Sui, Xinbing Han, Xuemeng Chen, Peng Wu, Qibiao Feng, Jiao Duan, Ting Chen, Xiaying Pan, Ting Yan, Lili Jin, Ting
...
Published in
Frontiers in Molecular Biosciences
Baicalin, as a natural active ingredient extracted and isolated from the traditional Chinese medicine Scutellaria baicalensis Georgi., has been potentially used in various areas for its antioxidative, antitumor, anti-inflammatory, and anti-proliferative activities. Although several studies have reported the antitumor effects of baicalin against var...
Theodossiou, Sophia K. Murray, Jett B. Hold, LeeAnn A. Courtright, Jeff M. Carper, Anne M. Schiele, Nathan R.
Published in
Stem Cell Research & Therapy
BackgroundTissue engineered and regenerative approaches for treating tendon injuries are challenged by the limited information on the cellular signaling pathways driving tenogenic differentiation of stem cells. Members of the transforming growth factor (TGF) β family, particularly TGFβ2, play a role in tenogenesis, which may proceed via Smad-mediat...
Song, Guanjun Huang, Yun Xiong, Mingrui Yang, Ziwei Liu, Qinghua Shen, Jinhua Zhao, Ping Yang, Xinzhou
Published in
Frontiers in Pharmacology
Aloperine (ALO), a quinolizidine alkaloid isolated from Sophora alopecuroides L. used in the traditional Uygur medicine, induced a significant increase in cellular glucose uptake of L6 cells, suggesting it has the potential to relieve hyperglycemia. Therefore, we investigated the effects of ALO on type 2 diabetes mellitus (T2DM) through in vitro an...
Tokinoya, Katsuyuki Sekine, Nanami Aoki, Kai Ono, Seiko Kuji, Tomoaki Sugasawa, Takehito Yoshida, Yasuko Takekoshi, Kazuhiro
Published in
Molecular Medicine Reports
Progression of nonalcoholic steatohepatitis (NASH) is attributed to several factors, including inflammation and oxidative stress. In recent years, renalase has been reported to suppress oxidative stress, apoptosis and inflammation. A number of studies have suggested that renalase may be associated with protecting the liver from injury. The present ...
Monti, Noemi Masiello, Maria Grazia Proietti, Sara Catizone, Angela Ricci, Giulia Harrath, Abdel Halim Alwasel, Saleh H. Cucina, Alessandra Bizzarri, Mariano
Published in
International Journal of Molecular Sciences
Metazoan living cells exposed to microgravity undergo dramatic changes in morphological and biological properties, which ultimately lead to apoptosis and phenotype reprogramming. However, apoptosis can occur at very different rates depending on the experimental model, and in some cases, cells seem to be paradoxically protected from programmed cell ...
Zhao, Helen Lin, Jonathan Sieck, Gary Haddad, Gabriel G.
Published in
Frontiers in Neuroscience
Chronic mountain sickness (CMS) is a disease that potentially threatens a large segment of high-altitude populations during extended living at altitudes above 2,500 m. Patients with CMS suffer from severe hypoxemia, excessive erythrocytosis and neurologic deficits. The cellular mechanisms underlying CMS neuropathology remain unknown. We previously ...
Wu, Jinjun Kong, Muyan Lou, Yanmei Li, Leyan Yang, Chunlin Xu, Huifang Cui, Yuqi Hao, Hong Liu, Zhenguo
Published in
Frontiers in Pharmacology
Formononetin (FMNT) is a major bioactive compound from Astragalus membranaceus (Fisch.) Bunge, and has been widely used to treat conditions related to vascular insufficiency. However, the molecular mechanism for the therapeutic effect has not been well defined. This study aimed to investigate the effect and mechanism of FMNT on endothelial function...
Chan, Stefanie Smith, Emma Gao, Yuan Kwan, Julian Blum, Benjamin C Tilston-Lunel, Andrew M Turcinovic, Isabella Varelas, Xaralabos Cardamone, Maria Dafne Monti, Stefano
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Published in
Frontiers in cell and developmental biology
G Protein Suppressor 2 (GPS2) is a multifunctional protein that exerts important roles in inflammation and metabolism in adipose, liver, and immune cells. GPS2 has recently been identified as a significantly mutated gene in breast cancer and other malignancies and proposed to work as a putative tumor suppressor. However, molecular mechanisms by whi...
Lawrence, Marcus M Zwetsloot, Kevin A Arthur, Susan T Sherman, Chase A Huot, Joshua R Badmaev, Vladimir Grace, Mary Lila, Mary Ann Nieman, David C Shanely, R Andrew
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Published in
International journal of environmental research and public health
Skeletal muscle mass and strength are lost with aging. Phytoecdysteroids, in particular 20-hydroxyecdysone (20E), increase protein synthesis in C2C12 skeletal muscle cells and muscle strength in young rats. The objective of this study was to determine whether an extract from Ajuga turkestanica (ATE), enriched in phytoecdysteroids, and 20E affect sk...
Guo, Zhi-Feng Kong, Fan-Long
Published in
Oncology Letters
Histone H2AX (H2A.X) is a variant of the histone H2A family. Phosphorylation of H2A.X is a marker of DNA strand breaks and the presence or absence of H2A.X is closely related to tumor susceptibility and drug resistance. The present study found that the activity of the serine/threonine kinase Akt was negatively associated with H2A.X phosphorylated a...
