peer reviewed / During immune reconstitution following allogeneic haematopoietic stem cell transplantation (allo-HSCT), (re)vaccination of allo-HSCT recipients is recommended. Herein, we propose an update of practical recommendations regarding vaccination of allo-HSCT recipients. These recommendations, based on data from the literature, national an...
La greffe de cellules souches hématopoïétiques (CSH) allogéniques demeure le seul traitement curatif de certaines hémopathies myéloïdes. L’effet antitumoral est véhiculé par les lymphocytes T (LT) du donneur qui ciblent les cellules cancéreuses du receveur. Malheureusement, les études prospectives et rétrospectives à long-terme rapportent un taux d...
L’allogreffe de cellules hématopoïétiques (allo-CH) est un traitement curatif de nombreuses hémopathies malignes et non malignes. La prévention de la rechute hématologique, des infections post-transplantation et de la maladie du greffon contre l'hôte (GvHD) est un défi majeur après allo-CH. Par conséquent, le développement de stratégies thérapeutiq...
Published in Bulletin du cancer
Inherited Metabolic Diseases (IMD) are rare genetic diseases, including both lysosomal and peroxisomal diseases. Lysosomal diseases are related to the deficiency of one or more lysosomal enzymes or transporter. Lysosomal diseases are progressive and involve several tissues with most often neurological damage. Among peroxisomal diseases, X-linked ad...
Published in Bulletin du cancer
Since patients require multiple intravenous drugs, drug incompatibilities and drug interactions are frequent during the acute phase following hematopoietic cell transplantation. The risk of drug-drug interactions is increased in patients with several comorbidities. The goal of this workshop was to learn how to mitigate the risks of drug incompatibi...
Published in Bulletin du cancer
Hemorrhagic cystitis (HC) is a common complication after allogeneic hematopoietic cell transplantation (allo-HCT). Its manifestations range from microscopic hematuria without urinary symptoms to extensive and prolonged macroscopic hemorrhage requiring invasive interventions that can often prolong the duration of hospitalization and result in signif...
Published in Bulletin du cancer
Autologous and allogeneic hematopoietic stem cell transplantation (HSCT) can lead to early cardiac complications as well as late sequelae. A cardiac evaluation is essential in the pre-transplant assessment given the patient's comorbidities and previous chemotherapy treatments received. Various thresholds of cardiac function are recommended as eligi...
Published in Bulletin du cancer
The COVID-19 pandemic disorganized the allogeneic stem cell transplantation activities all over the world, with the necessity to cryopreserve allografts to secure the procedure for both the recipient and the donor. Cryopreservation, usually anecdotal, has been used by all the French speaking centers; data collected from 24 centers were assessed in ...
Bien que l’allogreffe de cellules souches hématopoïétiques (ACSH) puisse sauver des vies, il est désormais bien établi que la qualité de vie (QDV) des patients est fortement impactée par cette procédure. L'association du statut socio-économique avec la qualité de vie liée à la santé (QVLS) n'a pas été décrite précédemment. Nous avons évalué ici l'i...
Introduction: les lymphomes B à grandes cellules (LBGC) sont des sous-types agressifs mais curables de lymphomes non hodgkiniens (LNH). Les patients atteints de LBGC en rechutes ou réfractaires (R/R) ont un pronostic très sombre avec une survie globale médiane d'environ 6 mois. Jusqu'à récemment, la transplantation de cellules souches hématopoïétiq...
