Wai, Christine Y Y Leung, Nicki Y H Leung, Agnes S Y Fusayasu, Naoko Sato, Sakura Xu, Kary J Y Yau, Yat Sun Rosa Duque, Jaime S Kwan, Mike Y W Cheng, James W C H
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Published in
Allergology international : official journal of the Japanese Society of Allergology
The current diagnostics of fish allergy lack sufficient accuracy such that more reliable tests such as component-resolved diagnosis (CRD) are urgently needed. This study aimed at identifying fish allergens of salmon and grass carp and evaluating the sensitization pattern in fish allergic subjects from two distinct populations in Asia. One hundred a...
Ford, Grayson James
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Jiao, Ji-Wei Zhan, Xiu-Hui Wang, Juan-Juan He, Li-Xia Guo, Zhen-Chang Xu, Xiu-E Liao, Lian-Di Huang, Xin Wen, Bing Xu, Yi-Wei
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Published in
Redox Biology
Lysyl-oxidase like-2 (LOXL2) regulates extracellular matrix remodeling and promotes tumor invasion and metastasis. Altered metabolism is a core hallmark of cancer, however, it remains unclear whether and how LOXL2 contributes to tumor metabolism. Here, we found that LOXL2 and its catalytically inactive L2Δ13 splice variant boost glucose metabolism ...
Le Moigne, Théo Sarti, Edoardo Nourisson, Antonin Zaffagnini, Mirko Carbone, Alessandra Lemaire, Stéphane D Henri, Julien
Published in
Journal of structural biology
The Calvin-Benson cycle fixes carbon dioxide into organic triosephosphates through the collective action of eleven conserved enzymes. Regeneration of ribulose-1,5-bisphosphate, the substrate of Rubisco-mediated carboxylation, requires two lyase reactions catalyzed by fructose-1,6-bisphosphate aldolase (FBA). While cytoplasmic FBA has been extensive...
Singh, Sumit Kumar Sarma, Moinak Sen
Published in
World Journal of Clinical Pediatrics
Hereditary fructose intolerance (HFI) is a rare autosomal recessive inherited disorder that occurs due to the mutation of enzyme aldolase B located on chromosome 9q22.3. A fructose load leads to the rapid accumulation of fructose 1-phosphate and manifests with its downstream effects. Most commonly children are affected with gastrointestinal symptom...
Dijkema, D Emons, J A M Van de Ven, A A J M Oude Elberink, J N G
Published in
Clinical reviews in allergy & immunology
Fish allergy is one of the most common food allergies. The currently recommended treatment commonly consists of avoiding all fish species. Recent literature suggests that these recommendations are overprotective for the majority of fish-allergic patients. This review summarizes recent findings and provides practical information regarding management...
Rouvinen, Juha Andberg, Martina Pääkkönen, Johan Hakulinen, Nina Koivula, Anu
Published in
Applied Microbiology and Biotechnology
Abstract Deoxyribose-5-phosphate aldolases (DERAs, EC 4.1.2.4) are acetaldehyde-dependent, Class I aldolases catalyzing in nature a reversible aldol reaction between an acetaldehyde donor (C2 compound) and glyceraldehyde-3-phosphate acceptor (C3 compound, C3P) to generate deoxyribose-5-phosphate (C5 compound, DR5P). DERA enzymes have been found to ...
Hui, Maggie H Rhine, Kevin Tolan, Dean R
Published in
Cytoskeleton (Hoboken, N.J.)
The glycolytic enzyme fructose 1,6-(bis)phosphate aldolase (aldolase) is not only required for efficient utilization of glucose and fructose, but also for cytoskeletal functions like cytokinesis and cell motility. These differing roles are mediated by distinct and discrete binding interactions with aldolase's many binding partners, including actin ...
Brunsell, Richard
Small proteins are difficult to study at high resolution with single-particle cryo-electron microscopy (cryo-EM). In general, sample properties such as large size (> 80 kDa), symmetry and rigidity are key to utilize this technology. To facilitate structural studies of small proteins as well, using cryo-EM, this project aims to incorporate a photo-i...
Bakari, Catherine Jones, Sophie Subramaniam, Gireesh Mandara, Celine I. Chiduo, Mercy G. Rumisha, Susan Chacky, Frank Molteni, Fabrizio Mandike, Renata Mkude, Sigsbert
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Published in
Malaria Journal
BackgroundHistidine-rich protein 2 (HRP2)-based malaria rapid diagnostic tests (RDTs) are effective and widely used for the detection of wild-type Plasmodium falciparum infections. Although recent studies have reported false negative HRP2 RDT results due to pfhrp2 and pfhrp3 gene deletions in different countries, there is a paucity of data on the d...
