Chen, Ke Yu, Bo Liao, Jie
Published in
Molecular Medicine
BackgroundAccumulating evidences have demonstrated that long non-coding RNAs (lncRNAs) are involved in the pathophysiology of diabetic nephropathy (DN). lncRNA SOX2OT plays an essential role in many diseases, including diabetes. Herein, we aim to investigate the underlying mechanism of lncRNA SOX2OT in DN pathogenesis.MethodsStreptozotocin-induced ...
Chen, Chiheng Zheng, Hanxiong
Published in
Frontiers in Molecular Biosciences
Long non-coding RNA (lncRNA) is a kind of RNA that possesses longer than 200 nucleotides and lacks protein coding function. It was recognized as a junk sequence for a long time. Recent studies have found that lncRNAs are actively functioning in almost every aspect of cell biology and involved in a variety of biological functions. LncRNAs are closel...
Querfurth, Henry Lee, Han-Kyu
Published in
Molecular Neurodegeneration
Novel targets to arrest neurodegeneration in several dementing conditions involving misfolded protein accumulations may be found in the diverse signaling pathways of the Mammalian/mechanistic target of rapamycin (mTOR). As a nutrient sensor, mTOR has important homeostatic functions to regulate energy metabolism and support neuronal growth and plast...
Zheng, Yu Zeng, Jin-Tao Wang, Xiang-Yu Huang, Hai-Xiao Huang, Liang-Xiang Zeng, Chang-Qing
Published in
Experimental and Therapeutic Medicine
Advanced oxidation protein products (AOPPs) are uremic toxins. The present study aimed to investigate the effects of AOPPs on the epithelial mesenchymal transition (EMT) and apoptosis of rat crypt epithelial cells, and to assess the signaling pathways involved. The oxidized rat serum albumin was obtained by sodium hypochlorite modification as AOPPs...
Wang, Nisha Ma, Jipeng Ma, Yan Lu, Linhe Ma, Chao Qin, Pei Gao, Erhe Zuo, Mingzhang Yang, Jian Yang, Lifang
...
Published in
Frontiers in Cardiovascular Medicine
Myocardial ischemia/reperfusion injury is a common clinical problem and can result in severe cardiac dysfunction. Previous studies have demonstrated the protection of electroacupuncture against myocardial ischemia/reperfusion injury. However, the role of X-box binding protein I (XBP1) signaling pathway in the protection of electroacupuncture was st...
Zha, Jian-hua Xia, Ying-chen Ye, Chun-lin Hu, Zhi Zhang, Qin Xiao, Han Yu, Ben-tong Xu, Wei-hua Xu, Guo-qiu
Published in
Frontiers in Oncology
In non-small-cell lung carcinoma (NSCLC), aberrant activation of mammalian target of rapamycin (mTOR) contributes to tumorigenesis and cancer progression. PQR620 is a novel and highly-potent mTOR kinase inhibitor. We here tested its potential activity in NSCLC cells. In primary human NSCLC cells and established cell lines (A549 and NCI-H1944), PQR6...
Tan, Lei Tang, Yiming Li, Hongbo Li, Pengju Ye, Yunlin Cen, Junjie Gui, Chengpeng Luo, Junhang Cao, Jiazheng Wei, Jinhuan
...
Published in
Frontiers in Oncology
Most localized human renal clear cell carcinoma (ccRCC)-related deaths result from cancer recurrence and metastasis. However, the precise molecular mechanisms largely remain unknown. In recent years, an increasing number of long noncoding RNAs (lncRNAs) have been shown to be vital regulators of tumorigenesis. In this study, we characterized a lncRN...
McKay, Lauren K White, James P
Published in
Cells
Once believed to solely function as a cyclin-dependent kinase inhibitor, p27Kip1 is now emerging as a critical mediator of autophagy, cytoskeletal dynamics, cell migration and apoptosis. During periods of metabolic stress, the subcellular location of p27Kip1 largely dictates its function. Cytoplasmic p27Kip1 has been found to be promote cellular re...
Rozier, Romain Paul, Rachel Madji Hounoum, Blandine Villa, Elodie Mhaidly, Rana Chiche, Johanna Verhoeyen, Els Marchetti, Sandrine Vandenberghe, Ashaina Raucoules, Marc
...
Published in
The FEBS journal
Myocardial ischemia/reperfusion (I/R) injury is a frequent perioperative threat, with numerous strategies developed to limit and/or prevent it. One interesting axis of research is the anesthetic preconditioning (APc) agent's hypothesis (such as sevoflurane, SEV). However, APc's mode of action is still poorly understood and volatile anesthetics used...
Wang, Yi Liao, Hongjuan Wang, Yueheng Zhou, Jinlin Wang, Feng Xie, Yingxin Zhao, Kun Gao, Weinian
Published in
BMC Cardiovascular Disorders
BackgroundCardiovascular diseases have become the leading cause of death worldwide, and cardiac hypertrophy is the core mechanism underlying cardiac defect and heart failure. However, the underlying mechanisms of cardiac hypertrophy are not fully understood. Here we investigated the roles of Kallikrein 11 (KLK11) in cardiac hypertrophy.MethodsHuman...
