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Nagata, Yusuke Kato, Ken Miyamoto, Takahiro Hirano, Hidekazu Shoji, Hirokazu Iwasa, Satoru Honma, Yoshitaka Takashima, Atsuo Hamaguchi, Tetsuya Matsushita, Hiromichi
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Published in
Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer
Gastrointestinal cancer is frequently associated with malignant ascites, resulting in poor prognosis. While cell-free and concentrated ascites reinfusion therapy (CART) improves ascites-related symptoms, its clinical impact in combination with systemic chemotherapy is unclear. The purpose of this study was to evaluate the safety and efficacy of CAR...
Chen, Ju Ye, Xiaoyang Pitmon, Elise Lu, Mengqian Wan, Jun Jellison, Evan R. Adler, Adam J. Vella, Anthony T. Wang, Kepeng
Published in
Journal for ImmunoTherapy of Cancer
BackgroundThe IL-17 family cytokines are potent drivers of colorectal cancer (CRC) development. We and others have shown that IL-17 mainly signals to tumor cells to promote CRC, but the underlying mechanism remains unclear. IL-17 also dampens Th1-armed anti-tumor immunity, in part by attracting myeloid cells to tumor. Whether IL-17 controls the act...
