Xiao, Dongliang Zhou, Quan Gao, Yunbing Cao, Baichuan Zhang, Qiong Zeng, Gaofeng Zong, Shaohui
Published in
Journal of cellular biochemistry
Perturbations in the balanced process of osteoblast-mediated bone formation and osteoclast-mediated bone resorption leading to excessive osteoclast formation and/or activity is the cause of many pathological bone conditions such as osteoporosis. The osteoclast is the only cell in the body capable of resorbing and degrading the mineralized bone matr...
Fu, Fang Li, Lu-Shan Li, Ru Deng, Qiong Yu, Qiu-Xia Yang, Xin Pan, Min Han, Jin Zhen, Li Zhang, Li-Na
...
Published in
Journal of cellular biochemistry
The pluripotent mouse embryonal carcinoma cell line P19 is widely used as a model for research on all-trans-retinoid acid (RA)-induced neuronal differentiation; however, the signaling pathways involved in this process remain unclear. This study aimed to reveal the molecular mechanism underlying the RA-induced neuronal differentiation of P19 cells. ...
Ahuja, Akash Kim, Eunji Sung, Gi-Ho Cho, Jae Youl
Published in
International Journal of Molecular Sciences
Toll-like receptor 4 (TLR4) signaling is an important therapeutic target to manage lipopolysaccharide (LPS)-induced inflammation. The transcription factor signal transducer and activator of transcription 3 (STAT3) has been identified as an important regulator of various immune-related diseases and has generated interest as a therapeutic target. Her...
Huang, Shile
Published in
Cells
The mechanistic/mammalian target of rapamycin (mTOR), a serine/threonine kinase, is a central regulator for human physiological activity. Deregulated mTOR signaling is implicated in a variety of disorders, such as cancer, obesity, diabetes, and neurodegenerative diseases. The papers published in this special issue summarize the current understandin...
Tsirtsaki, Katerina Gkretsi, Vasiliki
Published in
Cell Adhesion & Migration
Cell-extracellular matrix interactions, or focal adhesions (FA), are crucial for tissue homeostasis but are also implicated in cancer. Integrin-Linked Kinase (ILK) is an abundantly expressed FA protein involved in multiple signaling pathways. Here, we reviewed the current literature on the role of ILK in breast cancer (BC). Articles included in vit...
Ramadan, Fadi H. J. Szabo, Aliz Kovacs, Dominika Takatsy, Aniko Bognar, Rita Gallyas, Ferenc Jr. Bognar, Zita
Published in
International Journal of Molecular Sciences
Previously, we showed that desethylamiodarone (DEA), a major metabolite of the widely used antiarrhythmic drug amiodarone, has direct mitochondrial effects. We hypothesized that these effects account for its observed cytotoxic properties and ability to limit in vivo metastasis. Accordingly, we examined DEA’s rapid (3–12 h) cytotoxicity and its earl...
Wang, Mei Chang, Shan-Quan Tian, Yu-Shan Zhang, Ge-Qiang Qi, Jin
Published in
Rejuvenation research
The incidence of type 2 diabetes mellitus (T2DM) has been increasing in recent years and has become a serious threat to human health. Zengye Decoction (ZYD), a well-known traditional Chinese medicinal formula, has been used in the treatment of T2DM with yin asthenia and extreme heat since Qing Dynasty. However, the characteristics of antidiabetic a...
Nishio, Eiji Hayashi, Takanori Akaza, Mao Hisatomi, Yukiko Hikichi, Masahiro Fujii, Takuma Utsumi, Toshiaki Harada, Nobuhiro Shimono, Yohei
Published in
FEBS open bio
Everolimus (EVE), an inhibitor of mammalian target of rapamycin, is an emerging second-line therapeutic option for hormone therapy-resistant breast cancers. However, some patients do not respond to EVE, whereas in others it exacerbates the disease. Cellular inhibitor of protein phosphatase 2A (CIP2A) is a human oncoprotein that can promote cancer c...
Ishibashi, Kenichi Takeda, Yoshihiro Nakata, Lisa Hakuno, Fumihiko Takahashi, Shin-Ichiro Atsumi, Gen-Ichi
Published in
Biochimie
The dietary intake of elaidate (elaidic acid), a trans-fatty acid, is associated with the development of various diseases. Since elaidate is a C18 unsaturated fatty acid with a steric structure similar to that of a C18 saturated fatty acid (stearate), we previously revealed that insulin-dependent glucose uptake was impaired in adipocytes exposed to...
An, Xin Lin, Xi Yang, Anli Jiang, Qiwei Geng, Bingchuan Huang, Mayan Lu, Jiabin Xiang, Zhicheng Yuan, Zhongyu Wang, Shusen
...
Published in
Frontiers in Pharmacology
Objective Cavin3 is a putative tumor suppressor protein. However, its molecular action on tumor regulation is largely unknown. The aim of the current study is to explore the implication of cavin3 alteration, its clinical significance, and any potential molecular mechanisms in the regulation of breast cancer (BC). Methods TCGA (The Cancer Genome Atl...
