He, Wenxin Cao, Xiankun Kong, Keyu Rong, Kewei Han, Shuai Qin, An
Published in
Frontiers in Endocrinology
Background Ceritinib is used for the treatment of patients with anaplastic lymphoma kinase (ALK)-rearranged non-small cell lung cancer (NSCLC), who are at the risk of developing bone metastasis. During bone metastasis, tumor cells release factors that induce osteoclast formation, resulting in osteolysis. However, the effect of ceritinib on osteocla...
Mancini, Andrea Colapietro, Alessandro Cristiano, Loredana Rossetti, Alessandra Mattei, Vincenzo Gravina, Giovanni Luca Perez-Montoyo, Héctor Yeste-Velasco, Marc Alfon, Jose Domenech, Carles
...
Published in
Frontiers in Oncology
Background Glioblastoma multiforme (GBM) is the most malignant adult brain tumor. Current standard of care treatments have very limited efficacy, being the patients´ overall survival 14 months and the 2-year survival rate less than 10%. Therefore, the treatment of GBM is an urgent unmet clinical need. Methods The aim of this study was to investigat...
Kajitani, Naoko Schwartz, Stefan
Published in
Seminars in cancer biology
Human papillomaviruses (HPV) are epitheliotropic DNA tumor viruses that are prevalent in the human population. A subset of the HPVs termed high-risk HPVs (HR-HPVs) are causative agents of anogenital cancers and head-and-neck cancers. Cancer is the result of persistent high-risk HPV infections that have not been cleared by the immune system of the h...
Zhou, Ping Deng, Feng Yang, Zi Cao, Canhui Zhao, Hongcui Liu, Fenting Zhong, Ke Fu, Lin Peng, Tianliu Sun, Di
...
Published in
Science China. Life sciences
Ginsenoside Rb1 shows a strong antioxidant effect and has potential activation effects on Akt. The aim of the present study was to investigate the protective effect of Rb1 on age-related ovarian granulosa cell injury. Ovarian granulosa cells (GCs) were obtained from 50 young women (≤30 years) and 50 aged women (≥38 years) at an IVF center. Young an...
Liu, Yanfei Tian, Shifeng Yi, Ben Feng, Zhiqiang Chu, Tianhao Liu, Jun Zhang, Chunze Zhang, Shiwu Wang, Yijia
Published in
Frontiers in Oncology
Cetuximab is a monoclonal antibody against epidermal growth factor receptor that blocks downstream signaling pathways of receptor tyrosine kinases, including Ras/Raf/MAPK and PI3K/Akt, thereby inhibiting tumor cell proliferation and inducing cancer cell apoptosis. Owing to KRAS mutations, the effectiveness of cetuximab is usually limited by intrins...
Kim, Jieun Kim, Su-Jin Jeong, Ha-Ram Park, Jin-Hee Moon, Minho Hoe, Hyang-Sook
Published in
Frontiers in Immunology
The FDA-approved EGFR/HER2 inhibitor varlitinib inhibits tumor growth and is used in cancer treatment. However, the neuroinflammatory response associated with EGFR/HER2 and its underlying mechanism have not been elucidated. This study evaluates the impact of varlitinib on LPS- and tau-mediated neuroinflammatory responses for the first time. In BV2 ...
Liu, Longteng Zhang, Jinsong Han, Yanxi Liu, Dongge
Published in
Frontiers in Endocrinology
Soundararajan, Ramani Hernández-Cuervo, Helena Stearns, Timothy M Griswold, Anthony J Patil, Sahebgowda Sidramagowda Fukumoto, Jutaro Narala, Venkata Ramireddy Galam, Lakshmi Lockey, Richard Kolliputi, Narasaiah
...
Published in
Frontiers in Pharmacology
Background: Critically ill patients on supplemental oxygen therapy eventually develop acute lung injury (ALI). Reactive oxygen species (ROS) produced during ALI perturbs the mitochondrial dynamics resulting in cellular damage. Genetic deletion of the mitochondrial A-kinase anchoring protein 1 (Akap1) in mice resulted in mitochondrial damage, Endopl...
Birnbaum, Yochai Chen, Huan Tran, Dat Nylander, Sven Ye, Yumei
Published in
Cardiovascular drugs and therapy
Ticagrelor and dapagliflozin can suppress the activation of the NOD-like receptor 3 (NLRP3)-inflammasome and activate AMP-activated protein kinase (AMPK). The anti-inflammatory effects of dapagliflozin has been shown to depend on AMPK activation. Dapagliflozin and ticagrelor have been shown to have additive effects on the progression of diabetic ca...
Ren, Xiaoyan Yu, Jiangang Guo, Lili Zhang, Zaili
Published in
Metabolic brain disease
CDGSH iron sulfur domain 2 (Cisd2) is known as a key determinant factor in maintaining cellular homeostasis. However, whether Cisd2 contributes to the mediation of neuronal injury during ischemic stroke has not been well stressed. This work focuses on investigating the role of Cisd2 in regulating neuronal injury caused by oxygen-glucose deprivation...
