Mahan, Brandon Hu, Yan Lahoud, Esther Nestmeyer, Mark McCoy-West, Alex Manestar, Grace Fowler, Christopher Bush, Ashley I Moynier, Frédéric
Published in
Metallomics : integrated biometal science
The Alzheimer's disease (AD) affected brain purges K with concurrently increasing serum K, suggesting brain-blood K transferal. Here, natural stable K isotope ratios-δ41K-of human serum samples were characterized in an AD biomarker pilot study (plus two paired Li-heparin and K-EDTA plasma samples). AD serum was found to have a significantly lower m...
Liu, Rex Durbin-Johnson, Blythe Paciotti, Brian Liu, Albert T Weakley, Alyssa Liu, Xin Wan, Yu-Jui Yvonne
IntroductionThe incidence of Alzheimer's disease (AD) and obesity rise concomitantly. This study examined whether factors affecting metabolism, race/ethnicity, and sex are associated with AD development.MethodsThe analyses included patients ≥ 65 years with AD diagnosis in six University of California hospitals between January 2012 and October 2023....
Forbes, Melanie
Human interactions with the environment today add pressure on the world’s resources and ecosystems, which in turn harm human health. Many anthropogenic environmental changes, including climate change, biodiversity loss, and pollution, have accelerated morbidity and mortality. Research across multiple countries have found correlations between anthro...
Rubinsztein, David Nixon, Ralph
Autophagy is a lysosome-based degradative process used to recycle obsolete cellular constituents and eliminate damaged organelles and aggregate-prone proteins. Their post-mitotic nature and extremely polarized morphologies make neurons particularly vulnerable to disruptions caused by autophagy– lysosomal defects, especially as the brain ages. Conse...
Schartz, Nicole D Liang, Heidi Y Carvalho, Klebea Chu, Shu-Hui Mendoza-Arvilla, Adrian Petrisko, Tiffany J Gomez-Arboledas, Angela Mortazavi, Ali Tenner, Andrea J
Alzheimer's disease (AD) is the leading cause of dementia in older adults, and the need for effective, sustainable therapeutic targets is imperative. The complement pathway has been proposed as a therapeutic target. C5aR1 inhibition reduces plaque load, gliosis, and memory deficits in animal models, however, the cellular bases underlying this neuro...
Tosun, Duygu Hausle, Zachary Iwaki, Hirotaka Thropp, Pamela Lamoureux, Jennifer Lee, Edward B MacLeod, Karen McEvoy, Sean Nalls, Michael Perrin, Richard J
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IntroductionAlzheimer's disease (AD) pathology is defined by β-amyloid (Aβ) plaques and neurofibrillary tau, but Lewy bodies (LBs; ?-synuclein aggregates) are a common co-pathology for which effective biomarkers are needed.MethodsA validated α-synuclein Seed Amplification Assay (SAA) was used on recent cerebrospinal fluid (CSF) samples from 1638 Al...
Ghatak, Swagata Diedrich, Jolene K Talantova, Maria Bhadra, Nivedita Scott, Henry Sharma, Meetal Albertolle, Matthew Schork, Nicholas J Yates, John R Lipton, Stuart A
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Standard single-cell (sc) proteomics of disease states inferred from multicellular organs or organoids cannot currently be related to single-cell physiology. Here, a scPatch-Clamp/Proteomics platform is developed on single neurons generated from hiPSCs bearing an Alzheimer's disease (AD) genetic mutation and compares them to isogenic wild-type cont...
Rambachan, Aksharananda Neilands, Torsten B Karliner, Leah Covinsky, Kenneth Fang, Margaret Nguyen, Tung
BackgroundPain is ubiquitous, yet understudied. The objective of this study was to analyze inequities in pain assessment and management for hospitalized older adults focusing on demographic and geriatric-related variables.MethodsThis was a retrospective cohort study from January 2013 through September 2021 of all adults 65 years or older on the gen...
Ajroudi, Khaoula Jemai, Olfa
Language impairment is a key biomarker for neurodegenerative diseases such as Alzheimer's disease (AD). With the rapid growth of Large Language Models, natural language processing (NLP) has become a preferred modality for the early prediction of AD from speech. In this work, we propose a two-stage process for early detection of AD from transcriptio...
Valdivieso-Mora, Esmeralda Salazar-Villanea, Monica Johnson, David K
This study evaluated the measurement invariance of a neuropsychological battery across rural and urban older adults from Costa Rica. Rural and urban older adults (N = 295) from the Epidemiology and Development of Alzheimer's Disease (EDAD) study in Costa Rica were assessed. The baseline factor model for the EDAD neuropsychological measures was iden...
