Zhu, Gaofeng Bai, Ping Wang, Keren Mi, Jing Yang, Jing Hu, Jiaqi Ban, Yujuan Xu, Ran Chen, Rui Wang, Changning
...
Published in
Journal of enzyme inhibition and medicinal chemistry
Herein, a series of novel O-alkyl ferulamide derivatives were designed and synthesised through the multi-target-directed ligands (MTDLs) strategy. The biological activities in vitro showed that compounds 5a, 5d, 5e, 5f, and 5h indicated significantly selective MAO-B inhibitory potency (IC50 = 0.32, 0.56, 0.54, 0.73, and 0.86 μM, respectively) and m...
Wang, Zhibin Yang, Jianwei Zhu, Wei Tang, Yi Jia, Jianping
Published in
The International journal of neuroscience
Objective: Synaptic degeneration is the pathologic foundation of cognitive decline in the Alzheimer's disease (AD) continuum. We aimed to determine whether cerebrospinal fluid (CSF) synaptic marker neurogranin (Ng) is a disease state or a disease stage biomarker in the AD continuum.Methods: Studies comparing CSF Ng levels among AD, mild cognitive i...
Shippy, Daniel C Ulland, Tyler K
Published in
IBRO neuroscience reports
Alzheimer's disease (AD) is a progressive neurological disorder, and increasing evidence suggests AD pathology is driven by metabolic dysfunction in the brain. Zinc is the second most abundant trace element found in the human body and is required by all living organisms. Zinc is used extensively in many biological processes, and alterations in zinc...
Trujillo-Estrada, Laura Sanchez-Mejias, Elisabeth Sanchez-Varo, Raquel Garcia-Leon, Juan Antonio Nuñez-Diaz, Cristina Davila, Jose Carlos Vitorica, Javier LaFerla, Frank M Moreno-Gonzalez, Ines Gutierrez, Antonia
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Published in
The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry
Alzheimer's disease (AD) is an incurable neurodegenerative disease affecting over 45 million people worldwide. Transgenic mouse models have made remarkable contributions toward clarifying the pathophysiological mechanisms behind the clinical manifestations of AD. However, the limited ability of these in vivo models to accurately replicate the biolo...
Hickman, Susan E Mitchell, Susan L Hanson, Laura C Tu, Wanzhu Stump, Timothy E Unroe, Kathleen T
Published in
Clinical trials (London, England)
A significant number of people with Alzheimer's disease or related dementia diagnoses will be cared for in nursing homes near the end of life. Advance care planning (ACP), the process of eliciting and documenting patient-centered preferences for care, is considered essential to providing high quality care for this population. Nursing homes are curr...
Pike, Kerryn E Cavuoto, Marina G Li, Lily Wright, Bradley J Kinsella, Glynda J
Published in
Neuropsychology review
Subjective Cognitive Decline (SCD) in older adults has been identified as a risk factor for dementia, although the literature is inconsistent, and it is unclear which factors moderate progression from SCD to dementia. Through separate meta-analyses, we aimed to determine if SCD increased the risk of developing dementia or mild cognitive impairment ...
Ibrahim, Weam W Kamel, Ahmed S Wahid, Ahmed Abdelkader, Noha F
Published in
Inflammopharmacology
Autophagy and mitochondrial deficits are characteristics of early phase of Alzheimer's disease (AD). Sodium-glucose cotransporter-2 inhibitors have been nominated as a promising class against AD hallmarks. However, there are no available data yet to discuss the impact of gliflozins on autophagic pathways in AD. Peripherally, dapagliflozin's (DAPA) ...
Khalifa, Mona Abdelsalam, Rania M Safar, Marwa M Zaki, Hala F
Published in
Inflammopharmacology
The most prevalent type of dementia is Alzheimer's disease (AD), which is currently incurable. Existing treatments for Alzheimer's disease, such as acetylcholinesterase inhibitors, are only effective for symptom relief. Disease-modifying medications for Alzheimer's disease are desperately required, given the enormous burdens that the disease places...
Song, Xinping Zhao, Zijian Zhao, Yujuan Wang, Zhiguo Wang, Chao Yang, Ge Li, Shengyu
Published in
Nutritional neuroscience
Probiotic intervention has beneficial effects on host brain function and behavior via regulating microbiota-gut-brain axis; however, the underlying mechanism is not yet understood. Herein, we investigated that the effects of Lactobacillus plantarum DP189 (DP189) administration in preventing cognitive dysfunction and pathology of Alzheimer's disease...
Maglione, Andréa V do Nascimento, Bruna P P Ribeiro, Miriam O de Souza, Talytha J L da Silva, Renata E C Sato, Monica A Penatti, Carlos A A Britto, Luiz R G de Souza, Janaina S Maciel, Rui M B
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Published in
Metabolic brain disease
Alzheimer disease's (AD) is a neurodegenerative disorder characterized by cognitive and behavioral impairment. The central nervous system is an important target of thyroid hormones (TH). An inverse association between serum triiodothyronine (T3) levels and the risk of AD symptoms and progression has been reported. We investigated the effects of T3 ...
