Alzheimer’s disease (AD) is the most common form of dementia. Neuroimaging data is an integral part of the clinical assessment providing a way for clinicians to detect brain abnormalities for AD diagnosis. Anatomical MRI has been widely used to assess structural brain atrophy for AD detection and prediction. In addition to structural changes, metab...
Published in Dementia (London, England)
Published in Acta neurologica Belgica
There are many conflicting beliefs about Alzheimer's disease in the general population. Conducting a study on public awareness, attitude, and knowledge towards Alzheimer's disease is useful in decreasing discrimination and stigmatization. This study aims to determine the public perception and attitude towards Alzheimer's disease in Jeddah, Saudi Ar...
Published in Dementia (London, England)
MRI-visible perivascular spaces (PVS) in the semioval centre are associated with cerebral amyloid angiopathy (CAA), but it is unknown if PVS co-localize with MRI markers of CAA. To examine this, we assessed the topographical association between cortical cerebral microbleeds (CMBs) - as an indirect marker of CAA - and dilatation of juxtacortical per...
Published in The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry
Traumatic brain injury (TBI) is a major health problem in the United States, which affects about 1.7 million people each year. Glial cells, T-cells, and mast cells perform specific protective functions in different regions of the brain for the recovery of cognitive and motor functions after central nervous system (CNS) injuries including TBI. Chron...
Published in Dementia (London, England)
Published in International journal of pharmaceutics
Alzheimer's disease (AD) is a common and severe brain disease with a high mortality among the elders, but no highly efficient medications are currently available. For example, timosaponin BII, an efficient anti-AD agent, has low oral bioavailability. Here, timosaponin BII was formulated in a temperature/ion-sensitive in situ hydrogel (ISG) that was...
Neurodegenerative diseases, including Alzheimer&rsquo / s disease (AD), Parkinson&rsquo / s disease (PD) and amyotrophic lateral sclerosis (ALS), increase as the population ages around the world. Environmental factors also play an important role in most cases. Alcohol consumption exists extensively and it acts as one of the environmental factors th...
Published in Alzheimer's Research & Therapy
BackgroundPathological analysis of brain tissue from animals and humans with a history of traumatic brain injury (TBI) suggests that TBI could be one of the risk factors facilitating onset of dementia with possible Alzheimer’s disease (AD), but medications to prevent or delay AD onset are not yet available.MethodsThis study explores four medication...
