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Total serum bilirubin exceeding exchange transfusion thresholds in the setting of universal screening.

Published in The Journal of pediatrics

To describe the incidence and predictors of total serum bilirubin (TSB) levels that meet or exceed American Academy of Pediatrics (AAP) exchange transfusion (ET) thresholds in the setting of universal screening. We conducted a retrospective cohort analysis of electronic data on 18 089 newborns ≥35 weeks gestation born at Northern California Kaiser ...

Impact of Universal Bilirubin Screening on Severe Hyperbilirubinemia and Phototherapy Use

Published in PEDIATRICS

The goal was to assess the impact of universal bilirubin screening on severe hyperbilirubinemia and phototherapy use. In this retrospective cohort study of 358086 infants of > or =35 weeks and > or =2000 g born between January 1, 1995, and June 30, 2007, we obtained demographic data, bilirubin levels, and codes for inpatient phototherapy from exist...

Numbers Needed to Treat With Phototherapy According to American Academy of Pediatrics Guidelines

Published in PEDIATRICS

Our aims were to estimate the efficacy of hospital phototherapy for neonatal jaundice and the number needed to treat to prevent one infant from reaching the exchange transfusion level. From a cohort of 281 898 infants weighing > or =2000 g born at > or =35 weeks' gestation at 12 Northern California Kaiser hospitals from 1995 to 2004, we identified ...

Recurrent Wheezing in the Third Year of Life Among Children Born at 32 Weeks' Gestation or Later

Published in Archives of Pediatrics and Adolescent Medicine

To quantify the relationship between recurrent wheezing (RW) in the third year of life and respiratory syncytial virus (RSV) infection, prematurity, and neonatal oxygen exposure. Retrospective cohort study linking inpatient, outpatient, and laboratory databases for cohort assembly and logistic regression analysis. Integrated health care delivery sy...

Follow-up of extreme neonatal hyperbilirubinaemia: more reassuring results from Denmark

Published in Developmental Medicine & Child Neurology

Incidence, Etiology, and Outcomes of Hazardous Hyperbilirubinemia in Newborns

Published in PEDIATRICS

Total serum bilirubin (TSB) levels ≥ 30 mg/dL are rare but potentially hazardous. A better understanding of their incidence, causes, and outcomes could help inform preventive efforts. We identified infants born ≥ 35 weeks' gestational age from 1995-2011 in Kaiser Permanente Northern California (n = 525409) and examined the medical records of infant...

Neonatal Neurocritical Care Service Is Associated With Decreased Administration of Seizure Medication

Published in Journal of Child Neurology

This cohort study examines medication use in term neonates with hypoxic-ischemic encephalopathy and seizures before and after implementation of a Neonatal Neurocritical Care Service (N = 108), which included increased seizure monitoring. Nearly all neonates received phenobarbital (96% pre- vs 95% post-Neonatal Neurocritical Care Service) and total ...

Stratification of Risk of Early-Onset Sepsis in Newborns >=34 Weeks' Gestation

Published in PEDIATRICS

To define a quantitative stratification algorithm for the risk of early-onset sepsis (EOS) in newborns ≥ 34 weeks' gestation. We conducted a retrospective nested case-control study that used split validation. Data collected on each infant included sepsis risk at birth based on objective maternal factors, demographics, specific clinical milestones, ...

Effect of Neonatal Jaundice and Phototherapy on the Frequency of First-Year Outpatient Visits

Published in PEDIATRICS

The objective of this study was to determine whether either hyperbilirubinemia or inpatient phototherapy is associated with increased subsequent outpatient visit rates, a possible effect of the "vulnerable child syndrome." We compared 3 groups of otherwise well term and late-preterm infants who were born between 1995 and 2004 in Northern California...