Gaubert, Malo Lange, Catharina Garnier-Crussard, Antoine Köbe, Theresa Bougacha, Salma Gonneaud, Julie de Flores, Robin Tomadesso, Clémence Mézenge, Florence Landeau, Brigitte
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Published in
Alzheimer's Research & Therapy
BackgroundWhite matter hyperintensities (WMH) are frequently found in Alzheimer’s disease (AD). Commonly considered as a marker of cerebrovascular disease, regional WMH may be related to pathological hallmarks of AD, including beta-amyloid (Aβ) plaques and neurodegeneration. The aim of this study was to examine the regional distribution of WMH asso...
Desale, Smita Eknath Chidambaram, Hariharakrishnan Chinnathambi, Subashchandrabose
Published in
Molecular Biomedicine
Alzheimer’s disease is a progressive neurodegenerative disease characterized by the presence of amyloid-β plaques in the extracellular environment and aggregates of Tau protein that forms neurofibrillary tangles (NFTs) in neuronal cells. Along with these pathological proteins, the disease shows neuroinflammation, neuronal death, impairment in the i...
Zhou, Yadi Xu, Jielin Hou, Yuan Leverenz, James B. Kallianpur, Asha Mehra, Reena Liu, Yunlong Yu, Haiyuan Pieper, Andrew A. Jehi, Lara
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Published in
Alzheimer's Research & Therapy
BackgroundDementia-like cognitive impairment is an increasingly reported complication of SARS-CoV-2 infection. However, the underlying mechanisms responsible for this complication remain unclear. A better understanding of causative processes by which COVID-19 may lead to cognitive impairment is essential for developing preventive and therapeutic in...
Lodder, Chritica Scheyltjens, Isabelle Stancu, Ilie Cosmin Botella Lucena, Pablo Gutiérrez de Ravé, Manuel Vanherle, Sarah Vanmierlo, Tim Cremers, Niels Vanrusselt, Hannah Brône, Bert
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Published in
Acta Neuropathologica Communications
Alzheimer's disease (AD) is characterized by a sequential progression of amyloid plaques (A), neurofibrillary tangles (T) and neurodegeneration (N), constituting ATN pathology. While microglia are considered key contributors to AD pathogenesis, their contribution in the combined presence of ATN pathologies remains incompletely understood. As sensor...
Chen, Yaojing Dang, Mingxi Zhang, Zhanjun
Published in
Molecular Neurodegeneration
Neuropsychiatric symptoms (NPSs) are common in patients with Alzheimer’s disease (AD) and are associated with accelerated cognitive impairment and earlier deaths. This review aims to explore the neural pathogenesis of NPSs in AD and its association with the progression of AD. We first provide a literature overview on the onset times of NPSs. Differ...
Xia, Yuxing Prokop, Stefan Giasson, Benoit I.
Published in
Molecular Neurodegeneration
Phosphorylation is one of the most prevalent post-translational modifications found in aggregated tau isolated from Alzheimer’s disease (AD) patient brains. In tauopathies like AD, increased phosphorylation or hyperphosphorylation can contribute to microtubule dysfunction and is associated with tau aggregation. In this review, we provide an overvie...
Rostami, Jinar Mothes, Tobias Kolahdouzan, Mahshad Eriksson, Olle Moslem, Mohsen Bergström, Joakim Ingelsson, Martin O’Callaghan, Paul Healy, Luke M. Falk, Anna
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Published in
Journal of Neuroinflammation
BackgroundAlzheimer’s disease (AD) and Parkinson’s disease (PD) are characterized by brain accumulation of aggregated amyloid-beta (Aβ) and alpha-synuclein (αSYN), respectively. In order to develop effective therapies, it is crucial to understand how the Aβ/αSYN aggregates can be cleared. Compelling data indicate that neuroinflammatory cells, inclu...
Pappalardo, Xena Giada Barra, Viviana
Published in
Epigenetics & Chromatin
BackgroundDNA methylation is an epigenetic chromatin mark that allows heterochromatin formation and gene silencing. It has a fundamental role in preserving genome stability (including chromosome stability) by controlling both gene expression and chromatin structure. Therefore, the onset of an incorrect pattern of DNA methylation is potentially dang...
Lin, Yangyang Jin, Jian Lv, Rongke Luo, Yuan Dai, Weiping Li, Wenchang Tang, Yamei Wang, Yuling Ye, Xiaojing Lin, Wei-Jye
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Published in
Acta Neuropathologica Communications
Alzheimer’s disease (AD) is a progressive neurodegenerative disease with high prevalence rate among the elderly population. A large number of clinical studies have suggested repetitive transcranial magnetic stimulation (rTMS) as a promising non-invasive treatment for patients with mild to moderate AD. However, the underlying cellular and molecular ...
Joubert, Sven Gardy, Ludovic Didic, Mira Rouleau, Isabelle Barbeau, Emmanuel J
Published in
Neuropsychology review
Accumulating evidence over the past decade suggests that semantic deficits represent a consistent feature of Mild Cognitive Impairment (MCI). A meta-analysis was performed to examine if semantic deficits are consistently found in patients with MCI. Studies meeting all inclusion criteria were selected for the current meta-analysis. An effect size an...
