Graff, Patrick Woerz, Dana Wilzopolski, Jenny Voss, Anne Sarrazin, Jana Blimkie, Travis M Weiner, January Kershaw, Olivia Panwar, Preety Hackett, Tillie
...
Published in
The Journal of investigative dermatology
The development of atopic dermatitis in infancy, and subsequent allergies, such as asthma in later childhood, is known as the atopic march. The mechanism is largely unknown, however the course of disease indicates an inter-epithelial crosstalk, through the onset of inflammation in the skin and progression to other mucosal epithelia. In this study, ...
Huang, Jianan Cai, Hui Ye, Xiaofen Zhang, Ge Ye, Ling Yang, Chunxin Wang, Jian Jin, Meiling
Published in
International Archives of Allergy and Immunology
Introduction: Demethylzeylasteral (T-96), a new extract of Tripterygium wilfordii Hook F, exerted immunomodulatory properties in autoimmune diseases, but its effect on airway inflammatory diseases remains unclear. Our study aims to explore the protective effect and underlying mechanism of T-96 in allergic asthma. Methods: The OVA-induced asthmatic ...
Martín-Cruz, Leticia Benito-Villalvilla, Cristina Sirvent, Sofía Angelina, Alba Palomares, Oscar
Published in
International Archives of Allergy and Immunology
Background: Allergy represents a major health problem of increasing prevalence worldwide with a high socioeconomic impact. Our knowledge on the molecular mechanisms underlying allergic diseases and their treatments has significantly improved over the last years. The generation of allergen-specific regulatory T cells (Tregs) is crucial in the induct...
Matos Semedo, Filipa Martins, Catarina Tomaz, Elza Cardoso, Bárbara Farinha, Sofia Martins, Marta Paula Pires, Ana Inácio, Filipe Taborda-Barata, Luís
Published in
International Archives of Allergy and Immunology
Background: Dust mites are the leading cause of respiratory allergic diseases worldwide. Allergy to storage mites (SMs) has mostly been related to occupational exposures. However, recent studies have shown that sensitisation to SM, such as Lepidoglyphus destructor (Lep d), is of considerable importance also in urban populations, with high prevalenc...
Mohammed, Zainab Khaleel Smail, Shukur Wasman Janson, Christer Amin, Kawa
Given asthma’s large phenotypic diversity, the study was aimed to use specific biomarkers to characterize Allergic asthma (AA) and its severity. Blood was collected from 42 healthy controls (HCs) and 96 patients with AA. Biomarkers related to blood cell number and function: total leukocyte count (TLCs), neutrophil, lymphocyte, monocyte, eosinophil,...
Yao, Shifei Weng, Danlin Wang, Yan Zhang, Yanyu Huang, Qi Wu, Kaifeng Li, Honghui Zhang, Xuemei Yin, Yibing Xu, Wenchun
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Published in
Journal of translational medicine
Early microbial exposure is associate with protective allergic asthma. We have previously demonstrated that Streptococcus pneumoniae aminopeptidase N (PepN), one of the pneumococcal components, inhibits ovalbumin (OVA) -induced airway inflammation in murine models of allergic asthma, but the underlying mechanism was incompletely determined. BALB/c ...
Bernstein, Jonathan A Llanos, Jean-Pierre Hunter, Gillian Martin, Neil Ambrose, Christopher S
Published in
Advances in therapy
Patients with uncontrolled, allergic severe asthma may be prescribed biologic therapies to reduce exacerbations and improve disease control. Randomized controlled trials (RCTs) of these therapies have differed in design, with varying results overall and by baseline blood eosinophil count (BEC). This study describes published annualized asthma exace...
Lei, Fan Wu, Yang Li, Chongyao Yan, Biao Chen, Shaohui Peng, Qi Yang, Xu Ma, Ping
Published in
Journal of hazardous materials
Epidemiological evidence indicates a significant relationship between exposure to diisononyl phthalate and allergic asthma. Despite this, the mechanism underlying this association remains unclear. Previous toxicological researches have suggested that the development of allergic asthma may involve the activation of endoplasmic reticulum stress (ERS)...
Ike, Erina Kawano, Tasuku Takahashi, Kento Miyasaka, Tomomitsu Takahashi, Tomoko
Published in
International immunopharmacology
Allergic asthma is caused by chronic inflammation and hyper-responsiveness of the airway and is thought to be mediated by adaptive T helper type 2 (Th2)-driven immunity. However, recent studies have demonstrated that neuropeptide calcitonin gene-related peptide (CGRP)-mediated activation of group 2 innate lymphoid cells (ILC2s) may contribute to th...
Wafriy, Che Ismail Kamsani, Yuhaniza Shafinie Nor-Ashikin, Mohamed Noor Khan
Published in
Cells & development
The incidence of allergic asthma has been increasing worldwide in recent decades. Also, an increasing number of women are suffering from poor pregnancy outcome. However, the causal relationship between allergic asthma and embryonic growth in terms of cell morphogenesis has not been well elucidated. Here, we investigated the impact of allergic asthm...
