiral arteries seen in preeclampsia is also discussed to contribute to recurrent pregnancy loss (RPL) preceded by abnormal angiogenesis and excessive complement activation. Low levels of Mannose-binding-lectin (MBL), a pattern recognition molecule (PRM) of the lectin pathway, have been found in women with RPL. We p...
Mirza, Sarah L Upton, Paul D Hodgson, Joshua Gräf, Stefan Morrell, Nicholas W Dunmore, Benjamin J
AIMS: Bone morphogenetic protein-9 (BMP9) is critical for bone morphogenetic protein receptor type-2 (BMPR2) signalling in pulmonary vascular endothelial cells. Furthermore, human genetics studies support the central role of disrupted BMPR2 mediated BMP9 signalling in vascular endothelial cells in the initiation of pulmonary arterial hypertension (...
Chung, Seyong Sung, Hak-Joon
Published in
Pulse
Background: Enhanced regenerative therapeutic strategies are required to treat intractable ischemic heart disease. Summary: Since the discovery of putative endothelial progenitor cells (EPCs) in 1997, many studies have focused on their extraction, ex vivo processing, and autotransplantation under ischemic conditions. Nonetheless, numerous randomize...
Buth, Jessie Dyevich, Catherine Rubin, Alexandra Wang, Chengbing Gao, Lei Marks, Tessa Harrison, Michael Kong, Jennifer Ross, M Novitch, Bennett
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Neural progenitor cells within the cerebral cortex undergo a characteristic switch between symmetric self-renewing cell divisions early in development and asymmetric neurogenic divisions later. Yet, the mechanisms controlling this transition remain unclear. Previous work has shown that early but not late neural progenitor cells (NPCs) endogenously ...
Pinto, Elisa Pelizzaro, Filippo Cardin, Romilda Battistel, Michele Palano, Giorgio Bertellini, Federica Kitenge, Maria Piera Peserico, Giulia Farinati, Fabio Russo, Francesco Paolo
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Published in
Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver
Neoangiogenesis plays a crucial role in the progression of hepatocellular carcinoma (HCC), and concerns have been raised about the role of neoangiogenesis on the effectiveness of transarterial chemoembolization (TACE). In this study, we aimed to evaluate Vascular Endothelial Growth Factor (VEGF) and Hypoxia-Inducible Factor-1α (HIF-1α) as circulati...
