Zhou, Da-An Xu, Kai Zhao, Xiaobin Chen, Qian Sang, Feng Fan, Di Su, Li Zhang, Zhanjun Ai, Lin Chen, Yaojing
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Published in
Frontiers in Aging Neuroscience
Increased amyloid burden and decreased glucose metabolism are important characteristics of Alzheimer’s disease (AD), but their spatial distribution and hierarchical clustering organization are still poorly understood. In this study, we explored the distribution and clustering organization of amyloid and glucose metabolism based on 18F-florbetapir a...
Lee, Brian Yao, Xiaohui Shen, Li
Published in
BMC Genomics
Background Although genome-wide association studies (GWAS) have successfully located various genetic variants susceptible to Alzheimer’s Disease (AD), it is still unclear how specific variants interact with genes and tissues to elucidate pathologies associated with AD. Summary-data-based Mendelian Randomization (SMR) addresses this problem through ...
Xue, Bin Waseem, Shah Mohammad Abbas Zhu, Zhixin Alshahrani, Mohammed A. Nazam, Nazia Anjum, Farah Habib, Alaa Hamed Rafeeq, Misbahuddin M. Nazam, Fauzia Sharma, Monika
...
Published in
Frontiers in Neuroscience
Brain-derived neurotrophic factor (BDNF) involving tropomyosin kinase B and low affinity p75 neurotropin receptors is the most abundant and researched neurotropins in mammal’s brain. It is one of the potential targets for therapeutics in Alzheimer’s disease (AD) owing to its key role in synaptic plasticity. Low levels of BDNF are implicated in the ...
Yoshida, Shun Hasegawa, Takafumi
Published in
Frontiers in Aging Neuroscience
Retromer is a highly integrated multimeric protein complex that mediates retrograde cargo sorting from endosomal compartments. In concert with its accessory proteins, the retromer drives packaged cargoes to tubular and vesicular structures, thereby transferring them to the trans-Golgi network or to the plasma membrane. In addition to the endosomal ...
Liu, Junxiu Jiao, Linchi Zhong, Xin Yao, Weifan Du, Ke Lu, Senxu Wu, Yuqiang Ma, Tianxin Tong, Junhui Xu, Mingyue
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Published in
Frontiers in Aging Neuroscience
PTAFR exacerbates the neuronal inflammatory microenvironment in AD brain.
Amft, Michaela Ortner, Marion Eichenlaub, Udo Goldhardt, Oliver Diehl-Schmid, Janine Hedderich, Dennis M. Yakushev, Igor Grimmer, Timo
Published in
Alzheimer's Research & Therapy
Background Cerebrospinal fluid (CSF) analysis for detecting amyloid positivity may be as reliable as positron emission tomography (PET). We evaluated the performance of the amyloid beta (Aβ)42/40 ratio for predicting amyloid positivity by PET, compared with Aβ42 alone, and phosphorylated tau 181 (pTau181)/Aβ42 and total tau (tTau)/Aβ42 ratios, usin...
iqbal;, md danish
Neurodegenerative disorders involve various pathophysiological pathways, and finding a solution for these issues is still an uphill task for the scientific community. In the present study, a combination of molecular docking and dynamics approaches was applied to target different pathways leading to neurodegenerative disorders such as Alzheimer’s di...
Liu, Yingxu Zhang, Ye Thyreau, Benjamin Tatewaki, Yasuko Matsudaira, Izumi Takano, Yuji Hirabayashi, Naoki Furuta, YoshihikTo Jun, Hata Ninomiya, Toshiharu
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Published in
The journals of gerontology. Series A, Biological sciences and medical sciences
Altruistic social activity, such as giving support to others, has shown protective benefits on dementia risk and cognitive decline. However, the pathological mechanism is unclear. In the present study, we investigated the association between altruistic social activity and brain regional gray matter. Furthermore, to explore the psychological interpl...
Giacomucci, Giulia Galdo, Giulia Polito, Cristina Berti, Valentina Padiglioni, Sonia Mazzeo, Salvatore Chiaro, Eleonora De Cristofaro, Maria Teresa Bagnoli, Silvia Nacmias, Benedetta
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Published in
Behavioural brain research
Empathy is the ability to understand (cognitive empathy) and to feel (affective empathy) what others feel. The aim of the study was to assess empathy deficit and neuronal correlates in Subjective Cognitive Decline (SCD), Mild Cognitive Impairment (MCI) and Alzheimer's Disease (AD) dementia. Twenty-four SCD, 41 MCI and 46 CE patients were included. ...
chaves, on of on of giovanna
Nuclear DNA has been the main source of genome-wide loci association in neurodegenerative diseases, only partially accounting for the heritability of Alzheimer’s Disease (AD). In this context, mitochondrial DNA (mtDNA) is gaining more attention. Here, we investigated mitochondrial genes and genetic variants that may influence mild cognitive impairm...
